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Gene: PI15 |
Gene summary for PI15 |
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Gene information | Species | Human | Gene symbol | PI15 | Gene ID | 51050 |
Gene name | peptidase inhibitor 15 | |
Gene Alias | CRISP8 | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | O43692 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51050 | PI15 | GSM4909307 | Human | Breast | IDC | 3.61e-29 | 7.31e-01 | 0.1569 |
51050 | PI15 | GSM4909308 | Human | Breast | IDC | 1.34e-31 | 6.45e-01 | 0.158 |
51050 | PI15 | DCIS2 | Human | Breast | DCIS | 3.72e-03 | 5.40e-02 | 0.0085 |
51050 | PI15 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 6.16e-04 | 5.92e-01 | -0.23 |
51050 | PI15 | 052099_1652-all-cells | Human | Prostate | BPH | 4.97e-02 | 2.98e-01 | 0.1038 |
51050 | PI15 | Dong_P3 | Human | Prostate | Tumor | 1.39e-03 | 1.01e-01 | 0.0278 |
51050 | PI15 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 1.92e-05 | 8.78e-01 | 0.1557 |
51050 | PI15 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 3.40e-05 | 6.37e-01 | 0.1621 |
51050 | PI15 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 4.62e-08 | 9.04e-01 | 0.1608 |
51050 | PI15 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 2.10e-04 | 7.96e-01 | 0.1622 |
51050 | PI15 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 1.34e-03 | 4.26e-01 | 0.1575 |
51050 | PI15 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 1.34e-03 | 3.39e-01 | 0.1545 |
51050 | PI15 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.59e-03 | 4.21e-01 | 0.1569 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
GO:004586114 | Breast | IDC | negative regulation of proteolysis | 70/1434 | 351/18723 | 8.21e-14 | 2.22e-11 | 70 |
GO:005134613 | Breast | IDC | negative regulation of hydrolase activity | 71/1434 | 379/18723 | 1.33e-12 | 2.90e-10 | 71 |
GO:001046613 | Breast | IDC | negative regulation of peptidase activity | 56/1434 | 262/18723 | 1.39e-12 | 2.92e-10 | 56 |
GO:005254723 | Breast | DCIS | regulation of peptidase activity | 88/1390 | 461/18723 | 1.18e-16 | 4.78e-14 | 88 |
GO:004586123 | Breast | DCIS | negative regulation of proteolysis | 63/1390 | 351/18723 | 4.39e-11 | 6.06e-09 | 63 |
GO:005134623 | Breast | DCIS | negative regulation of hydrolase activity | 64/1390 | 379/18723 | 4.32e-10 | 4.80e-08 | 64 |
GO:001046622 | Breast | DCIS | negative regulation of peptidase activity | 49/1390 | 262/18723 | 1.54e-09 | 1.43e-07 | 49 |
GO:005254718 | Prostate | BPH | regulation of peptidase activity | 133/3107 | 461/18723 | 2.08e-11 | 1.43e-09 | 133 |
GO:004586118 | Prostate | BPH | negative regulation of proteolysis | 98/3107 | 351/18723 | 5.43e-08 | 1.49e-06 | 98 |
GO:005134616 | Prostate | BPH | negative regulation of hydrolase activity | 94/3107 | 379/18723 | 2.46e-05 | 2.94e-04 | 94 |
GO:001046616 | Prostate | BPH | negative regulation of peptidase activity | 68/3107 | 262/18723 | 7.28e-05 | 7.13e-04 | 68 |
GO:005254719 | Prostate | Tumor | regulation of peptidase activity | 137/3246 | 461/18723 | 2.48e-11 | 1.71e-09 | 137 |
GO:004586119 | Prostate | Tumor | negative regulation of proteolysis | 102/3246 | 351/18723 | 3.09e-08 | 9.94e-07 | 102 |
GO:005134617 | Prostate | Tumor | negative regulation of hydrolase activity | 97/3246 | 379/18723 | 2.87e-05 | 3.46e-04 | 97 |
GO:001046617 | Prostate | Tumor | negative regulation of peptidase activity | 70/3246 | 262/18723 | 8.76e-05 | 8.66e-04 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PI15 | SNV | Missense_Mutation | c.179N>A | p.Arg60His | p.R60H | O43692 | protein_coding | deleterious(0.01) | benign(0.363) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PI15 | SNV | Missense_Mutation | c.676N>T | p.Gly226Trp | p.G226W | O43692 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PI15 | SNV | Missense_Mutation | rs529529830 | c.67G>A | p.Val23Ile | p.V23I | O43692 | protein_coding | tolerated(0.21) | benign(0.042) | TCGA-DC-6158-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PI15 | SNV | Missense_Mutation | novel | c.232N>T | p.Arg78Trp | p.R78W | O43692 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PI15 | insertion | In_Frame_Ins | novel | c.760_761insCATTTTTTAAAAGTAGAT | p.Tyr253_Leu254insProPhePheLysSerArg | p.Y253_L254insPFFKSR | O43692 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PI15 | SNV | Missense_Mutation | novel | c.68N>A | p.Val23Asp | p.V23D | O43692 | protein_coding | deleterious(0.01) | benign(0.169) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PI15 | SNV | Missense_Mutation | novel | c.203T>A | p.Ile68Asn | p.I68N | O43692 | protein_coding | tolerated(0.48) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PI15 | SNV | Missense_Mutation | rs765167473 | c.398G>A | p.Arg133His | p.R133H | O43692 | protein_coding | tolerated(0.06) | probably_damaging(0.912) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PI15 | SNV | Missense_Mutation | novel | c.372T>G | p.Asn124Lys | p.N124K | O43692 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PI15 | SNV | Missense_Mutation | novel | c.125C>T | p.Ala42Val | p.A42V | O43692 | protein_coding | tolerated(0.29) | benign(0.036) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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