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Gene: PCBP2 |
Gene summary for PCBP2 |
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Gene information | Species | Human | Gene symbol | PCBP2 | Gene ID | 5094 |
Gene name | poly(rC) binding protein 2 | |
Gene Alias | HNRNPE2 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q15366 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5094 | PCBP2 | CA_HPV_1 | Human | Cervix | CC | 3.13e-11 | -5.53e-02 | 0.0264 |
5094 | PCBP2 | CCI_1 | Human | Cervix | CC | 4.91e-02 | -4.02e-01 | 0.528 |
5094 | PCBP2 | CCI_3 | Human | Cervix | CC | 2.16e-04 | -5.07e-01 | 0.516 |
5094 | PCBP2 | CCII_1 | Human | Cervix | CC | 2.18e-07 | -5.20e-01 | 0.3249 |
5094 | PCBP2 | L1 | Human | Cervix | CC | 4.92e-02 | -2.73e-01 | 0.0802 |
5094 | PCBP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.31e-03 | -1.91e-01 | 0.0155 |
5094 | PCBP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.76e-06 | 4.27e-01 | -0.1954 |
5094 | PCBP2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.96e-03 | 3.79e-01 | 0.096 |
5094 | PCBP2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.16e-08 | 9.57e-01 | 0.0171 |
5094 | PCBP2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.96e-03 | 4.44e-01 | 0.0674 |
5094 | PCBP2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.04e-11 | 1.53e+00 | 0.3487 |
5094 | PCBP2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.75e-15 | 9.27e-01 | 0.281 |
5094 | PCBP2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.59e-05 | 6.63e-01 | 0.3859 |
5094 | PCBP2 | A002-C-010 | Human | Colorectum | FAP | 7.37e-06 | -1.45e-01 | 0.242 |
5094 | PCBP2 | A015-C-203 | Human | Colorectum | FAP | 1.45e-26 | -3.02e-01 | -0.1294 |
5094 | PCBP2 | A015-C-204 | Human | Colorectum | FAP | 3.82e-04 | -1.73e-01 | -0.0228 |
5094 | PCBP2 | A014-C-040 | Human | Colorectum | FAP | 5.56e-03 | -1.80e-01 | -0.1184 |
5094 | PCBP2 | A002-C-201 | Human | Colorectum | FAP | 1.56e-10 | -1.94e-01 | 0.0324 |
5094 | PCBP2 | A001-C-119 | Human | Colorectum | FAP | 3.42e-03 | -2.94e-01 | -0.1557 |
5094 | PCBP2 | A001-C-108 | Human | Colorectum | FAP | 7.48e-17 | -3.43e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
GO:001905810 | Cervix | CC | viral life cycle | 87/2311 | 317/18723 | 2.20e-13 | 1.20e-10 | 87 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:00026837 | Cervix | CC | negative regulation of immune system process | 94/2311 | 434/18723 | 2.63e-08 | 1.87e-06 | 94 |
GO:001907910 | Cervix | CC | viral genome replication | 35/2311 | 131/18723 | 6.11e-06 | 1.49e-04 | 35 |
GO:00028315 | Cervix | CC | regulation of response to biotic stimulus | 67/2311 | 327/18723 | 1.79e-05 | 3.36e-04 | 67 |
GO:00096158 | Cervix | CC | response to virus | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00028322 | Cervix | CC | negative regulation of response to biotic stimulus | 27/2311 | 108/18723 | 2.27e-04 | 2.55e-03 | 27 |
GO:00507773 | Cervix | CC | negative regulation of immune response | 41/2311 | 194/18723 | 3.63e-04 | 3.76e-03 | 41 |
GO:00321022 | Cervix | CC | negative regulation of response to external stimulus | 75/2311 | 420/18723 | 5.96e-04 | 5.61e-03 | 75 |
GO:0031348 | Cervix | CC | negative regulation of defense response | 48/2311 | 258/18723 | 2.30e-03 | 1.65e-02 | 48 |
GO:00190807 | Cervix | CC | viral gene expression | 21/2311 | 94/18723 | 4.68e-03 | 2.82e-02 | 21 |
GO:00190817 | Cervix | CC | viral translation | 6/2311 | 16/18723 | 9.35e-03 | 4.66e-02 | 6 |
GO:00516072 | Cervix | CC | defense response to virus | 46/2311 | 265/18723 | 1.04e-02 | 4.97e-02 | 46 |
GO:01405462 | Cervix | CC | defense response to symbiont | 46/2311 | 265/18723 | 1.04e-02 | 4.97e-02 | 46 |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421614 | Cervix | CC | Ferroptosis | 14/1267 | 41/8465 | 1.75e-03 | 7.21e-03 | 4.26e-03 | 14 |
