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Gene: PLTP |
Gene summary for PLTP |
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Gene information | Species | Human | Gene symbol | PLTP | Gene ID | 5360 |
Gene name | phospholipid transfer protein | |
Gene Alias | BPIFE | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P55058 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5360 | PLTP | AEH-subject1 | Human | Endometrium | AEH | 1.12e-04 | -2.87e-01 | -0.3059 |
5360 | PLTP | AEH-subject2 | Human | Endometrium | AEH | 2.37e-07 | -3.12e-01 | -0.2525 |
5360 | PLTP | AEH-subject3 | Human | Endometrium | AEH | 2.25e-02 | -1.07e-01 | -0.2576 |
5360 | PLTP | AEH-subject5 | Human | Endometrium | AEH | 1.49e-25 | -5.53e-01 | -0.2953 |
5360 | PLTP | EEC-subject1 | Human | Endometrium | EEC | 4.44e-06 | -3.23e-01 | -0.2682 |
5360 | PLTP | EEC-subject2 | Human | Endometrium | EEC | 5.86e-11 | -3.54e-01 | -0.2607 |
5360 | PLTP | EEC-subject3 | Human | Endometrium | EEC | 1.98e-35 | -5.38e-01 | -0.2525 |
5360 | PLTP | EEC-subject4 | Human | Endometrium | EEC | 7.13e-11 | -3.70e-01 | -0.2571 |
5360 | PLTP | EEC-subject5 | Human | Endometrium | EEC | 3.35e-19 | -4.74e-01 | -0.249 |
5360 | PLTP | GSM5276934 | Human | Endometrium | EEC | 2.94e-08 | -2.81e-01 | -0.0913 |
5360 | PLTP | GSM5276935 | Human | Endometrium | EEC | 4.32e-09 | -3.89e-01 | -0.123 |
5360 | PLTP | GSM5276937 | Human | Endometrium | EEC | 3.73e-02 | -2.74e-01 | -0.0897 |
5360 | PLTP | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.26e-20 | -6.53e-02 | -0.1869 |
5360 | PLTP | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.94e-15 | -2.67e-01 | -0.1875 |
5360 | PLTP | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.53e-19 | -2.27e-01 | -0.1883 |
5360 | PLTP | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.04e-18 | -7.04e-02 | -0.1934 |
5360 | PLTP | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 7.50e-27 | -3.38e-01 | -0.1917 |
5360 | PLTP | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 3.45e-33 | -2.31e-01 | -0.1916 |
5360 | PLTP | LZE4T | Human | Esophagus | ESCC | 5.00e-04 | -2.48e-01 | 0.0811 |
5360 | PLTP | LZE20T | Human | Esophagus | ESCC | 4.72e-07 | 7.77e-01 | 0.0662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00067661 | Esophagus | ESCC | vitamin metabolic process | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
GO:0009110 | Esophagus | ESCC | vitamin biosynthetic process | 15/8552 | 20/18723 | 7.60e-03 | 2.71e-02 | 15 |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:00108751 | Liver | Cirrhotic | positive regulation of cholesterol efflux | 15/4634 | 26/18723 | 3.43e-04 | 2.93e-03 | 15 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
GO:19016171 | Liver | Cirrhotic | organic hydroxy compound biosynthetic process | 81/4634 | 237/18723 | 6.73e-04 | 5.06e-03 | 81 |
GO:00323731 | Liver | Cirrhotic | positive regulation of sterol transport | 19/4634 | 38/18723 | 6.75e-04 | 5.06e-03 | 19 |
GO:00323761 | Liver | Cirrhotic | positive regulation of cholesterol transport | 19/4634 | 38/18723 | 6.75e-04 | 5.06e-03 | 19 |
GO:00343681 | Liver | Cirrhotic | protein-lipid complex remodeling | 16/4634 | 30/18723 | 7.20e-04 | 5.36e-03 | 16 |
GO:00343691 | Liver | Cirrhotic | plasma lipoprotein particle remodeling | 16/4634 | 30/18723 | 7.20e-04 | 5.36e-03 | 16 |
GO:00333441 | Liver | Cirrhotic | cholesterol efflux | 29/4634 | 69/18723 | 1.20e-03 | 8.12e-03 | 29 |
