![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PCYT1A |
Gene summary for PCYT1A |
![]() |
Gene information | Species | Human | Gene symbol | PCYT1A | Gene ID | 5130 |
Gene name | phosphate cytidylyltransferase 1A, choline | |
Gene Alias | CCTA | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | B4E322 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5130 | PCYT1A | HTA11_347_2000001011 | Human | Colorectum | AD | 1.03e-09 | 3.39e-01 | -0.1954 |
5130 | PCYT1A | LZE2T | Human | Esophagus | ESCC | 3.49e-02 | 5.00e-01 | 0.082 |
5130 | PCYT1A | LZE4T | Human | Esophagus | ESCC | 3.79e-30 | 1.07e+00 | 0.0811 |
5130 | PCYT1A | LZE7T | Human | Esophagus | ESCC | 1.60e-13 | 7.36e-01 | 0.0667 |
5130 | PCYT1A | LZE8T | Human | Esophagus | ESCC | 6.95e-08 | 2.34e-01 | 0.067 |
5130 | PCYT1A | LZE20T | Human | Esophagus | ESCC | 2.37e-05 | 2.70e-01 | 0.0662 |
5130 | PCYT1A | LZE22D1 | Human | Esophagus | HGIN | 4.07e-03 | 1.76e-01 | 0.0595 |
5130 | PCYT1A | LZE24T | Human | Esophagus | ESCC | 2.38e-27 | 8.36e-01 | 0.0596 |
5130 | PCYT1A | LZE21T | Human | Esophagus | ESCC | 5.01e-06 | 5.59e-01 | 0.0655 |
5130 | PCYT1A | LZE6T | Human | Esophagus | ESCC | 3.05e-03 | 2.49e-01 | 0.0845 |
5130 | PCYT1A | P1T-E | Human | Esophagus | ESCC | 3.14e-07 | 4.93e-01 | 0.0875 |
5130 | PCYT1A | P2T-E | Human | Esophagus | ESCC | 1.80e-26 | 5.60e-01 | 0.1177 |
5130 | PCYT1A | P4T-E | Human | Esophagus | ESCC | 8.82e-39 | 1.03e+00 | 0.1323 |
5130 | PCYT1A | P5T-E | Human | Esophagus | ESCC | 2.75e-34 | 7.10e-01 | 0.1327 |
5130 | PCYT1A | P8T-E | Human | Esophagus | ESCC | 2.60e-22 | 4.04e-01 | 0.0889 |
5130 | PCYT1A | P9T-E | Human | Esophagus | ESCC | 7.34e-44 | 9.89e-01 | 0.1131 |
5130 | PCYT1A | P10T-E | Human | Esophagus | ESCC | 2.75e-26 | 4.05e-01 | 0.116 |
5130 | PCYT1A | P11T-E | Human | Esophagus | ESCC | 1.70e-14 | 7.16e-01 | 0.1426 |
5130 | PCYT1A | P12T-E | Human | Esophagus | ESCC | 7.45e-22 | 4.61e-01 | 0.1122 |
5130 | PCYT1A | P15T-E | Human | Esophagus | ESCC | 1.48e-33 | 8.07e-01 | 0.1149 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00066561 | Esophagus | ESCC | phosphatidylcholine biosynthetic process | 24/8552 | 29/18723 | 4.50e-05 | 3.55e-04 | 24 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:00086542 | Liver | HCC | phospholipid biosynthetic process | 150/7958 | 253/18723 | 4.77e-08 | 1.03e-06 | 150 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
GO:004501711 | Liver | HCC | glycerolipid biosynthetic process | 143/7958 | 252/18723 | 3.27e-06 | 4.31e-05 | 143 |
GO:00066504 | Liver | HCC | glycerophospholipid metabolic process | 168/7958 | 306/18723 | 7.27e-06 | 8.62e-05 | 168 |
GO:004647411 | Liver | HCC | glycerophospholipid biosynthetic process | 121/7958 | 211/18723 | 9.12e-06 | 1.06e-04 | 121 |
GO:00086543 | Oral cavity | OSCC | phospholipid biosynthetic process | 130/7305 | 253/18723 | 3.96e-05 | 3.46e-04 | 130 |
GO:00464743 | Oral cavity | OSCC | glycerophospholipid biosynthetic process | 102/7305 | 211/18723 | 3.50e-03 | 1.48e-02 | 102 |
GO:00066445 | Oral cavity | OSCC | phospholipid metabolic process | 175/7305 | 383/18723 | 4.21e-03 | 1.71e-02 | 175 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052319 | Esophagus | ESCC | Choline metabolism in cancer | 61/4205 | 98/8465 | 7.97e-03 | 1.92e-02 | 9.84e-03 | 61 |
hsa0523114 | Esophagus | ESCC | Choline metabolism in cancer | 61/4205 | 98/8465 | 7.97e-03 | 1.92e-02 | 9.84e-03 | 61 |
hsa052316 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
hsa0523111 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCYT1A | SNV | Missense_Mutation | c.461N>T | p.Thr154Ile | p.T154I | P49585 | protein_coding | deleterious(0.01) | possibly_damaging(0.79) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PCYT1A | SNV | Missense_Mutation | c.109T>G | p.Cys37Gly | p.C37G | P49585 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-AG-3890-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PCYT1A | SNV | Missense_Mutation | novel | c.788T>G | p.Phe263Cys | p.F263C | P49585 | protein_coding | deleterious(0.01) | probably_damaging(0.942) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCYT1A | SNV | Missense_Mutation | novel | c.788N>G | p.Phe263Cys | p.F263C | P49585 | protein_coding | deleterious(0.01) | probably_damaging(0.942) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PCYT1A | insertion | Frame_Shift_Ins | rs771541186 | c.990_991insC | p.Ser331LeufsTer30 | p.S331Lfs*30 | P49585 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PCYT1A | SNV | Missense_Mutation | c.277N>A | p.Ala93Thr | p.A93T | P49585 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCYT1A | SNV | Missense_Mutation | novel | c.383N>C | p.Asn128Thr | p.N128T | P49585 | protein_coding | tolerated(0.4) | benign(0.02) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PCYT1A | SNV | Missense_Mutation | rs772948955 | c.107N>A | p.Arg36His | p.R36H | P49585 | protein_coding | tolerated(0.26) | benign(0.284) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PCYT1A | SNV | Missense_Mutation | c.394N>A | p.Arg132Ser | p.R132S | P49585 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCYT1A | SNV | Missense_Mutation | novel | c.935A>G | p.Gln312Arg | p.Q312R | P49585 | protein_coding | tolerated(0.19) | benign(0.236) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5130 | PCYT1A | ENZYME | lamivudine | LAMIVUDINE |
Page: 1 |