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Gene: PAX7 |
Gene summary for PAX7 |
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Gene information | Species | Human | Gene symbol | PAX7 | Gene ID | 5081 |
Gene name | paired box 7 | |
Gene Alias | HUP1 | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P23759 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5081 | PAX7 | LP16 | Human | Oral cavity | LP | 5.89e-05 | 4.99e-01 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAX7 | SNV | Missense_Mutation | novel | c.632T>C | p.Leu211Pro | p.L211P | P23759 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PAX7 | SNV | Missense_Mutation | c.518N>A | p.Ala173Glu | p.A173E | P23759 | protein_coding | tolerated(0.92) | benign(0.081) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAX7 | SNV | Missense_Mutation | rs375284574 | c.592C>T | p.Arg198Trp | p.R198W | P23759 | protein_coding | deleterious(0.03) | possibly_damaging(0.586) | TCGA-AF-A56N-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
PAX7 | SNV | Missense_Mutation | c.259C>A | p.Leu87Ile | p.L87I | P23759 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PAX7 | insertion | Frame_Shift_Ins | rs754858754 | c.900_901insC | p.Tyr303LeufsTer61 | p.Y303Lfs*61 | P23759 | protein_coding | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PAX7 | SNV | Missense_Mutation | novel | c.1541N>T | p.Ser514Ile | p.S514I | P23759 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAX7 | SNV | Missense_Mutation | c.580N>A | p.Asp194Asn | p.D194N | P23759 | protein_coding | tolerated(0.11) | benign(0.122) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAX7 | SNV | Missense_Mutation | novel | c.1155G>T | p.Gln385His | p.Q385H | P23759 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(1) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PAX7 | SNV | Missense_Mutation | c.1450C>T | p.Arg484Cys | p.R484C | P23759 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PAX7 | SNV | Missense_Mutation | novel | c.1106N>T | p.Ala369Val | p.A369V | P23759 | protein_coding | tolerated_low_confidence(0.1) | benign(0.244) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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