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Gene: PDE12 |
Gene summary for PDE12 |
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Gene information | Species | Human | Gene symbol | PDE12 | Gene ID | 201626 |
Gene name | phosphodiesterase 12 | |
Gene Alias | 2'-PDE | |
Cytomap | 3p14.3 | |
Gene Type | protein-coding | GO ID | GO:0000288 | UniProtAcc | F6T1Q0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
201626 | PDE12 | HCC1_Meng | Human | Liver | HCC | 1.24e-41 | 3.37e-02 | 0.0246 |
201626 | PDE12 | HCC2_Meng | Human | Liver | HCC | 1.35e-06 | -1.40e-02 | 0.0107 |
201626 | PDE12 | HCC1 | Human | Liver | HCC | 1.47e-04 | 3.09e+00 | 0.5336 |
201626 | PDE12 | HCC2 | Human | Liver | HCC | 8.15e-05 | 1.92e+00 | 0.5341 |
201626 | PDE12 | S014 | Human | Liver | HCC | 1.59e-02 | 2.13e-01 | 0.2254 |
201626 | PDE12 | S016 | Human | Liver | HCC | 1.22e-05 | 3.12e-01 | 0.2243 |
201626 | PDE12 | S027 | Human | Liver | HCC | 1.64e-03 | 5.28e-01 | 0.2446 |
201626 | PDE12 | S028 | Human | Liver | HCC | 7.97e-14 | 6.99e-01 | 0.2503 |
201626 | PDE12 | S029 | Human | Liver | HCC | 1.21e-12 | 6.41e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:000989622 | Liver | HCC | positive regulation of catabolic process | 335/7958 | 492/18723 | 3.83e-31 | 1.87e-28 | 335 |
GO:003133122 | Liver | HCC | positive regulation of cellular catabolic process | 295/7958 | 427/18723 | 3.20e-29 | 1.45e-26 | 295 |
GO:001603222 | Liver | HCC | viral process | 286/7958 | 415/18723 | 4.41e-28 | 1.86e-25 | 286 |
GO:004427021 | Liver | HCC | cellular nitrogen compound catabolic process | 303/7958 | 451/18723 | 9.76e-27 | 3.64e-24 | 303 |
GO:004670021 | Liver | HCC | heterocycle catabolic process | 299/7958 | 445/18723 | 2.07e-26 | 7.29e-24 | 299 |
GO:190136121 | Liver | HCC | organic cyclic compound catabolic process | 325/7958 | 495/18723 | 6.52e-26 | 2.18e-23 | 325 |
GO:001943921 | Liver | HCC | aromatic compound catabolic process | 309/7958 | 467/18723 | 1.56e-25 | 4.94e-23 | 309 |
GO:000640121 | Liver | HCC | RNA catabolic process | 201/7958 | 278/18723 | 3.88e-24 | 1.02e-21 | 201 |
GO:003465521 | Liver | HCC | nucleobase-containing compound catabolic process | 273/7958 | 407/18723 | 4.84e-24 | 1.23e-21 | 273 |
GO:000906012 | Liver | HCC | aerobic respiration | 147/7958 | 189/18723 | 3.13e-23 | 6.61e-21 | 147 |
GO:190331121 | Liver | HCC | regulation of mRNA metabolic process | 205/7958 | 288/18723 | 3.38e-23 | 6.90e-21 | 205 |
GO:004533312 | Liver | HCC | cellular respiration | 171/7958 | 230/18723 | 6.35e-23 | 1.26e-20 | 171 |
GO:004603422 | Liver | HCC | ATP metabolic process | 198/7958 | 277/18723 | 8.30e-23 | 1.55e-20 | 198 |
GO:001598022 | Liver | HCC | energy derivation by oxidation of organic compounds | 221/7958 | 318/18723 | 1.02e-22 | 1.86e-20 | 221 |
GO:000640221 | Liver | HCC | mRNA catabolic process | 169/7958 | 232/18723 | 4.50e-21 | 6.96e-19 | 169 |
GO:000611912 | Liver | HCC | oxidative phosphorylation | 110/7958 | 141/18723 | 6.58e-18 | 7.45e-16 | 110 |
GO:001905822 | Liver | HCC | viral life cycle | 209/7958 | 317/18723 | 2.05e-17 | 2.09e-15 | 209 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:004348721 | Liver | HCC | regulation of RNA stability | 119/7958 | 170/18723 | 3.20e-13 | 1.71e-11 | 119 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE12 | SNV | Missense_Mutation | c.653C>T | p.Pro218Leu | p.P218L | Q6L8Q7 | protein_coding | tolerated(0.28) | benign(0.005) | TCGA-AA-A02J-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PDE12 | SNV | Missense_Mutation | c.571N>A | p.Ala191Thr | p.A191T | Q6L8Q7 | protein_coding | tolerated(0.59) | benign(0) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
PDE12 | SNV | Missense_Mutation | c.551N>A | p.Ser184Asn | p.S184N | Q6L8Q7 | protein_coding | tolerated(0.26) | benign(0.024) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
PDE12 | SNV | Missense_Mutation | c.1400N>A | p.Arg467His | p.R467H | Q6L8Q7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
PDE12 | SNV | Missense_Mutation | novel | c.1597N>C | p.Ser533Pro | p.S533P | Q6L8Q7 | protein_coding | tolerated(0.31) | benign(0.049) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDE12 | insertion | In_Frame_Ins | novel | c.267_268insAAT | p.Ala89_Ala90insAsn | p.A89_A90insN | Q6L8Q7 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PDE12 | SNV | Missense_Mutation | novel | c.1761N>A | p.His587Gln | p.H587Q | Q6L8Q7 | protein_coding | deleterious(0.01) | possibly_damaging(0.758) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDE12 | SNV | Missense_Mutation | c.460N>G | p.Lys154Glu | p.K154E | Q6L8Q7 | protein_coding | tolerated(0.13) | benign(0.01) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDE12 | SNV | Missense_Mutation | novel | c.1261T>C | p.Tyr421His | p.Y421H | Q6L8Q7 | protein_coding | tolerated(0.52) | benign(0.01) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
PDE12 | SNV | Missense_Mutation | novel | c.83N>A | p.Ser28Asn | p.S28N | Q6L8Q7 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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