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Gene: PAGR1 |
Gene summary for PAGR1 |
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Gene information | Species | Human | Gene symbol | PAGR1 | Gene ID | 79447 |
Gene name | PAXIP1 associated glutamate rich protein 1 | |
Gene Alias | C16orf53 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BTK6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79447 | PAGR1 | LZE2T | Human | Esophagus | ESCC | 3.94e-07 | 6.52e-01 | 0.082 |
79447 | PAGR1 | LZE4T | Human | Esophagus | ESCC | 2.35e-12 | 4.24e-01 | 0.0811 |
79447 | PAGR1 | LZE5T | Human | Esophagus | ESCC | 1.28e-07 | 4.41e-01 | 0.0514 |
79447 | PAGR1 | LZE7T | Human | Esophagus | ESCC | 6.11e-12 | 5.92e-01 | 0.0667 |
79447 | PAGR1 | LZE8T | Human | Esophagus | ESCC | 9.77e-06 | 2.44e-01 | 0.067 |
79447 | PAGR1 | LZE20T | Human | Esophagus | ESCC | 1.97e-04 | 2.19e-01 | 0.0662 |
79447 | PAGR1 | LZE22T | Human | Esophagus | ESCC | 1.28e-07 | 4.90e-01 | 0.068 |
79447 | PAGR1 | LZE24D1 | Human | Esophagus | HGIN | 3.66e-03 | 5.85e-01 | 0.054 |
79447 | PAGR1 | LZE24T | Human | Esophagus | ESCC | 5.96e-45 | 1.15e+00 | 0.0596 |
79447 | PAGR1 | LZE21T | Human | Esophagus | ESCC | 1.16e-05 | 4.49e-01 | 0.0655 |
79447 | PAGR1 | LZE6T | Human | Esophagus | ESCC | 2.19e-23 | 8.56e-01 | 0.0845 |
79447 | PAGR1 | P1T-E | Human | Esophagus | ESCC | 7.17e-16 | 6.28e-01 | 0.0875 |
79447 | PAGR1 | P2T-E | Human | Esophagus | ESCC | 2.25e-69 | 1.10e+00 | 0.1177 |
79447 | PAGR1 | P4T-E | Human | Esophagus | ESCC | 1.31e-36 | 8.12e-01 | 0.1323 |
79447 | PAGR1 | P5T-E | Human | Esophagus | ESCC | 2.28e-35 | 6.24e-01 | 0.1327 |
79447 | PAGR1 | P8T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.40e-01 | 0.0889 |
79447 | PAGR1 | P9T-E | Human | Esophagus | ESCC | 4.11e-15 | 3.32e-01 | 0.1131 |
79447 | PAGR1 | P10T-E | Human | Esophagus | ESCC | 1.53e-19 | 3.34e-01 | 0.116 |
79447 | PAGR1 | P11T-E | Human | Esophagus | ESCC | 5.37e-25 | 8.17e-01 | 0.1426 |
79447 | PAGR1 | P12T-E | Human | Esophagus | ESCC | 6.49e-58 | 9.08e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:0030522110 | Esophagus | ESCC | intracellular receptor signaling pathway | 170/8552 | 265/18723 | 8.58e-10 | 2.09e-08 | 170 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:0048545111 | Esophagus | ESCC | response to steroid hormone | 204/8552 | 339/18723 | 4.47e-08 | 8.11e-07 | 204 |
GO:004484314 | Esophagus | ESCC | cell cycle G1/S phase transition | 148/8552 | 241/18723 | 5.68e-07 | 7.48e-06 | 148 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:0071383110 | Esophagus | ESCC | cellular response to steroid hormone stimulus | 127/8552 | 204/18723 | 1.26e-06 | 1.55e-05 | 127 |
GO:19019896 | Esophagus | ESCC | positive regulation of cell cycle phase transition | 77/8552 | 115/18723 | 3.20e-06 | 3.58e-05 | 77 |
GO:00900689 | Esophagus | ESCC | positive regulation of cell cycle process | 142/8552 | 236/18723 | 4.79e-06 | 5.08e-05 | 142 |
GO:003051819 | Esophagus | ESCC | intracellular steroid hormone receptor signaling pathway | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
GO:004340119 | Esophagus | ESCC | steroid hormone mediated signaling pathway | 87/8552 | 136/18723 | 1.25e-05 | 1.15e-04 | 87 |
GO:00165718 | Esophagus | ESCC | histone methylation | 89/8552 | 141/18723 | 2.17e-05 | 1.87e-04 | 89 |
GO:00331438 | Esophagus | ESCC | regulation of intracellular steroid hormone receptor signaling pathway | 50/8552 | 74/18723 | 1.16e-04 | 8.04e-04 | 50 |
GO:003496814 | Esophagus | ESCC | histone lysine methylation | 72/8552 | 115/18723 | 1.85e-04 | 1.18e-03 | 72 |
GO:001802214 | Esophagus | ESCC | peptidyl-lysine methylation | 79/8552 | 131/18723 | 5.17e-04 | 2.86e-03 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAGR1 | SNV | Missense_Mutation | novel | c.313T>A | p.Trp105Arg | p.W105R | Q9BTK6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-ED-A97K-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
PAGR1 | SNV | Missense_Mutation | c.125C>T | p.Ser42Leu | p.S42L | Q9BTK6 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
PAGR1 | SNV | Missense_Mutation | novel | c.571N>A | p.Ser191Thr | p.S191T | Q9BTK6 | protein_coding | tolerated(0.15) | benign(0.41) | TCGA-43-2581-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
PAGR1 | SNV | Missense_Mutation | novel | c.145N>A | p.Glu49Lys | p.E49K | Q9BTK6 | protein_coding | tolerated(0.22) | benign(0.374) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PAGR1 | SNV | Missense_Mutation | novel | c.518N>G | p.Glu173Gly | p.E173G | Q9BTK6 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-CV-7255-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PAGR1 | deletion | Frame_Shift_Del | novel | c.507delN | p.Phe170LeufsTer6 | p.F170Lfs*6 | Q9BTK6 | protein_coding | TCGA-KU-A66S-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
PAGR1 | SNV | Missense_Mutation | c.497N>T | p.Thr166Met | p.T166M | Q9BTK6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PAGR1 | deletion | Frame_Shift_Del | novel | c.711delN | p.Pro239HisfsTer24 | p.P239Hfs*24 | Q9BTK6 | protein_coding | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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