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Gene: PELP1 |
Gene summary for PELP1 |
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Gene information | Species | Human | Gene symbol | PELP1 | Gene ID | 27043 |
Gene name | proline, glutamate and leucine rich protein 1 | |
Gene Alias | MNAR | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B4DEX7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27043 | PELP1 | LZE4T | Human | Esophagus | ESCC | 1.52e-08 | 3.07e-01 | 0.0811 |
27043 | PELP1 | LZE7T | Human | Esophagus | ESCC | 1.16e-10 | 5.69e-01 | 0.0667 |
27043 | PELP1 | LZE8T | Human | Esophagus | ESCC | 2.26e-06 | 1.43e-01 | 0.067 |
27043 | PELP1 | LZE22T | Human | Esophagus | ESCC | 2.68e-02 | 1.32e-01 | 0.068 |
27043 | PELP1 | LZE24T | Human | Esophagus | ESCC | 1.24e-21 | 4.76e-01 | 0.0596 |
27043 | PELP1 | LZE21T | Human | Esophagus | ESCC | 2.09e-03 | 3.18e-01 | 0.0655 |
27043 | PELP1 | LZE6T | Human | Esophagus | ESCC | 7.95e-08 | 2.50e-01 | 0.0845 |
27043 | PELP1 | P1T-E | Human | Esophagus | ESCC | 1.48e-07 | 3.41e-01 | 0.0875 |
27043 | PELP1 | P2T-E | Human | Esophagus | ESCC | 2.70e-27 | 5.63e-01 | 0.1177 |
27043 | PELP1 | P4T-E | Human | Esophagus | ESCC | 8.43e-22 | 5.19e-01 | 0.1323 |
27043 | PELP1 | P5T-E | Human | Esophagus | ESCC | 1.31e-10 | 2.09e-01 | 0.1327 |
27043 | PELP1 | P8T-E | Human | Esophagus | ESCC | 1.69e-20 | 4.16e-01 | 0.0889 |
27043 | PELP1 | P9T-E | Human | Esophagus | ESCC | 1.22e-07 | 2.12e-01 | 0.1131 |
27043 | PELP1 | P10T-E | Human | Esophagus | ESCC | 1.77e-16 | 2.56e-01 | 0.116 |
27043 | PELP1 | P11T-E | Human | Esophagus | ESCC | 5.33e-13 | 5.06e-01 | 0.1426 |
27043 | PELP1 | P12T-E | Human | Esophagus | ESCC | 1.16e-23 | 5.45e-01 | 0.1122 |
27043 | PELP1 | P15T-E | Human | Esophagus | ESCC | 3.77e-20 | 3.15e-01 | 0.1149 |
27043 | PELP1 | P16T-E | Human | Esophagus | ESCC | 1.71e-32 | 6.16e-01 | 0.1153 |
27043 | PELP1 | P17T-E | Human | Esophagus | ESCC | 5.35e-06 | 3.52e-01 | 0.1278 |
27043 | PELP1 | P19T-E | Human | Esophagus | ESCC | 1.12e-02 | 5.58e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00436275 | Esophagus | ESCC | response to estrogen | 45/8552 | 75/18723 | 8.75e-03 | 3.08e-02 | 45 |
GO:0043627 | Liver | Cirrhotic | response to estrogen | 30/4634 | 75/18723 | 2.52e-03 | 1.51e-02 | 30 |
GO:00436271 | Liver | HCC | response to estrogen | 44/7958 | 75/18723 | 3.44e-03 | 1.55e-02 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PELP1 | insertion | In_Frame_Ins | novel | c.3308_3309insAATTTTTGTATTTTTAGTAGAGGTGGG | p.Leu1103_Val1104insIlePheValPheLeuValGluValGly | p.L1103_V1104insIFVFLVEVG | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||||
PELP1 | insertion | In_Frame_Ins | novel | c.717_718insAGTGATCCTCCT | p.Pro239_Glu240insSerAspProPro | p.P239_E240insSDPP | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||||
PELP1 | insertion | Nonsense_Mutation | novel | c.715_716insTGGTCTTGAACTCCTGACCT | p.Pro239LeufsTer6 | p.P239Lfs*6 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||||
PELP1 | deletion | Frame_Shift_Del | novel | c.1146delT | p.Val384CysfsTer64 | p.V384Cfs*64 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
PELP1 | SNV | Missense_Mutation | novel | c.1244N>A | p.Arg415Gln | p.R415Q | protein_coding | tolerated(0.12) | benign(0.39) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PELP1 | SNV | Missense_Mutation | novel | c.2297N>A | p.Leu766Gln | p.L766Q | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.999) | TCGA-C5-A901-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PELP1 | SNV | Missense_Mutation | novel | c.2992G>C | p.Glu998Gln | p.E998Q | protein_coding | deleterious_low_confidence(0.04) | benign(0.271) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
PELP1 | SNV | Missense_Mutation | rs766876710 | c.2153C>T | p.Pro718Leu | p.P718L | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
PELP1 | SNV | Missense_Mutation | rs753210674 | c.2684N>T | p.Pro895Leu | p.P895L | protein_coding | deleterious_low_confidence(0.01) | benign(0.135) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PELP1 | SNV | Missense_Mutation | c.1628C>T | p.Ala543Val | p.A543V | protein_coding | deleterious(0.05) | probably_damaging(0.96) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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