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Gene: POLR2F |
Gene summary for POLR2F |
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Gene information | Species | Human | Gene symbol | POLR2F | Gene ID | 5435 |
Gene name | RNA polymerase II, I and III subunit F | |
Gene Alias | HRBP14.4 | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B0QYL9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5435 | POLR2F | GSM4909281 | Human | Breast | IDC | 6.54e-25 | 6.48e-01 | 0.21 |
5435 | POLR2F | GSM4909282 | Human | Breast | IDC | 1.60e-04 | 3.38e-01 | -0.0288 |
5435 | POLR2F | GSM4909285 | Human | Breast | IDC | 2.20e-04 | 2.51e-01 | 0.21 |
5435 | POLR2F | GSM4909286 | Human | Breast | IDC | 2.68e-40 | 7.56e-01 | 0.1081 |
5435 | POLR2F | GSM4909290 | Human | Breast | IDC | 7.71e-08 | 3.52e-01 | 0.2096 |
5435 | POLR2F | GSM4909293 | Human | Breast | IDC | 2.02e-02 | -2.08e-01 | 0.1581 |
5435 | POLR2F | GSM4909294 | Human | Breast | IDC | 7.84e-04 | -1.22e-01 | 0.2022 |
5435 | POLR2F | GSM4909296 | Human | Breast | IDC | 1.62e-10 | -1.41e-01 | 0.1524 |
5435 | POLR2F | GSM4909297 | Human | Breast | IDC | 4.93e-15 | -4.04e-02 | 0.1517 |
5435 | POLR2F | GSM4909307 | Human | Breast | IDC | 3.03e-02 | 2.75e-01 | 0.1569 |
5435 | POLR2F | GSM4909308 | Human | Breast | IDC | 1.31e-05 | 2.64e-01 | 0.158 |
5435 | POLR2F | GSM4909309 | Human | Breast | IDC | 3.16e-05 | 2.05e-01 | 0.0483 |
5435 | POLR2F | GSM4909311 | Human | Breast | IDC | 1.98e-36 | -8.76e-02 | 0.1534 |
5435 | POLR2F | GSM4909312 | Human | Breast | IDC | 8.81e-17 | -2.11e-02 | 0.1552 |
5435 | POLR2F | GSM4909313 | Human | Breast | IDC | 3.69e-03 | 8.25e-03 | 0.0391 |
5435 | POLR2F | GSM4909319 | Human | Breast | IDC | 1.62e-44 | -2.36e-01 | 0.1563 |
5435 | POLR2F | GSM4909320 | Human | Breast | IDC | 2.17e-10 | 4.17e-02 | 0.1575 |
5435 | POLR2F | GSM4909321 | Human | Breast | IDC | 1.16e-16 | -5.08e-02 | 0.1559 |
5435 | POLR2F | brca2 | Human | Breast | Precancer | 4.93e-02 | 2.09e-01 | -0.024 |
5435 | POLR2F | M2 | Human | Breast | IDC | 3.54e-02 | -5.27e-02 | 0.21 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501623 | Breast | IDC | Huntington disease | 103/867 | 306/8465 | 5.14e-30 | 4.17e-28 | 3.12e-28 | 103 |
hsa0501633 | Breast | IDC | Huntington disease | 103/867 | 306/8465 | 5.14e-30 | 4.17e-28 | 3.12e-28 | 103 |
hsa0501643 | Breast | DCIS | Huntington disease | 101/846 | 306/8465 | 1.54e-29 | 1.24e-27 | 9.13e-28 | 101 |
hsa0501653 | Breast | DCIS | Huntington disease | 101/846 | 306/8465 | 1.54e-29 | 1.24e-27 | 9.13e-28 | 101 |
hsa0501620 | Endometrium | AEH | Huntington disease | 118/1197 | 306/8465 | 3.00e-27 | 2.44e-25 | 1.78e-25 | 118 |
hsa05016110 | Endometrium | AEH | Huntington disease | 118/1197 | 306/8465 | 3.00e-27 | 2.44e-25 | 1.78e-25 | 118 |
hsa0501625 | Endometrium | EEC | Huntington disease | 120/1237 | 306/8465 | 3.86e-27 | 4.23e-25 | 3.15e-25 | 120 |
hsa0501635 | Endometrium | EEC | Huntington disease | 120/1237 | 306/8465 | 3.86e-27 | 4.23e-25 | 3.15e-25 | 120 |
hsa0501630 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
hsa034205 | Esophagus | HGIN | Nucleotide excision repair | 29/1383 | 63/8465 | 2.96e-08 | 5.36e-07 | 4.26e-07 | 29 |
hsa030205 | Esophagus | HGIN | RNA polymerase | 12/1383 | 34/8465 | 5.62e-03 | 3.99e-02 | 3.17e-02 | 12 |
hsa05016113 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
hsa0342012 | Esophagus | HGIN | Nucleotide excision repair | 29/1383 | 63/8465 | 2.96e-08 | 5.36e-07 | 4.26e-07 | 29 |
hsa0302012 | Esophagus | HGIN | RNA polymerase | 12/1383 | 34/8465 | 5.62e-03 | 3.99e-02 | 3.17e-02 | 12 |
hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0342022 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0302021 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa046234 | Esophagus | ESCC | Cytosolic DNA-sensing pathway | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLR2F | SNV | Missense_Mutation | rs775564769 | c.122N>G | p.Ser41Cys | p.S41C | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.69) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
POLR2F | SNV | Missense_Mutation | novel | c.467N>A | p.Arg156Lys | p.R156K | protein_coding | unknown(0) | TCGA-CR-5248-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD | ||
POLR2F | SNV | Missense_Mutation | novel | c.43N>A | p.Asp15Asn | p.D15N | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.944) | TCGA-CV-A6JM-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
POLR2F | SNV | Missense_Mutation | rs550998177 | c.31N>A | p.Asp11Asn | p.D11N | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-BR-6455-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide phosphate | PD | |
POLR2F | SNV | Missense_Mutation | rs774791641 | c.34G>A | p.Asp12Asn | p.D12N | protein_coding | deleterious_low_confidence(0.03) | benign(0.007) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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