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Gene: PPP5C |
Gene summary for PPP5C |
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Gene information | Species | Human | Gene symbol | PPP5C | Gene ID | 5536 |
Gene name | protein phosphatase 5 catalytic subunit | |
Gene Alias | PP5 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024R0Q7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5536 | PPP5C | LZE2T | Human | Esophagus | ESCC | 6.38e-04 | 5.18e-01 | 0.082 |
5536 | PPP5C | LZE4T | Human | Esophagus | ESCC | 2.24e-07 | 2.83e-01 | 0.0811 |
5536 | PPP5C | LZE7T | Human | Esophagus | ESCC | 4.41e-07 | 4.77e-01 | 0.0667 |
5536 | PPP5C | LZE8T | Human | Esophagus | ESCC | 2.57e-07 | 2.94e-01 | 0.067 |
5536 | PPP5C | LZE22D1 | Human | Esophagus | HGIN | 1.39e-05 | 1.94e-01 | 0.0595 |
5536 | PPP5C | LZE22T | Human | Esophagus | ESCC | 1.18e-02 | 3.19e-01 | 0.068 |
5536 | PPP5C | LZE24T | Human | Esophagus | ESCC | 4.29e-12 | 3.05e-01 | 0.0596 |
5536 | PPP5C | LZE6T | Human | Esophagus | ESCC | 4.28e-08 | 4.47e-01 | 0.0845 |
5536 | PPP5C | P1T-E | Human | Esophagus | ESCC | 2.29e-14 | 4.04e-01 | 0.0875 |
5536 | PPP5C | P2T-E | Human | Esophagus | ESCC | 1.19e-26 | 4.91e-01 | 0.1177 |
5536 | PPP5C | P4T-E | Human | Esophagus | ESCC | 2.01e-22 | 5.76e-01 | 0.1323 |
5536 | PPP5C | P5T-E | Human | Esophagus | ESCC | 2.48e-21 | 4.99e-01 | 0.1327 |
5536 | PPP5C | P8T-E | Human | Esophagus | ESCC | 5.24e-57 | 1.08e+00 | 0.0889 |
5536 | PPP5C | P9T-E | Human | Esophagus | ESCC | 4.08e-14 | 3.01e-01 | 0.1131 |
5536 | PPP5C | P10T-E | Human | Esophagus | ESCC | 2.87e-38 | 7.80e-01 | 0.116 |
5536 | PPP5C | P11T-E | Human | Esophagus | ESCC | 4.52e-16 | 6.19e-01 | 0.1426 |
5536 | PPP5C | P12T-E | Human | Esophagus | ESCC | 2.62e-35 | 6.43e-01 | 0.1122 |
5536 | PPP5C | P15T-E | Human | Esophagus | ESCC | 2.33e-37 | 7.94e-01 | 0.1149 |
5536 | PPP5C | P16T-E | Human | Esophagus | ESCC | 1.45e-24 | 4.30e-01 | 0.1153 |
5536 | PPP5C | P17T-E | Human | Esophagus | ESCC | 4.02e-16 | 6.60e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697927 | Esophagus | HGIN | response to oxidative stress | 107/2587 | 446/18723 | 3.91e-09 | 2.76e-07 | 107 |
GO:004312220 | Esophagus | HGIN | regulation of I-kappaB kinase/NF-kappaB signaling | 63/2587 | 249/18723 | 8.91e-07 | 3.61e-05 | 63 |
GO:000724918 | Esophagus | HGIN | I-kappaB kinase/NF-kappaB signaling | 67/2587 | 281/18723 | 3.84e-06 | 1.29e-04 | 67 |
GO:004312317 | Esophagus | HGIN | positive regulation of I-kappaB kinase/NF-kappaB signaling | 49/2587 | 186/18723 | 4.22e-06 | 1.40e-04 | 49 |
GO:007099727 | Esophagus | HGIN | neuron death | 81/2587 | 361/18723 | 5.01e-06 | 1.61e-04 | 81 |
GO:006219727 | Esophagus | HGIN | cellular response to chemical stress | 76/2587 | 337/18723 | 8.00e-06 | 2.41e-04 | 76 |
GO:003052220 | Esophagus | HGIN | intracellular receptor signaling pathway | 62/2587 | 265/18723 | 1.63e-05 | 4.50e-04 | 62 |
GO:003459926 | Esophagus | HGIN | cellular response to oxidative stress | 65/2587 | 288/18723 | 3.42e-05 | 8.66e-04 | 65 |
GO:004854527 | Esophagus | HGIN | response to steroid hormone | 73/2587 | 339/18723 | 6.06e-05 | 1.40e-03 | 73 |
GO:000030226 | Esophagus | HGIN | response to reactive oxygen species | 52/2587 | 222/18723 | 7.30e-05 | 1.66e-03 | 52 |
GO:004593626 | Esophagus | HGIN | negative regulation of phosphate metabolic process | 89/2587 | 441/18723 | 1.24e-04 | 2.54e-03 | 89 |
GO:001056326 | Esophagus | HGIN | negative regulation of phosphorus metabolic process | 89/2587 | 442/18723 | 1.34e-04 | 2.71e-03 | 89 |
GO:190121424 | Esophagus | HGIN | regulation of neuron death | 68/2587 | 319/18723 | 1.46e-04 | 2.91e-03 | 68 |
GO:00165708 | Esophagus | HGIN | histone modification | 92/2587 | 463/18723 | 1.70e-04 | 3.30e-03 | 92 |
GO:000647017 | Esophagus | HGIN | protein dephosphorylation | 61/2587 | 281/18723 | 1.86e-04 | 3.51e-03 | 61 |
GO:004232620 | Esophagus | HGIN | negative regulation of phosphorylation | 78/2587 | 385/18723 | 2.77e-04 | 4.77e-03 | 78 |
GO:004668618 | Esophagus | HGIN | response to cadmium ion | 20/2587 | 68/18723 | 6.35e-04 | 8.73e-03 | 20 |
GO:004254220 | Esophagus | HGIN | response to hydrogen peroxide | 35/2587 | 146/18723 | 6.58e-04 | 9.01e-03 | 35 |
GO:000193320 | Esophagus | HGIN | negative regulation of protein phosphorylation | 69/2587 | 342/18723 | 6.81e-04 | 9.26e-03 | 69 |
GO:003051818 | Esophagus | HGIN | intracellular steroid hormone receptor signaling pathway | 29/2587 | 116/18723 | 9.06e-04 | 1.15e-02 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0401014 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
hsa0401015 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP5C | SNV | Missense_Mutation | c.559A>G | p.Thr187Ala | p.T187A | P53041 | protein_coding | deleterious(0) | possibly_damaging(0.494) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PPP5C | SNV | Missense_Mutation | rs148346594 | c.1409G>A | p.Arg470Gln | p.R470Q | P53041 | protein_coding | tolerated(0.05) | benign(0) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PPP5C | SNV | Missense_Mutation | rs370743592 | c.301N>T | p.Arg101Cys | p.R101C | P53041 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP5C | SNV | Missense_Mutation | rs866767367 | c.211N>A | p.Ala71Thr | p.A71T | P53041 | protein_coding | deleterious(0.02) | benign(0.209) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP5C | SNV | Missense_Mutation | c.139G>A | p.Ala47Thr | p.A47T | P53041 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
PPP5C | SNV | Missense_Mutation | c.1111N>T | p.Arg371Trp | p.R371W | P53041 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PPP5C | SNV | Missense_Mutation | c.139N>A | p.Ala47Thr | p.A47T | P53041 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PPP5C | SNV | Missense_Mutation | novel | c.1462N>A | p.Ala488Thr | p.A488T | P53041 | protein_coding | deleterious(0) | benign(0.181) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP5C | SNV | Missense_Mutation | c.913G>A | p.Glu305Lys | p.E305K | P53041 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PPP5C | SNV | Missense_Mutation | rs758489583 | c.763N>A | p.Glu255Lys | p.E255K | P53041 | protein_coding | tolerated(0.4) | benign(0.013) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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