hsa0421615 | Cervix | CC | Ferroptosis | 14/1267 | 41/8465 | 1.75e-03 | 7.21e-03 | 4.26e-03 | 14 |
hsa04216 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa042161 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa042162 | Colorectum | MSS | Ferroptosis | 18/1875 | 41/8465 | 1.53e-03 | 8.53e-03 | 5.23e-03 | 18 |
hsa042163 | Colorectum | MSS | Ferroptosis | 18/1875 | 41/8465 | 1.53e-03 | 8.53e-03 | 5.23e-03 | 18 |
hsa042164 | Colorectum | FAP | Ferroptosis | 18/1404 | 41/8465 | 3.49e-05 | 3.65e-04 | 2.22e-04 | 18 |
hsa042165 | Colorectum | FAP | Ferroptosis | 18/1404 | 41/8465 | 3.49e-05 | 3.65e-04 | 2.22e-04 | 18 |
hsa042166 | Colorectum | CRC | Ferroptosis | 13/1091 | 41/8465 | 1.36e-03 | 1.08e-02 | 7.33e-03 | 13 |
hsa042167 | Colorectum | CRC | Ferroptosis | 13/1091 | 41/8465 | 1.36e-03 | 1.08e-02 | 7.33e-03 | 13 |
hsa0421616 | Endometrium | AEH | Ferroptosis | 15/1197 | 41/8465 | 2.83e-04 | 2.30e-03 | 1.68e-03 | 15 |
hsa0421617 | Endometrium | AEH | Ferroptosis | 15/1197 | 41/8465 | 2.83e-04 | 2.30e-03 | 1.68e-03 | 15 |
hsa0421625 | Endometrium | EEC | Ferroptosis | 16/1237 | 41/8465 | 1.09e-04 | 1.08e-03 | 8.08e-04 | 16 |
hsa0421635 | Endometrium | EEC | Ferroptosis | 16/1237 | 41/8465 | 1.09e-04 | 1.08e-03 | 8.08e-04 | 16 |
hsa0421628 | Esophagus | HGIN | Ferroptosis | 15/1383 | 41/8465 | 1.35e-03 | 1.26e-02 | 1.00e-02 | 15 |
hsa04216111 | Esophagus | HGIN | Ferroptosis | 15/1383 | 41/8465 | 1.35e-03 | 1.26e-02 | 1.00e-02 | 15 |
hsa0421629 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa0421638 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa042168 | Liver | NAFLD | Ferroptosis | 12/1043 | 41/8465 | 2.98e-03 | 2.96e-02 | 2.39e-02 | 12 |
hsa0421611 | Liver | NAFLD | Ferroptosis | 12/1043 | 41/8465 | 2.98e-03 | 2.96e-02 | 2.39e-02 | 12 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCBP2 | SNV | Missense_Mutation | c.431G>A | p.Arg144Gln | p.R144Q | Q15366 | protein_coding | deleterious(0.04) | benign(0.368) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PCBP2 | SNV | Missense_Mutation | c.1079C>T | p.Thr360Met | p.T360M | Q15366 | protein_coding | tolerated(0.19) | benign(0.012) | TCGA-CI-6622-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
PCBP2 | deletion | Frame_Shift_Del | c.605delC | p.Thr202LysfsTer26 | p.T202Kfs*26 | Q15366 | protein_coding | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
PCBP2 | SNV | Missense_Mutation | novel | c.1021N>A | p.Ser341Thr | p.S341T | Q15366 | protein_coding | tolerated(0.6) | benign(0.07) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCBP2 | SNV | Missense_Mutation | c.508N>A | p.Leu170Ile | p.L170I | Q15366 | protein_coding | tolerated_low_confidence(0.41) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
PCBP2 | SNV | Missense_Mutation | novel | c.119G>A | p.Arg40His | p.R40H | Q15366 | protein_coding | deleterious(0.03) | benign(0.151) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
PCBP2 | SNV | Missense_Mutation | novel | c.920N>G | p.Gln307Arg | p.Q307R | Q15366 | protein_coding | tolerated(0.16) | benign(0.34) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCBP2 | SNV | Missense_Mutation | novel | c.523C>A | p.Pro175Thr | p.P175T | Q15366 | protein_coding | deleterious(0.01) | benign(0.034) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PCBP2 | SNV | Missense_Mutation | c.1006N>T | p.Val336Phe | p.V336F | Q15366 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-BK-A0C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PCBP2 | SNV | Missense_Mutation | c.869N>A | p.Ser290Tyr | p.S290Y | Q15366 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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