![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PAFAH1B2 |
Gene summary for PAFAH1B2 |
![]() |
Gene information | Species | Human | Gene symbol | PAFAH1B2 | Gene ID | 5049 |
Gene name | platelet activating factor acetylhydrolase 1b catalytic subunit 2 | |
Gene Alias | HEL-S-303 | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P68402 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5049 | PAFAH1B2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.87e-08 | 4.94e-01 | -0.1808 |
5049 | PAFAH1B2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.36e-15 | 7.73e-01 | -0.0811 |
5049 | PAFAH1B2 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.23e-05 | 4.36e-01 | -0.1088 |
5049 | PAFAH1B2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.36e-18 | 6.29e-01 | -0.1954 |
5049 | PAFAH1B2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.20e-02 | 6.47e-01 | -0.2602 |
5049 | PAFAH1B2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.94e-03 | 3.42e-01 | -0.1207 |
5049 | PAFAH1B2 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.02e-02 | 3.56e-01 | -0.1526 |
5049 | PAFAH1B2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.09e-04 | 3.65e-01 | -0.1464 |
5049 | PAFAH1B2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.15e-16 | 6.88e-01 | -0.059 |
5049 | PAFAH1B2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.48e-02 | 2.01e-01 | -0.0842 |
5049 | PAFAH1B2 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.88e-03 | 5.60e-01 | -0.0124 |
5049 | PAFAH1B2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.52e-10 | 4.98e-01 | 0.294 |
5049 | PAFAH1B2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.61e-07 | 5.30e-01 | 0.281 |
5049 | PAFAH1B2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.44e-16 | 7.18e-01 | 0.3859 |
5049 | PAFAH1B2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.42e-06 | 5.15e-01 | 0.2585 |
5049 | PAFAH1B2 | A015-C-203 | Human | Colorectum | FAP | 3.70e-10 | -1.69e-01 | -0.1294 |
5049 | PAFAH1B2 | A002-C-201 | Human | Colorectum | FAP | 1.80e-03 | -2.06e-01 | 0.0324 |
5049 | PAFAH1B2 | A002-C-203 | Human | Colorectum | FAP | 1.31e-03 | -7.27e-02 | 0.2786 |
5049 | PAFAH1B2 | A001-C-119 | Human | Colorectum | FAP | 1.50e-03 | -3.08e-01 | -0.1557 |
5049 | PAFAH1B2 | A001-C-108 | Human | Colorectum | FAP | 1.29e-06 | -1.62e-01 | -0.0272 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0016241 | Colorectum | AD | regulation of macroautophagy | 50/3918 | 141/18723 | 4.55e-05 | 7.92e-04 | 50 |
GO:0010508 | Colorectum | AD | positive regulation of autophagy | 43/3918 | 124/18723 | 2.64e-04 | 3.27e-03 | 43 |
GO:00098961 | Colorectum | SER | positive regulation of catabolic process | 132/2897 | 492/18723 | 4.16e-11 | 6.72e-09 | 132 |
GO:00313311 | Colorectum | SER | positive regulation of cellular catabolic process | 114/2897 | 427/18723 | 1.22e-09 | 1.27e-07 | 114 |
GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
GO:00160421 | Colorectum | SER | lipid catabolic process | 77/2897 | 320/18723 | 3.52e-05 | 9.18e-04 | 77 |
GO:00105061 | Colorectum | SER | regulation of autophagy | 74/2897 | 317/18723 | 1.39e-04 | 2.77e-03 | 74 |
GO:00162411 | Colorectum | SER | regulation of macroautophagy | 34/2897 | 141/18723 | 4.74e-03 | 3.72e-02 | 34 |
GO:00098962 | Colorectum | MSS | positive regulation of catabolic process | 163/3467 | 492/18723 | 3.10e-15 | 9.22e-13 | 163 |
GO:00313312 | Colorectum | MSS | positive regulation of cellular catabolic process | 140/3467 | 427/18723 | 7.02e-13 | 1.33e-10 | 140 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00105062 | Colorectum | MSS | regulation of autophagy | 95/3467 | 317/18723 | 4.36e-07 | 1.71e-05 | 95 |
GO:00162412 | Colorectum | MSS | regulation of macroautophagy | 44/3467 | 141/18723 | 1.88e-04 | 2.64e-03 | 44 |
GO:00160422 | Colorectum | MSS | lipid catabolic process | 77/3467 | 320/18723 | 7.43e-03 | 4.71e-02 | 77 |
GO:00098964 | Colorectum | FAP | positive regulation of catabolic process | 126/2622 | 492/18723 | 3.76e-12 | 2.56e-09 | 126 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAFAH1B2 | SNV | Missense_Mutation | rs745995174 | c.568G>A | p.Asp190Asn | p.D190N | P68402 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BG-A0VZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
PAFAH1B2 | SNV | Missense_Mutation | novel | c.89N>T | p.Arg30Ile | p.R30I | P68402 | protein_coding | deleterious(0) | benign(0.335) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PAFAH1B2 | SNV | Missense_Mutation | novel | c.365T>C | p.Val122Ala | p.V122A | P68402 | protein_coding | tolerated(0.24) | benign(0.073) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAFAH1B2 | SNV | Missense_Mutation | novel | c.428N>T | p.Gly143Val | p.G143V | P68402 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PAFAH1B2 | SNV | Missense_Mutation | rs752992388 | c.545N>T | p.Ser182Leu | p.S182L | P68402 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAFAH1B2 | SNV | Missense_Mutation | c.598N>T | p.Gly200Trp | p.G200W | P68402 | protein_coding | deleterious(0.02) | possibly_damaging(0.842) | TCGA-44-2655-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PAFAH1B2 | SNV | Missense_Mutation | c.427N>T | p.Gly143Cys | p.G143C | P68402 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-91-6831-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PAFAH1B2 | SNV | Missense_Mutation | c.220N>T | p.Gly74Trp | p.G74W | P68402 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PAFAH1B2 | SNV | Missense_Mutation | novel | c.53N>A | p.Ile18Asn | p.I18N | P68402 | protein_coding | tolerated(0.05) | benign(0.052) | TCGA-56-8082-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAFAH1B2 | SNV | Missense_Mutation | c.617N>A | p.Cys206Tyr | p.C206Y | P68402 | protein_coding | tolerated(0.08) | benign(0.124) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |