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Gene: OCEL1 |
Gene summary for OCEL1 |
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Gene information | Species | Human | Gene symbol | OCEL1 | Gene ID | 79629 |
Gene name | occludin/ELL domain containing 1 | |
Gene Alias | FWP009 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q9H607 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79629 | OCEL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.88e-05 | 2.77e-01 | -0.1808 |
79629 | OCEL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.05e-06 | 2.55e-01 | -0.1954 |
79629 | OCEL1 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.19e-04 | 6.08e-01 | -0.2602 |
79629 | OCEL1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.29e-03 | 2.96e-01 | -0.1207 |
79629 | OCEL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.01e-04 | 2.16e-01 | -0.1464 |
79629 | OCEL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.53e-05 | 2.69e-01 | -0.059 |
79629 | OCEL1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.12e-04 | 3.79e-01 | -0.2061 |
79629 | OCEL1 | LZE4T | Human | Esophagus | ESCC | 1.37e-03 | 1.72e-01 | 0.0811 |
79629 | OCEL1 | LZE7T | Human | Esophagus | ESCC | 3.41e-02 | 1.18e-01 | 0.0667 |
79629 | OCEL1 | LZE20T | Human | Esophagus | ESCC | 6.46e-03 | 1.13e-01 | 0.0662 |
79629 | OCEL1 | LZE24T | Human | Esophagus | ESCC | 2.45e-12 | 5.10e-01 | 0.0596 |
79629 | OCEL1 | LZE21T | Human | Esophagus | ESCC | 5.59e-03 | 1.66e-01 | 0.0655 |
79629 | OCEL1 | LZE6T | Human | Esophagus | ESCC | 7.10e-04 | 2.26e-01 | 0.0845 |
79629 | OCEL1 | P1T-E | Human | Esophagus | ESCC | 1.78e-11 | 3.91e-01 | 0.0875 |
79629 | OCEL1 | P2T-E | Human | Esophagus | ESCC | 2.81e-07 | 6.24e-02 | 0.1177 |
79629 | OCEL1 | P4T-E | Human | Esophagus | ESCC | 1.41e-09 | 2.39e-01 | 0.1323 |
79629 | OCEL1 | P5T-E | Human | Esophagus | ESCC | 4.44e-20 | 2.99e-01 | 0.1327 |
79629 | OCEL1 | P8T-E | Human | Esophagus | ESCC | 1.03e-24 | 5.20e-01 | 0.0889 |
79629 | OCEL1 | P9T-E | Human | Esophagus | ESCC | 8.67e-06 | 9.52e-02 | 0.1131 |
79629 | OCEL1 | P10T-E | Human | Esophagus | ESCC | 6.28e-12 | 1.65e-01 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OCEL1 | SNV | Missense_Mutation | c.319N>T | p.His107Tyr | p.H107Y | Q9H607 | protein_coding | tolerated(0.29) | benign(0) | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
OCEL1 | SNV | Missense_Mutation | novel | c.680G>A | p.Gly227Asp | p.G227D | Q9H607 | protein_coding | deleterious(0.04) | benign(0.346) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OCEL1 | SNV | Missense_Mutation | rs368314653 | c.355N>A | p.Glu119Lys | p.E119K | Q9H607 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-D1-A17D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
OCEL1 | SNV | Missense_Mutation | rs370272692 | c.490N>T | p.Arg164Cys | p.R164C | Q9H607 | protein_coding | tolerated(0.12) | benign(0.27) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
OCEL1 | deletion | Frame_Shift_Del | novel | c.641delN | p.Val215PhefsTer7 | p.V215Ffs*7 | Q9H607 | protein_coding | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
OCEL1 | insertion | Frame_Shift_Ins | rs761699990 | c.283_284insC | p.Arg97ProfsTer21 | p.R97Pfs*21 | Q9H607 | protein_coding | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
OCEL1 | SNV | Missense_Mutation | c.398N>C | p.Gly133Ala | p.G133A | Q9H607 | protein_coding | tolerated(0.28) | benign(0.026) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
OCEL1 | SNV | Missense_Mutation | novel | c.49N>A | p.Glu17Lys | p.E17K | Q9H607 | protein_coding | deleterious_low_confidence(0.01) | benign(0.269) | TCGA-91-6830-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
OCEL1 | SNV | Missense_Mutation | novel | c.349G>C | p.Glu117Gln | p.E117Q | Q9H607 | protein_coding | tolerated(0.08) | benign(0.326) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
OCEL1 | SNV | Missense_Mutation | novel | c.8N>G | p.Asn3Ser | p.N3S | Q9H607 | protein_coding | tolerated_low_confidence(0.06) | benign(0.001) | TCGA-NJ-A4YG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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