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Gene: PAGE4 |
Gene summary for PAGE4 |
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Gene information | Species | Human | Gene symbol | PAGE4 | Gene ID | 9506 |
Gene name | PAGE family member 4 | |
Gene Alias | CT16.7 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | O60829 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9506 | PAGE4 | S44 | Human | Liver | HCC | 2.61e-12 | 1.33e+00 | -0.0083 |
9506 | PAGE4 | HCC5 | Human | Liver | HCC | 2.39e-14 | 4.24e+00 | 0.4932 |
9506 | PAGE4 | S014 | Human | Liver | HCC | 4.83e-58 | 1.83e+00 | 0.2254 |
9506 | PAGE4 | S015 | Human | Liver | HCC | 2.41e-32 | 1.49e+00 | 0.2375 |
9506 | PAGE4 | S016 | Human | Liver | HCC | 2.90e-48 | 1.64e+00 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697922 | Liver | HCC | response to oxidative stress | 281/7958 | 446/18723 | 9.75e-19 | 1.24e-16 | 281 |
GO:006219722 | Liver | HCC | cellular response to chemical stress | 216/7958 | 337/18723 | 6.86e-16 | 5.44e-14 | 216 |
GO:003459922 | Liver | HCC | cellular response to oxidative stress | 183/7958 | 288/18723 | 3.65e-13 | 1.93e-11 | 183 |
GO:003166722 | Liver | HCC | response to nutrient levels | 276/7958 | 474/18723 | 2.30e-12 | 1.08e-10 | 276 |
GO:004259421 | Liver | HCC | response to starvation | 121/7958 | 197/18723 | 6.08e-08 | 1.28e-06 | 121 |
GO:003109822 | Liver | HCC | stress-activated protein kinase signaling cascade | 138/7958 | 247/18723 | 1.43e-05 | 1.57e-04 | 138 |
GO:005140322 | Liver | HCC | stress-activated MAPK cascade | 134/7958 | 239/18723 | 1.50e-05 | 1.64e-04 | 134 |
GO:200037722 | Liver | HCC | regulation of reactive oxygen species metabolic process | 92/7958 | 157/18723 | 3.34e-05 | 3.35e-04 | 92 |
GO:007030222 | Liver | HCC | regulation of stress-activated protein kinase signaling cascade | 105/7958 | 195/18723 | 8.79e-04 | 5.20e-03 | 105 |
GO:003647312 | Liver | HCC | cell death in response to oxidative stress | 55/7958 | 95/18723 | 1.76e-03 | 9.12e-03 | 55 |
GO:003287222 | Liver | HCC | regulation of stress-activated MAPK cascade | 102/7958 | 192/18723 | 1.86e-03 | 9.49e-03 | 102 |
GO:007259312 | Liver | HCC | reactive oxygen species metabolic process | 124/7958 | 239/18723 | 2.05e-03 | 1.04e-02 | 124 |
GO:190288212 | Liver | HCC | regulation of response to oxidative stress | 55/7958 | 98/18723 | 4.46e-03 | 1.93e-02 | 55 |
GO:190040712 | Liver | HCC | regulation of cellular response to oxidative stress | 50/7958 | 89/18723 | 6.33e-03 | 2.58e-02 | 50 |
GO:190320112 | Liver | HCC | regulation of oxidative stress-induced cell death | 42/7958 | 74/18723 | 9.32e-03 | 3.57e-02 | 42 |
GO:2000378 | Liver | HCC | negative regulation of reactive oxygen species metabolic process | 31/7958 | 52/18723 | 9.52e-03 | 3.60e-02 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAGE4 | SNV | Missense_Mutation | novel | c.77C>A | p.Ala26Asp | p.A26D | O60829 | protein_coding | tolerated(0.26) | possibly_damaging(0.5) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PAGE4 | SNV | Missense_Mutation | c.256N>G | p.Pro86Ala | p.P86A | O60829 | protein_coding | tolerated(0.08) | probably_damaging(0.963) | TCGA-55-7724-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAGE4 | SNV | Missense_Mutation | novel | c.259C>A | p.Pro87Thr | p.P87T | O60829 | protein_coding | tolerated(0.05) | probably_damaging(0.977) | TCGA-L4-A4E5-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PAGE4 | SNV | Missense_Mutation | novel | c.232N>T | p.Gly78Cys | p.G78C | O60829 | protein_coding | deleterious(0) | benign(0.034) | TCGA-BA-4078-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PAGE4 | SNV | Missense_Mutation | novel | c.266C>T | p.Pro89Leu | p.P89L | O60829 | protein_coding | tolerated(1) | benign(0) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PAGE4 | SNV | Missense_Mutation | c.199G>C | p.Asp67His | p.D67H | O60829 | protein_coding | deleterious(0.02) | possibly_damaging(0.67) | TCGA-BR-7901-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PAGE4 | SNV | Missense_Mutation | c.215G>T | p.Arg72Leu | p.R72L | O60829 | protein_coding | tolerated(0.2) | benign(0) | TCGA-DJ-A2QB-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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