GO:001591811 | Liver | Cirrhotic | sterol transport | 48/4634 | 130/18723 | 1.32e-03 | 8.83e-03 | 48 |
GO:003030111 | Liver | Cirrhotic | cholesterol transport | 44/4634 | 117/18723 | 1.34e-03 | 8.98e-03 | 44 |
GO:00343671 | Liver | Cirrhotic | protein-containing complex remodeling | 16/4634 | 32/18723 | 1.77e-03 | 1.13e-02 | 16 |
GO:00718251 | Liver | Cirrhotic | protein-lipid complex subunit organization | 22/4634 | 50/18723 | 2.26e-03 | 1.37e-02 | 22 |
GO:00323711 | Liver | Cirrhotic | regulation of sterol transport | 31/4634 | 78/18723 | 2.43e-03 | 1.46e-02 | 31 |
GO:00323741 | Liver | Cirrhotic | regulation of cholesterol transport | 31/4634 | 78/18723 | 2.43e-03 | 1.46e-02 | 31 |
GO:19059521 | Liver | Cirrhotic | regulation of lipid localization | 62/4634 | 181/18723 | 2.53e-03 | 1.51e-02 | 62 |
GO:01200091 | Liver | Cirrhotic | intermembrane lipid transfer | 21/4634 | 48/18723 | 3.06e-03 | 1.73e-02 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049794 | Liver | HCC | Cholesterol metabolism | 41/4020 | 51/8465 | 1.33e-06 | 1.35e-05 | 7.49e-06 | 41 |
hsa033204 | Liver | HCC | PPAR signaling pathway | 48/4020 | 75/8465 | 2.83e-03 | 9.37e-03 | 5.21e-03 | 48 |
hsa049795 | Liver | HCC | Cholesterol metabolism | 41/4020 | 51/8465 | 1.33e-06 | 1.35e-05 | 7.49e-06 | 41 |
hsa033205 | Liver | HCC | PPAR signaling pathway | 48/4020 | 75/8465 | 2.83e-03 | 9.37e-03 | 5.21e-03 | 48 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLTP | insertion | Nonsense_Mutation | novel | c.1015_1016insTAGGATTACAGGCGTGAG | p.Pro339delinsLeuGlyLeuGlnAlaTerAla | p.P339delinsLGLQA*A | P55058 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
PLTP | SNV | Missense_Mutation | c.1360N>A | p.Gly454Arg | p.G454R | P55058 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AA-3660-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLTP | SNV | Missense_Mutation | rs373242157 | c.1048N>A | p.Val350Ile | p.V350I | P55058 | protein_coding | tolerated(0.11) | benign(0.229) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PLTP | SNV | Missense_Mutation | c.886N>A | p.Pro296Thr | p.P296T | P55058 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PLTP | SNV | Missense_Mutation | c.461A>G | p.His154Arg | p.H154R | P55058 | protein_coding | tolerated(0.6) | benign(0.012) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PLTP | SNV | Missense_Mutation | c.754G>A | p.Ala252Thr | p.A252T | P55058 | protein_coding | deleterious(0) | possibly_damaging(0.669) | TCGA-AA-A02K-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD | |
PLTP | SNV | Missense_Mutation | c.1288N>G | p.Thr430Ala | p.T430A | P55058 | protein_coding | tolerated(0.07) | benign(0.223) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PLTP | SNV | Missense_Mutation | c.763C>A | p.Pro255Thr | p.P255T | P55058 | protein_coding | deleterious(0.04) | probably_damaging(0.981) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
PLTP | SNV | Missense_Mutation | c.61N>T | p.Gly21Cys | p.G21C | P55058 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PLTP | SNV | Missense_Mutation | c.857N>G | p.Leu286Arg | p.L286R | P55058 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-G4-6625-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5360 | PLTP | DRUGGABLE GENOME | VITAMIN E | 15734742,15576481,12105225 | ||
5360 | PLTP | DRUGGABLE GENOME | ALPHA-TOCOPHEROL | VITAMIN E | 15576481,10224231 | |
5360 | PLTP | DRUGGABLE GENOME | SIMVASTATIN | SIMVASTATIN | 11566255 |
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