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Gene: PI4KB |
Gene summary for PI4KB |
Gene summary. |
Gene information | Species | Human | Gene symbol | PI4KB | Gene ID | 5298 |
Gene name | phosphatidylinositol 4-kinase beta | |
Gene Alias | NPIK | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q9UBF8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5298 | PI4KB | LZE2T | Human | Esophagus | ESCC | 2.90e-02 | 3.99e-01 | 0.082 |
5298 | PI4KB | LZE4T | Human | Esophagus | ESCC | 7.43e-07 | 9.70e-02 | 0.0811 |
5298 | PI4KB | LZE7T | Human | Esophagus | ESCC | 8.68e-05 | 4.90e-01 | 0.0667 |
5298 | PI4KB | LZE8T | Human | Esophagus | ESCC | 1.01e-03 | 1.28e-01 | 0.067 |
5298 | PI4KB | LZE20T | Human | Esophagus | ESCC | 2.56e-06 | 1.24e-01 | 0.0662 |
5298 | PI4KB | LZE24T | Human | Esophagus | ESCC | 4.42e-12 | 3.63e-01 | 0.0596 |
5298 | PI4KB | P1T-E | Human | Esophagus | ESCC | 1.44e-09 | 4.98e-01 | 0.0875 |
5298 | PI4KB | P2T-E | Human | Esophagus | ESCC | 1.96e-36 | 4.83e-01 | 0.1177 |
5298 | PI4KB | P4T-E | Human | Esophagus | ESCC | 2.36e-12 | 1.51e-01 | 0.1323 |
5298 | PI4KB | P5T-E | Human | Esophagus | ESCC | 2.58e-14 | 1.72e-01 | 0.1327 |
5298 | PI4KB | P8T-E | Human | Esophagus | ESCC | 1.20e-22 | 2.65e-01 | 0.0889 |
5298 | PI4KB | P9T-E | Human | Esophagus | ESCC | 1.86e-09 | 3.31e-01 | 0.1131 |
5298 | PI4KB | P10T-E | Human | Esophagus | ESCC | 1.16e-16 | 3.93e-01 | 0.116 |
5298 | PI4KB | P11T-E | Human | Esophagus | ESCC | 1.49e-19 | 5.80e-01 | 0.1426 |
5298 | PI4KB | P12T-E | Human | Esophagus | ESCC | 2.94e-18 | 1.99e-01 | 0.1122 |
5298 | PI4KB | P15T-E | Human | Esophagus | ESCC | 3.89e-20 | 5.46e-01 | 0.1149 |
5298 | PI4KB | P16T-E | Human | Esophagus | ESCC | 1.28e-19 | 3.24e-01 | 0.1153 |
5298 | PI4KB | P17T-E | Human | Esophagus | ESCC | 1.43e-09 | 4.44e-01 | 0.1278 |
5298 | PI4KB | P19T-E | Human | Esophagus | ESCC | 4.38e-06 | 6.06e-01 | 0.1662 |
5298 | PI4KB | P20T-E | Human | Esophagus | ESCC | 5.45e-17 | 3.43e-01 | 0.1124 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:000689818 | Esophagus | ESCC | receptor-mediated endocytosis | 142/8552 | 244/18723 | 5.22e-05 | 4.05e-04 | 142 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:00066611 | Esophagus | ESCC | phosphatidylinositol biosynthetic process | 73/8552 | 131/18723 | 1.31e-02 | 4.28e-02 | 73 |
GO:00086542 | Liver | HCC | phospholipid biosynthetic process | 150/7958 | 253/18723 | 4.77e-08 | 1.03e-06 | 150 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
GO:004501711 | Liver | HCC | glycerolipid biosynthetic process | 143/7958 | 252/18723 | 3.27e-06 | 4.31e-05 | 143 |
GO:00066504 | Liver | HCC | glycerophospholipid metabolic process | 168/7958 | 306/18723 | 7.27e-06 | 8.62e-05 | 168 |
GO:004647411 | Liver | HCC | glycerophospholipid biosynthetic process | 121/7958 | 211/18723 | 9.12e-06 | 1.06e-04 | 121 |
GO:000689821 | Liver | HCC | receptor-mediated endocytosis | 134/7958 | 244/18723 | 5.73e-05 | 5.31e-04 | 134 |
GO:0006661 | Liver | HCC | phosphatidylinositol biosynthetic process | 69/7958 | 131/18723 | 1.19e-02 | 4.35e-02 | 69 |
GO:00086543 | Oral cavity | OSCC | phospholipid biosynthetic process | 130/7305 | 253/18723 | 3.96e-05 | 3.46e-04 | 130 |
GO:000689810 | Oral cavity | OSCC | receptor-mediated endocytosis | 125/7305 | 244/18723 | 6.56e-05 | 5.32e-04 | 125 |
GO:00464743 | Oral cavity | OSCC | glycerophospholipid biosynthetic process | 102/7305 | 211/18723 | 3.50e-03 | 1.48e-02 | 102 |
GO:00066445 | Oral cavity | OSCC | phospholipid metabolic process | 175/7305 | 383/18723 | 4.21e-03 | 1.71e-02 | 175 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PI4KB | SNV | Missense_Mutation | c.856N>T | p.Arg286Cys | p.R286C | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | ||
PI4KB | SNV | Missense_Mutation | rs372795296 | c.524G>A | p.Arg175Gln | p.R175Q | protein_coding | deleterious(0.01) | possibly_damaging(0.803) | TCGA-AZ-4682-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | camptosar | PD | |
PI4KB | SNV | Missense_Mutation | novel | c.1907N>C | p.Lys636Thr | p.K636T | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
PI4KB | SNV | Missense_Mutation | rs766903450 | c.644N>A | p.Arg215His | p.R215H | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PI4KB | deletion | Frame_Shift_Del | c.844delA | p.Arg282GlyfsTer14 | p.R282Gfs*14 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||||
PI4KB | deletion | Frame_Shift_Del | novel | c.480delN | p.Tyr161IlefsTer50 | p.Y161Ifs*50 | protein_coding | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |||
PI4KB | deletion | Frame_Shift_Del | c.117delN | p.Ser40ProfsTer3 | p.S40Pfs*3 | protein_coding | TCGA-AZ-6605-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfox | SD | ||||
PI4KB | SNV | Missense_Mutation | c.2428N>T | p.Arg810Trp | p.R810W | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
PI4KB | SNV | Missense_Mutation | novel | c.1944N>T | p.Gln648His | p.Q648H | protein_coding | tolerated(0.1) | benign(0.018) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PI4KB | SNV | Missense_Mutation | novel | c.1111N>A | p.Leu371Ile | p.L371I | protein_coding | tolerated(0.33) | benign(0.337) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5298 | PI4KB | KINASE, PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 178102683 | ||
5298 | PI4KB | KINASE, PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 252827496 | ||
5298 | PI4KB | KINASE, PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 178102681 | WORTMANNIN |
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