![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: OLA1 |
Gene summary for OLA1 |
![]() |
Gene information | Species | Human | Gene symbol | OLA1 | Gene ID | 29789 |
Gene name | Obg like ATPase 1 | |
Gene Alias | DOC45 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9NTK5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29789 | OLA1 | CCI_2 | Human | Cervix | CC | 3.30e-11 | 1.27e+00 | 0.5249 |
29789 | OLA1 | CCI_3 | Human | Cervix | CC | 4.42e-03 | 5.24e-01 | 0.516 |
29789 | OLA1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.01e-09 | -4.05e-01 | 0.0155 |
29789 | OLA1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.21e-02 | -5.17e-01 | -0.1207 |
29789 | OLA1 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.77e-03 | -3.78e-01 | -0.1526 |
29789 | OLA1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.15e-04 | -3.91e-01 | -0.1464 |
29789 | OLA1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.80e-10 | -4.38e-01 | -0.1001 |
29789 | OLA1 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.92e-05 | -4.23e-01 | -0.0842 |
29789 | OLA1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.82e-02 | -5.70e-01 | 0.0528 |
29789 | OLA1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.06e-07 | -4.49e-01 | 0.0338 |
29789 | OLA1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.16e-11 | -5.07e-01 | 0.0674 |
29789 | OLA1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.75e-06 | 1.03e+00 | 0.3487 |
29789 | OLA1 | A001-C-207 | Human | Colorectum | FAP | 2.78e-05 | -3.45e-01 | 0.1278 |
29789 | OLA1 | A015-C-203 | Human | Colorectum | FAP | 6.86e-34 | -4.97e-01 | -0.1294 |
29789 | OLA1 | A015-C-204 | Human | Colorectum | FAP | 1.54e-06 | -3.63e-01 | -0.0228 |
29789 | OLA1 | A014-C-040 | Human | Colorectum | FAP | 2.64e-06 | -5.41e-01 | -0.1184 |
29789 | OLA1 | A002-C-201 | Human | Colorectum | FAP | 1.24e-17 | -5.10e-01 | 0.0324 |
29789 | OLA1 | A002-C-203 | Human | Colorectum | FAP | 3.75e-06 | -3.20e-01 | 0.2786 |
29789 | OLA1 | A001-C-119 | Human | Colorectum | FAP | 1.27e-14 | -6.71e-01 | -0.1557 |
29789 | OLA1 | A001-C-108 | Human | Colorectum | FAP | 4.01e-30 | -5.70e-01 | -0.0272 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603410 | Cervix | CC | ATP metabolic process | 90/2311 | 277/18723 | 7.90e-19 | 2.36e-15 | 90 |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
GO:00324791 | Cervix | CC | regulation of type I interferon production | 21/2311 | 95/18723 | 5.32e-03 | 3.10e-02 | 21 |
GO:00326061 | Cervix | CC | type I interferon production | 21/2311 | 95/18723 | 5.32e-03 | 3.10e-02 | 21 |
GO:0046034 | Colorectum | AD | ATP metabolic process | 142/3918 | 277/18723 | 2.64e-29 | 8.26e-26 | 142 |
GO:00460341 | Colorectum | SER | ATP metabolic process | 117/2897 | 277/18723 | 5.54e-27 | 1.13e-23 | 117 |
GO:00460343 | Colorectum | MSI-H | ATP metabolic process | 71/1319 | 277/18723 | 3.18e-22 | 8.32e-19 | 71 |
GO:00460344 | Colorectum | FAP | ATP metabolic process | 87/2622 | 277/18723 | 6.50e-14 | 6.63e-11 | 87 |
GO:00460345 | Colorectum | CRC | ATP metabolic process | 51/2078 | 277/18723 | 1.92e-04 | 3.30e-03 | 51 |
GO:00718977 | Endometrium | AEH | DNA biosynthetic process | 37/2100 | 180/18723 | 1.87e-04 | 2.39e-03 | 37 |
GO:004603427 | Esophagus | HGIN | ATP metabolic process | 101/2587 | 277/18723 | 1.53e-21 | 1.02e-18 | 101 |
GO:0046034111 | Esophagus | ESCC | ATP metabolic process | 189/8552 | 277/18723 | 1.99e-14 | 1.04e-12 | 189 |
GO:004603412 | Liver | Cirrhotic | ATP metabolic process | 144/4634 | 277/18723 | 1.04e-22 | 5.02e-20 | 144 |
GO:004603422 | Liver | HCC | ATP metabolic process | 198/7958 | 277/18723 | 8.30e-23 | 1.55e-20 | 198 |
GO:00460348 | Lung | IAC | ATP metabolic process | 49/2061 | 277/18723 | 5.44e-04 | 7.59e-03 | 49 |
GO:004603413 | Lung | AIS | ATP metabolic process | 42/1849 | 277/18723 | 3.31e-03 | 3.16e-02 | 42 |
GO:004603420 | Oral cavity | OSCC | ATP metabolic process | 166/7305 | 277/18723 | 1.16e-12 | 5.12e-11 | 166 |
GO:0046034110 | Oral cavity | LP | ATP metabolic process | 128/4623 | 277/18723 | 3.95e-15 | 5.38e-13 | 128 |
GO:004603426 | Oral cavity | EOLP | ATP metabolic process | 68/2218 | 277/18723 | 2.72e-09 | 1.71e-07 | 68 |
GO:004603433 | Oral cavity | NEOLP | ATP metabolic process | 71/2005 | 277/18723 | 1.44e-12 | 3.17e-10 | 71 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OLA1 | SNV | Missense_Mutation | c.647A>G | p.Lys216Arg | p.K216R | Q9NTK5 | protein_coding | tolerated(0.11) | benign(0.139) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
OLA1 | SNV | Missense_Mutation | c.919N>C | p.Tyr307His | p.Y307H | Q9NTK5 | protein_coding | tolerated(0.33) | probably_damaging(1) | TCGA-DY-A1DG-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
OLA1 | SNV | Missense_Mutation | novel | c.46N>G | p.Ile16Val | p.I16V | Q9NTK5 | protein_coding | deleterious(0.02) | possibly_damaging(0.456) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
OLA1 | SNV | Missense_Mutation | rs549904049 | c.403G>A | p.Val135Ile | p.V135I | Q9NTK5 | protein_coding | tolerated(0.13) | benign(0.019) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OLA1 | SNV | Missense_Mutation | novel | c.737N>C | p.Lys246Thr | p.K246T | Q9NTK5 | protein_coding | deleterious(0) | benign(0.436) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OLA1 | SNV | Missense_Mutation | c.601N>T | p.Arg201Cys | p.R201C | Q9NTK5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
OLA1 | SNV | Missense_Mutation | c.772G>A | p.Ala258Thr | p.A258T | Q9NTK5 | protein_coding | tolerated(0.45) | possibly_damaging(0.703) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OLA1 | SNV | Missense_Mutation | novel | c.893C>T | p.Ala298Val | p.A298V | Q9NTK5 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
OLA1 | SNV | Missense_Mutation | c.1118N>T | p.Arg373Ile | p.R373I | Q9NTK5 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
OLA1 | SNV | Missense_Mutation | novel | c.760N>C | p.Tyr254His | p.Y254H | Q9NTK5 | protein_coding | tolerated(1) | benign(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |