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Gene: PCED1B |
Gene summary for PCED1B |
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Gene information | Species | Human | Gene symbol | PCED1B | Gene ID | 91523 |
Gene name | PC-esterase domain containing 1B | |
Gene Alias | FAM113B | |
Cytomap | 12q13.11 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024R115 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91523 | PCED1B | CCI_1 | Human | Cervix | CC | 2.19e-05 | 5.13e-01 | 0.528 |
91523 | PCED1B | CCI_2 | Human | Cervix | CC | 2.26e-04 | 7.15e-01 | 0.5249 |
91523 | PCED1B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.42e-06 | 3.91e-01 | -0.0811 |
91523 | PCED1B | HTA11_78_2000001011 | Human | Colorectum | AD | 2.04e-14 | 5.56e-01 | -0.1088 |
91523 | PCED1B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.89e-04 | 2.93e-01 | -0.1001 |
91523 | PCED1B | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.97e-18 | 6.94e-01 | 0.0588 |
91523 | PCED1B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.30e-09 | 4.61e-01 | 0.281 |
91523 | PCED1B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.82e-03 | 1.73e-01 | 0.2585 |
91523 | PCED1B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.38e-13 | 3.83e-01 | 0.3005 |
91523 | PCED1B | CRC-1-8810 | Human | Colorectum | CRC | 1.39e-13 | 4.90e-01 | 0.6257 |
91523 | PCED1B | RNA-P17T-P17T-4 | Human | Lung | IAC | 3.43e-02 | 5.35e-01 | 0.343 |
91523 | PCED1B | RNA-P17T-P17T-8 | Human | Lung | IAC | 4.11e-02 | 3.30e-01 | 0.3329 |
91523 | PCED1B | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.02e-04 | 5.47e-01 | 0.1829 |
91523 | PCED1B | RNA-P3T-P3T-2 | Human | Lung | IAC | 1.95e-04 | 5.11e-01 | 0.1835 |
91523 | PCED1B | RNA-P3T-P3T-4 | Human | Lung | IAC | 5.97e-07 | 6.00e-01 | 0.1859 |
91523 | PCED1B | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 3.27e-04 | 9.05e-01 | -0.0186 |
91523 | PCED1B | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 1.56e-05 | 8.74e-01 | -0.0263 |
91523 | PCED1B | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 8.04e-18 | 6.19e-01 | -0.0166 |
91523 | PCED1B | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.76e-19 | 5.96e-01 | -0.0132 |
91523 | PCED1B | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 9.23e-21 | 6.08e-01 | -0.013 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCED1B | SNV | Missense_Mutation | novel | c.117N>T | p.Lys39Asn | p.K39N | Q96HM7 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PCED1B | SNV | Missense_Mutation | c.218G>A | p.Gly73Asp | p.G73D | Q96HM7 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PCED1B | SNV | Missense_Mutation | c.1072N>A | p.Asp358Asn | p.D358N | Q96HM7 | protein_coding | deleterious(0.05) | possibly_damaging(0.854) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PCED1B | SNV | Missense_Mutation | c.190G>C | p.Gly64Arg | p.G64R | Q96HM7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-JX-A5QV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PCED1B | SNV | Missense_Mutation | c.887N>T | p.Ser296Phe | p.S296F | Q96HM7 | protein_coding | tolerated(0.19) | benign(0.001) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PCED1B | SNV | Missense_Mutation | c.611N>T | p.Ala204Val | p.A204V | Q96HM7 | protein_coding | deleterious(0.04) | possibly_damaging(0.866) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PCED1B | SNV | Missense_Mutation | c.229N>T | p.Arg77Cys | p.R77C | Q96HM7 | protein_coding | deleterious(0.03) | probably_damaging(0.909) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCED1B | SNV | Missense_Mutation | c.661N>A | p.Ala221Thr | p.A221T | Q96HM7 | protein_coding | tolerated(0.06) | benign(0.168) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCED1B | SNV | Missense_Mutation | rs750197613 | c.601N>A | p.Ala201Thr | p.A201T | Q96HM7 | protein_coding | tolerated(0.13) | possibly_damaging(0.657) | TCGA-AG-4022-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PCED1B | SNV | Missense_Mutation | novel | c.332C>G | p.Ser111Trp | p.S111W | Q96HM7 | protein_coding | tolerated(0.2) | probably_damaging(0.973) | TCGA-AG-A02G-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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