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Gene: PLAC8 |
Gene summary for PLAC8 |
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Gene information | Species | Human | Gene symbol | PLAC8 | Gene ID | 51316 |
Gene name | placenta associated 8 | |
Gene Alias | C15 | |
Cytomap | 4q21.22 | |
Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | Q9NZF1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51316 | PLAC8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.51e-22 | 1.75e+00 | -0.1808 |
51316 | PLAC8 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.07e-11 | 8.59e-01 | -0.1954 |
51316 | PLAC8 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.09e-06 | 2.49e+00 | -0.2602 |
51316 | PLAC8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.14e-09 | 1.83e+00 | -0.2196 |
51316 | PLAC8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.24e-04 | 6.39e-01 | -0.1207 |
51316 | PLAC8 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.15e-05 | 9.15e-01 | -0.1526 |
51316 | PLAC8 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.78e-11 | 1.10e+00 | -0.1464 |
51316 | PLAC8 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.77e-12 | 9.29e-01 | -0.059 |
51316 | PLAC8 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.67e-04 | 1.15e+00 | -0.1706 |
51316 | PLAC8 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.92e-12 | 1.76e+00 | -0.2061 |
51316 | PLAC8 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.47e-02 | -1.62e-01 | 0.294 |
51316 | PLAC8 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.70e-07 | -2.58e-01 | 0.3859 |
51316 | PLAC8 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.50e-09 | -2.89e-01 | 0.3005 |
51316 | PLAC8 | A002-C-010 | Human | Colorectum | FAP | 4.63e-05 | -2.24e-01 | 0.242 |
51316 | PLAC8 | A015-C-203 | Human | Colorectum | FAP | 5.29e-06 | -1.96e-01 | -0.1294 |
51316 | PLAC8 | A002-C-201 | Human | Colorectum | FAP | 3.49e-04 | -2.38e-01 | 0.0324 |
51316 | PLAC8 | A002-C-203 | Human | Colorectum | FAP | 1.58e-13 | -2.83e-01 | 0.2786 |
51316 | PLAC8 | A001-C-119 | Human | Colorectum | FAP | 1.06e-02 | -2.58e-01 | -0.1557 |
51316 | PLAC8 | A001-C-108 | Human | Colorectum | FAP | 3.40e-02 | -1.12e-01 | -0.0272 |
51316 | PLAC8 | A002-C-205 | Human | Colorectum | FAP | 6.04e-05 | -2.18e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009409 | Colorectum | AD | response to cold | 22/3918 | 49/18723 | 1.40e-04 | 1.98e-03 | 22 |
GO:0048638 | Colorectum | AD | regulation of developmental growth | 92/3918 | 330/18723 | 1.48e-03 | 1.25e-02 | 92 |
GO:0120162 | Colorectum | AD | positive regulation of cold-induced thermogenesis | 32/3918 | 97/18723 | 3.74e-03 | 2.63e-02 | 32 |
GO:0045926 | Colorectum | AD | negative regulation of growth | 70/3918 | 249/18723 | 4.07e-03 | 2.83e-02 | 70 |
GO:0106106 | Colorectum | AD | cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
GO:0120161 | Colorectum | AD | regulation of cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
GO:1990845 | Colorectum | AD | adaptive thermogenesis | 46/3918 | 157/18723 | 7.97e-03 | 4.73e-02 | 46 |
GO:00094091 | Colorectum | SER | response to cold | 16/2897 | 49/18723 | 2.11e-03 | 2.06e-02 | 16 |
GO:00459261 | Colorectum | SER | negative regulation of growth | 55/2897 | 249/18723 | 3.44e-03 | 2.92e-02 | 55 |
GO:0045444 | Colorectum | SER | fat cell differentiation | 51/2897 | 229/18723 | 3.96e-03 | 3.26e-02 | 51 |
GO:00094092 | Colorectum | MSS | response to cold | 19/3467 | 49/18723 | 7.20e-04 | 7.70e-03 | 19 |
GO:00486381 | Colorectum | MSS | regulation of developmental growth | 84/3467 | 330/18723 | 1.01e-03 | 1.01e-02 | 84 |
GO:0035264 | Colorectum | MSS | multicellular organism growth | 37/3467 | 132/18723 | 4.77e-03 | 3.34e-02 | 37 |
GO:00486382 | Colorectum | FAP | regulation of developmental growth | 75/2622 | 330/18723 | 1.11e-05 | 3.10e-04 | 75 |
GO:00352641 | Colorectum | FAP | multicellular organism growth | 31/2622 | 132/18723 | 2.28e-03 | 1.84e-02 | 31 |
GO:0001659 | Colorectum | FAP | temperature homeostasis | 38/2622 | 174/18723 | 3.16e-03 | 2.36e-02 | 38 |
GO:01061061 | Colorectum | FAP | cold-induced thermogenesis | 32/2622 | 144/18723 | 4.85e-03 | 3.25e-02 | 32 |
GO:01201611 | Colorectum | FAP | regulation of cold-induced thermogenesis | 32/2622 | 144/18723 | 4.85e-03 | 3.25e-02 | 32 |
GO:19908451 | Colorectum | FAP | adaptive thermogenesis | 34/2622 | 157/18723 | 5.77e-03 | 3.69e-02 | 34 |
GO:00094093 | Colorectum | FAP | response to cold | 14/2622 | 49/18723 | 5.95e-03 | 3.75e-02 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLAC8 | SNV | Missense_Mutation | novel | c.205N>A | p.Ala69Thr | p.A69T | Q9NZF1 | protein_coding | deleterious(0.04) | probably_damaging(0.99) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLAC8 | SNV | Missense_Mutation | novel | c.166N>T | p.Ala56Ser | p.A56S | Q9NZF1 | protein_coding | tolerated(1) | benign(0.005) | TCGA-EY-A1GF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLAC8 | SNV | Missense_Mutation | novel | c.83N>T | p.Thr28Ile | p.T28I | Q9NZF1 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLAC8 | SNV | Missense_Mutation | novel | c.85N>A | p.Gly29Ser | p.G29S | Q9NZF1 | protein_coding | tolerated(0.09) | benign(0.156) | TCGA-49-6767-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLAC8 | SNV | Missense_Mutation | c.145N>A | p.Cys49Ser | p.C49S | Q9NZF1 | protein_coding | deleterious(0.04) | probably_damaging(0.974) | TCGA-55-8203-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLAC8 | SNV | Missense_Mutation | c.77N>T | p.Trp26Leu | p.W26L | Q9NZF1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-22-5478-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PLAC8 | SNV | Missense_Mutation | novel | c.175N>G | p.Asn59Asp | p.N59D | Q9NZF1 | protein_coding | tolerated(0.62) | benign(0.007) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PLAC8 | SNV | Missense_Mutation | c.202N>A | p.Val68Ile | p.V68I | Q9NZF1 | protein_coding | tolerated(0.09) | possibly_damaging(0.739) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
PLAC8 | SNV | Missense_Mutation | c.316N>G | p.Ile106Val | p.I106V | Q9NZF1 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PLAC8 | deletion | Frame_Shift_Del | novel | c.242delC | p.Pro81LeufsTer38 | p.P81Lfs*38 | Q9NZF1 | protein_coding | TCGA-CG-4465-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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