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Gene: PAPD7 |
Gene summary for PAPD7 |
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Gene information | Species | Human | Gene symbol | PAPD7 | Gene ID | 11044 |
Gene name | terminal nucleotidyltransferase 4A | |
Gene Alias | LAK-1 | |
Cytomap | 5p15.31 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | B7ZLL4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11044 | PAPD7 | HCC1_Meng | Human | Liver | HCC | 1.79e-03 | 2.18e-02 | 0.0246 |
11044 | PAPD7 | HCC2_Meng | Human | Liver | HCC | 2.84e-06 | 8.17e-02 | 0.0107 |
11044 | PAPD7 | HCC1 | Human | Liver | HCC | 2.25e-08 | 3.19e+00 | 0.5336 |
11044 | PAPD7 | HCC2 | Human | Liver | HCC | 4.49e-11 | 2.76e+00 | 0.5341 |
11044 | PAPD7 | Pt14.a | Human | Liver | HCC | 1.18e-02 | 2.22e-01 | 0.0169 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAPD7 | SNV | Missense_Mutation | c.506N>T | p.Arg169Ile | p.R169I | Q5XG87 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
PAPD7 | SNV | Missense_Mutation | c.832N>A | p.Glu278Lys | p.E278K | Q5XG87 | protein_coding | tolerated(0.06) | benign(0.156) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PAPD7 | SNV | Missense_Mutation | c.205N>T | p.Arg69Trp | p.R69W | Q5XG87 | protein_coding | tolerated(0.06) | benign(0.112) | TCGA-AG-3881-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAPD7 | SNV | Missense_Mutation | rs766876723 | c.55G>A | p.Glu19Lys | p.E19K | Q5XG87 | protein_coding | tolerated(0.18) | benign(0.416) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PAPD7 | SNV | Missense_Mutation | c.354G>T | p.Lys118Asn | p.K118N | Q5XG87 | protein_coding | deleterious(0.02) | possibly_damaging(0.733) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PAPD7 | SNV | Missense_Mutation | c.354N>T | p.Lys118Asn | p.K118N | Q5XG87 | protein_coding | deleterious(0.02) | possibly_damaging(0.733) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PAPD7 | insertion | Frame_Shift_Ins | novel | c.1578_1579insA | p.His529ThrfsTer? | p.H529Tfs*? | Q5XG87 | protein_coding | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
PAPD7 | SNV | Missense_Mutation | novel | c.1464N>T | p.Lys488Asn | p.K488N | Q5XG87 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.987) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PAPD7 | SNV | Missense_Mutation | novel | c.380N>G | p.Leu127Arg | p.L127R | Q5XG87 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAPD7 | SNV | Missense_Mutation | novel | c.575N>T | p.Arg192Ile | p.R192I | Q5XG87 | protein_coding | deleterious(0.04) | possibly_damaging(0.771) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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