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Gene: PHYHD1 |
Gene summary for PHYHD1 |
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Gene information | Species | Human | Gene symbol | PHYHD1 | Gene ID | 254295 |
Gene name | phytanoyl-CoA dioxygenase domain containing 1 | |
Gene Alias | PHYHD1 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q5SRE7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
254295 | PHYHD1 | LZE24T | Human | Esophagus | ESCC | 3.44e-02 | -1.72e-01 | 0.0596 |
254295 | PHYHD1 | P2T-E | Human | Esophagus | ESCC | 5.51e-03 | -1.59e-01 | 0.1177 |
254295 | PHYHD1 | P4T-E | Human | Esophagus | ESCC | 1.67e-09 | 1.46e-01 | 0.1323 |
254295 | PHYHD1 | P5T-E | Human | Esophagus | ESCC | 2.50e-03 | -1.66e-01 | 0.1327 |
254295 | PHYHD1 | P8T-E | Human | Esophagus | ESCC | 4.66e-07 | -1.30e-01 | 0.0889 |
254295 | PHYHD1 | P9T-E | Human | Esophagus | ESCC | 4.09e-04 | -1.29e-01 | 0.1131 |
254295 | PHYHD1 | P10T-E | Human | Esophagus | ESCC | 1.69e-04 | -1.59e-01 | 0.116 |
254295 | PHYHD1 | P12T-E | Human | Esophagus | ESCC | 5.51e-10 | 2.93e-01 | 0.1122 |
254295 | PHYHD1 | P15T-E | Human | Esophagus | ESCC | 5.18e-03 | -1.37e-01 | 0.1149 |
254295 | PHYHD1 | P16T-E | Human | Esophagus | ESCC | 3.97e-04 | -1.84e-01 | 0.1153 |
254295 | PHYHD1 | P20T-E | Human | Esophagus | ESCC | 8.92e-17 | 5.07e-02 | 0.1124 |
254295 | PHYHD1 | P22T-E | Human | Esophagus | ESCC | 7.71e-04 | -1.56e-01 | 0.1236 |
254295 | PHYHD1 | P23T-E | Human | Esophagus | ESCC | 7.55e-03 | -1.47e-01 | 0.108 |
254295 | PHYHD1 | P24T-E | Human | Esophagus | ESCC | 6.24e-09 | 1.56e-01 | 0.1287 |
254295 | PHYHD1 | P26T-E | Human | Esophagus | ESCC | 2.05e-02 | -1.86e-01 | 0.1276 |
254295 | PHYHD1 | P27T-E | Human | Esophagus | ESCC | 2.55e-02 | 1.02e-01 | 0.1055 |
254295 | PHYHD1 | P31T-E | Human | Esophagus | ESCC | 5.13e-23 | 4.62e-01 | 0.1251 |
254295 | PHYHD1 | P32T-E | Human | Esophagus | ESCC | 4.10e-03 | -1.50e-01 | 0.1666 |
254295 | PHYHD1 | P37T-E | Human | Esophagus | ESCC | 3.15e-06 | -1.00e-01 | 0.1371 |
254295 | PHYHD1 | P38T-E | Human | Esophagus | ESCC | 1.18e-03 | 2.48e-01 | 0.127 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHYHD1 | SNV | Missense_Mutation | rs745410393 | c.863N>A | p.Arg288His | p.R288H | Q5SRE7 | protein_coding | tolerated_low_confidence(0.4) | benign(0) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
PHYHD1 | SNV | Missense_Mutation | novel | c.149N>A | p.Arg50His | p.R50H | Q5SRE7 | protein_coding | deleterious(0.05) | probably_damaging(0.939) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PHYHD1 | SNV | Missense_Mutation | novel | c.592N>T | p.Pro198Ser | p.P198S | Q5SRE7 | protein_coding | deleterious_low_confidence(0) | benign(0.058) | TCGA-AX-A3FS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHYHD1 | SNV | Missense_Mutation | rs745410393 | c.863N>A | p.Arg288His | p.R288H | Q5SRE7 | protein_coding | tolerated_low_confidence(0.4) | benign(0) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHYHD1 | SNV | Missense_Mutation | c.371N>T | p.Gln124Leu | p.Q124L | Q5SRE7 | protein_coding | deleterious(0.03) | benign(0.16) | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PHYHD1 | SNV | Missense_Mutation | novel | c.246N>T | p.Glu82Asp | p.E82D | Q5SRE7 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHYHD1 | SNV | Missense_Mutation | rs773749559 | c.746N>A | p.Arg249His | p.R249H | Q5SRE7 | protein_coding | tolerated_low_confidence(0.55) | benign(0) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHYHD1 | SNV | Missense_Mutation | novel | c.130N>A | p.Asp44Asn | p.D44N | Q5SRE7 | protein_coding | deleterious(0.04) | benign(0.164) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHYHD1 | SNV | Missense_Mutation | rs756034640 | c.253N>A | p.Val85Ile | p.V85I | Q5SRE7 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHYHD1 | SNV | Missense_Mutation | rs201809500 | c.131N>G | p.Asp44Gly | p.D44G | Q5SRE7 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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