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Gene: PLSCR4 |
Gene summary for PLSCR4 |
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Gene information | Species | Human | Gene symbol | PLSCR4 | Gene ID | 57088 |
Gene name | phospholipid scramblase 4 | |
Gene Alias | TRA1 | |
Cytomap | 3q24 | |
Gene Type | protein-coding | GO ID | GO:0002237 | UniProtAcc | Q9NRQ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57088 | PLSCR4 | LZE8T | Human | Esophagus | ESCC | 1.59e-03 | -6.62e-03 | 0.067 |
57088 | PLSCR4 | P1T-E | Human | Esophagus | ESCC | 9.76e-05 | 1.33e-01 | 0.0875 |
57088 | PLSCR4 | P2T-E | Human | Esophagus | ESCC | 1.16e-24 | 3.66e-01 | 0.1177 |
57088 | PLSCR4 | P5T-E | Human | Esophagus | ESCC | 6.08e-03 | 4.40e-02 | 0.1327 |
57088 | PLSCR4 | P8T-E | Human | Esophagus | ESCC | 7.03e-16 | 2.64e-01 | 0.0889 |
57088 | PLSCR4 | P9T-E | Human | Esophagus | ESCC | 6.06e-08 | 1.34e-01 | 0.1131 |
57088 | PLSCR4 | P10T-E | Human | Esophagus | ESCC | 1.29e-11 | 1.17e-01 | 0.116 |
57088 | PLSCR4 | P11T-E | Human | Esophagus | ESCC | 3.17e-03 | 3.76e-01 | 0.1426 |
57088 | PLSCR4 | P12T-E | Human | Esophagus | ESCC | 3.04e-05 | 1.70e-02 | 0.1122 |
57088 | PLSCR4 | P15T-E | Human | Esophagus | ESCC | 2.20e-09 | 1.25e-02 | 0.1149 |
57088 | PLSCR4 | P16T-E | Human | Esophagus | ESCC | 7.35e-03 | -7.12e-02 | 0.1153 |
57088 | PLSCR4 | P20T-E | Human | Esophagus | ESCC | 1.05e-23 | 8.06e-01 | 0.1124 |
57088 | PLSCR4 | P21T-E | Human | Esophagus | ESCC | 2.44e-03 | -1.06e-01 | 0.1617 |
57088 | PLSCR4 | P22T-E | Human | Esophagus | ESCC | 1.01e-05 | -6.01e-02 | 0.1236 |
57088 | PLSCR4 | P23T-E | Human | Esophagus | ESCC | 6.70e-04 | 4.25e-01 | 0.108 |
57088 | PLSCR4 | P24T-E | Human | Esophagus | ESCC | 1.58e-08 | 4.21e-02 | 0.1287 |
57088 | PLSCR4 | P26T-E | Human | Esophagus | ESCC | 6.82e-06 | -9.15e-02 | 0.1276 |
57088 | PLSCR4 | P27T-E | Human | Esophagus | ESCC | 2.15e-14 | 3.85e-02 | 0.1055 |
57088 | PLSCR4 | P28T-E | Human | Esophagus | ESCC | 9.24e-06 | 1.61e-02 | 0.1149 |
57088 | PLSCR4 | P30T-E | Human | Esophagus | ESCC | 2.02e-07 | 3.21e-01 | 0.137 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003249619 | Esophagus | ESCC | response to lipopolysaccharide | 191/8552 | 343/18723 | 1.11e-04 | 7.73e-04 | 191 |
GO:000223719 | Esophagus | ESCC | response to molecule of bacterial origin | 194/8552 | 363/18723 | 1.64e-03 | 7.61e-03 | 194 |
GO:007122215 | Esophagus | ESCC | cellular response to lipopolysaccharide | 113/8552 | 209/18723 | 8.79e-03 | 3.10e-02 | 113 |
GO:007121617 | Esophagus | ESCC | cellular response to biotic stimulus | 131/8552 | 246/18723 | 9.85e-03 | 3.39e-02 | 131 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLSCR4 | SNV | Missense_Mutation | c.745N>T | p.Pro249Ser | p.P249S | Q9NRQ2 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-CM-4747-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | fluorouracil | SD | |
PLSCR4 | SNV | Missense_Mutation | c.430G>T | p.Asp144Tyr | p.D144Y | Q9NRQ2 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLSCR4 | SNV | Missense_Mutation | c.373C>A | p.Leu125Ile | p.L125I | Q9NRQ2 | protein_coding | tolerated(0.05) | benign(0.031) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLSCR4 | insertion | Frame_Shift_Ins | novel | c.427_428insCTGCATTGTC | p.Tyr143SerfsTer5 | p.Y143Sfs*5 | Q9NRQ2 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PLSCR4 | SNV | Missense_Mutation | rs139012801 | c.817N>A | p.Gly273Ser | p.G273S | Q9NRQ2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLSCR4 | SNV | Missense_Mutation | novel | c.572N>T | p.Arg191Ile | p.R191I | Q9NRQ2 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLSCR4 | SNV | Missense_Mutation | c.739N>A | p.Arg247Ser | p.R247S | Q9NRQ2 | protein_coding | tolerated(0.74) | benign(0.109) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PLSCR4 | SNV | Missense_Mutation | novel | c.508N>G | p.Thr170Ala | p.T170A | Q9NRQ2 | protein_coding | tolerated(0.48) | benign(0.038) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLSCR4 | SNV | Missense_Mutation | rs539660710 | c.472G>A | p.Glu158Lys | p.E158K | Q9NRQ2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLSCR4 | SNV | Missense_Mutation | rs745956616 | c.506N>A | p.Arg169Gln | p.R169Q | Q9NRQ2 | protein_coding | deleterious(0.02) | benign(0.375) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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