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Gene: PFKP |
Gene summary for PFKP |
Gene summary. |
Gene information | Species | Human | Gene symbol | PFKP | Gene ID | 5214 |
Gene name | phosphofructokinase, platelet | |
Gene Alias | ATP-PFK | |
Cytomap | 10p15.2 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q01813 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5214 | PFKP | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.81e-04 | 4.21e-01 | -0.1808 |
5214 | PFKP | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.19e-05 | 3.93e-01 | -0.0811 |
5214 | PFKP | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.81e-03 | 6.94e-01 | -0.2196 |
5214 | PFKP | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.35e-03 | 3.23e-01 | -0.1207 |
5214 | PFKP | HTA11_696_2000001011 | Human | Colorectum | AD | 7.72e-03 | 3.05e-01 | -0.1464 |
5214 | PFKP | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.10e-07 | 4.42e-01 | -0.059 |
5214 | PFKP | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.22e-04 | 9.50e-01 | 0.3487 |
5214 | PFKP | A015-C-203 | Human | Colorectum | FAP | 1.62e-02 | -1.31e-01 | -0.1294 |
5214 | PFKP | A002-C-205 | Human | Colorectum | FAP | 5.90e-03 | -1.74e-01 | -0.1236 |
5214 | PFKP | A015-C-104 | Human | Colorectum | FAP | 4.16e-02 | -1.12e-01 | -0.1899 |
5214 | PFKP | A002-C-016 | Human | Colorectum | FAP | 4.86e-02 | -1.11e-01 | 0.0521 |
5214 | PFKP | A002-C-116 | Human | Colorectum | FAP | 1.05e-02 | -1.14e-01 | -0.0452 |
5214 | PFKP | AEH-subject1 | Human | Endometrium | AEH | 1.61e-08 | 4.27e-01 | -0.3059 |
5214 | PFKP | AEH-subject2 | Human | Endometrium | AEH | 5.96e-10 | 4.24e-01 | -0.2525 |
5214 | PFKP | AEH-subject4 | Human | Endometrium | AEH | 2.10e-03 | 2.84e-01 | -0.2657 |
5214 | PFKP | EEC-subject1 | Human | Endometrium | EEC | 1.94e-03 | 3.39e-01 | -0.2682 |
5214 | PFKP | EEC-subject2 | Human | Endometrium | EEC | 1.12e-13 | 5.96e-01 | -0.2607 |
5214 | PFKP | GSM5276937 | Human | Endometrium | EEC | 8.69e-09 | 3.45e-01 | -0.0897 |
5214 | PFKP | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.12e-11 | 5.32e-01 | -0.1869 |
5214 | PFKP | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.41e-08 | 4.56e-01 | -0.1875 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046034 | Colorectum | AD | ATP metabolic process | 142/3918 | 277/18723 | 2.64e-29 | 8.26e-26 | 142 |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0009135 | Colorectum | AD | purine nucleoside diphosphate metabolic process | 47/3918 | 103/18723 | 1.61e-08 | 9.22e-07 | 47 |
GO:0009179 | Colorectum | AD | purine ribonucleoside diphosphate metabolic process | 47/3918 | 103/18723 | 1.61e-08 | 9.22e-07 | 47 |
GO:0006090 | Colorectum | AD | pyruvate metabolic process | 47/3918 | 106/18723 | 4.85e-08 | 2.55e-06 | 47 |
GO:0009185 | Colorectum | AD | ribonucleoside diphosphate metabolic process | 47/3918 | 106/18723 | 4.85e-08 | 2.55e-06 | 47 |
GO:0046031 | Colorectum | AD | ADP metabolic process | 41/3918 | 90/18723 | 1.37e-07 | 6.42e-06 | 41 |
GO:0006096 | Colorectum | AD | glycolytic process | 38/3918 | 81/18723 | 1.52e-07 | 6.78e-06 | 38 |
GO:0006757 | Colorectum | AD | ATP generation from ADP | 38/3918 | 82/18723 | 2.26e-07 | 9.37e-06 | 38 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0009132 | Colorectum | AD | nucleoside diphosphate metabolic process | 49/3918 | 124/18723 | 1.75e-06 | 5.31e-05 | 49 |
GO:0046939 | Colorectum | AD | nucleotide phosphorylation | 42/3918 | 101/18723 | 1.99e-06 | 5.92e-05 | 42 |
GO:0016052 | Colorectum | AD | carbohydrate catabolic process | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa04919 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa05230 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa00051 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa01230 | Colorectum | AD | Biosynthesis of amino acids | 28/2092 | 75/8465 | 9.99e-03 | 3.89e-02 | 2.48e-02 | 28 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa040661 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa049191 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa052301 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa000511 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa012301 | Colorectum | AD | Biosynthesis of amino acids | 28/2092 | 75/8465 | 9.99e-03 | 3.89e-02 | 2.48e-02 | 28 |
hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa012002 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PFKP | deletion | Frame_Shift_Del | novel | c.1748delN | p.Met583ArgfsTer40 | p.M583Rfs*40 | Q01813 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
PFKP | deletion | Frame_Shift_Del | c.787delN | p.Arg265GlyfsTer2 | p.R265Gfs*2 | Q01813 | protein_coding | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |||
PFKP | SNV | Missense_Mutation | c.2195T>C | p.Val732Ala | p.V732A | Q01813 | protein_coding | deleterious(0.01) | possibly_damaging(0.635) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
PFKP | SNV | Missense_Mutation | rs200384787 | c.1109N>T | p.Ala370Val | p.A370V | Q01813 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PFKP | SNV | Missense_Mutation | c.1805N>T | p.Ala602Val | p.A602V | Q01813 | protein_coding | deleterious(0.02) | benign(0.163) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PFKP | SNV | Missense_Mutation | c.1241C>A | p.Ala414Asp | p.A414D | Q01813 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PFKP | SNV | Missense_Mutation | rs762200045 | c.1609N>A | p.Ala537Thr | p.A537T | Q01813 | protein_coding | deleterious(0) | benign(0.226) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PFKP | SNV | Missense_Mutation | c.1999A>T | p.Asn667Tyr | p.N667Y | Q01813 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PFKP | SNV | Missense_Mutation | rs760969268 | c.1690N>A | p.Asp564Asn | p.D564N | Q01813 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PFKP | SNV | Missense_Mutation | novel | c.247N>C | p.Ser83Pro | p.S83P | Q01813 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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