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Gene: PFKFB4 |
Gene summary for PFKFB4 |
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Gene information | Species | Human | Gene symbol | PFKFB4 | Gene ID | 5210 |
Gene name | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | |
Gene Alias | PFKFB4 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q16877 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5210 | PFKFB4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.94e-04 | 2.99e-01 | -0.0811 |
5210 | PFKFB4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.56e-03 | 2.71e-01 | -0.1464 |
5210 | PFKFB4 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.28e-03 | 2.92e-01 | -0.1001 |
5210 | PFKFB4 | LZE4T | Human | Esophagus | ESCC | 6.35e-03 | 1.33e-01 | 0.0811 |
5210 | PFKFB4 | P4T-E | Human | Esophagus | ESCC | 6.27e-06 | 1.54e-01 | 0.1323 |
5210 | PFKFB4 | P5T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.01e-01 | 0.1327 |
5210 | PFKFB4 | P10T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.31e-01 | 0.116 |
5210 | PFKFB4 | P12T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.26e-01 | 0.1122 |
5210 | PFKFB4 | P15T-E | Human | Esophagus | ESCC | 5.19e-07 | 1.83e-01 | 0.1149 |
5210 | PFKFB4 | P21T-E | Human | Esophagus | ESCC | 1.66e-02 | 6.36e-02 | 0.1617 |
5210 | PFKFB4 | P26T-E | Human | Esophagus | ESCC | 1.53e-19 | 4.27e-01 | 0.1276 |
5210 | PFKFB4 | P28T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.27e-01 | 0.1149 |
5210 | PFKFB4 | P32T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.26e-01 | 0.1666 |
5210 | PFKFB4 | P37T-E | Human | Esophagus | ESCC | 2.31e-05 | 1.56e-01 | 0.1371 |
5210 | PFKFB4 | P38T-E | Human | Esophagus | ESCC | 4.17e-18 | 6.59e-01 | 0.127 |
5210 | PFKFB4 | P42T-E | Human | Esophagus | ESCC | 3.05e-02 | 9.14e-02 | 0.1175 |
5210 | PFKFB4 | P49T-E | Human | Esophagus | ESCC | 3.28e-15 | 9.32e-01 | 0.1768 |
5210 | PFKFB4 | P74T-E | Human | Esophagus | ESCC | 1.42e-04 | 1.61e-01 | 0.1479 |
5210 | PFKFB4 | P79T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.73e-01 | 0.1154 |
5210 | PFKFB4 | P80T-E | Human | Esophagus | ESCC | 3.16e-03 | 1.22e-01 | 0.155 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0019318 | Colorectum | AD | hexose metabolic process | 77/3918 | 237/18723 | 1.96e-05 | 4.01e-04 | 77 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0005996 | Colorectum | AD | monosaccharide metabolic process | 80/3918 | 257/18723 | 7.31e-05 | 1.17e-03 | 80 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:00059969 | Esophagus | ESCC | monosaccharide metabolic process | 159/8552 | 257/18723 | 1.11e-07 | 1.81e-06 | 159 |
GO:00193189 | Esophagus | ESCC | hexose metabolic process | 147/8552 | 237/18723 | 2.63e-07 | 3.94e-06 | 147 |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa00051 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa000511 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa0415210 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
hsa000512 | Esophagus | ESCC | Fructose and mannose metabolism | 24/4205 | 34/8465 | 1.09e-02 | 2.51e-02 | 1.29e-02 | 24 |
hsa0415213 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
hsa0005111 | Esophagus | ESCC | Fructose and mannose metabolism | 24/4205 | 34/8465 | 1.09e-02 | 2.51e-02 | 1.29e-02 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PFKFB4 | SNV | Missense_Mutation | c.443A>C | p.Asn148Thr | p.N148T | Q16877 | protein_coding | benign(0.145) | TCGA-DM-A1D9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PFKFB4 | SNV | Missense_Mutation | c.1280C>T | p.Ala427Val | p.A427V | Q16877 | protein_coding | possibly_damaging(0.658) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PFKFB4 | SNV | Missense_Mutation | novel | c.650N>C | p.Lys217Thr | p.K217T | Q16877 | protein_coding | probably_damaging(0.993) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PFKFB4 | SNV | Missense_Mutation | c.103N>C | p.Met35Leu | p.M35L | Q16877 | protein_coding | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
PFKFB4 | SNV | Missense_Mutation | novel | c.526N>C | p.Ser176Arg | p.S176R | Q16877 | protein_coding | probably_damaging(0.985) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
PFKFB4 | SNV | Missense_Mutation | rs781144602 | c.1076G>A | p.Arg359Gln | p.R359Q | Q16877 | protein_coding | probably_damaging(0.998) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PFKFB4 | SNV | Missense_Mutation | novel | c.277N>A | p.Leu93Ile | p.L93I | Q16877 | protein_coding | benign(0.182) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PFKFB4 | SNV | Missense_Mutation | novel | c.557N>G | p.Glu186Gly | p.E186G | Q16877 | protein_coding | benign(0.38) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PFKFB4 | SNV | Missense_Mutation | novel | c.124N>G | p.Ile42Val | p.I42V | Q16877 | protein_coding | benign(0.073) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PFKFB4 | SNV | Missense_Mutation | novel | c.413N>A | p.Arg138Lys | p.R138K | Q16877 | protein_coding | probably_damaging(1) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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