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Gene: OAZ1 |
Gene summary for OAZ1 |
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Gene information | Species | Human | Gene symbol | OAZ1 | Gene ID | 4946 |
Gene name | ornithine decarboxylase antizyme 1 | |
Gene Alias | AZ1 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006576 | UniProtAcc | J3QQY4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4946 | OAZ1 | CA_HPV_1 | Human | Cervix | CC | 3.55e-07 | 1.32e-01 | 0.0264 |
4946 | OAZ1 | CA_HPV_3 | Human | Cervix | CC | 1.36e-04 | 4.16e-02 | 0.0414 |
4946 | OAZ1 | CCI_1 | Human | Cervix | CC | 4.85e-41 | -1.51e+00 | 0.528 |
4946 | OAZ1 | CCI_2 | Human | Cervix | CC | 1.76e-38 | -1.51e+00 | 0.5249 |
4946 | OAZ1 | CCI_3 | Human | Cervix | CC | 4.02e-51 | -1.51e+00 | 0.516 |
4946 | OAZ1 | CCII_1 | Human | Cervix | CC | 5.82e-66 | -1.51e+00 | 0.3249 |
4946 | OAZ1 | sample3 | Human | Cervix | CC | 7.40e-05 | 3.03e-02 | 0.1387 |
4946 | OAZ1 | H2 | Human | Cervix | HSIL_HPV | 2.44e-16 | -4.49e-01 | 0.0632 |
4946 | OAZ1 | L1 | Human | Cervix | CC | 5.92e-06 | -2.16e-03 | 0.0802 |
4946 | OAZ1 | T3 | Human | Cervix | CC | 3.37e-05 | 1.97e-02 | 0.1389 |
4946 | OAZ1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.28e-75 | 1.14e+00 | 0.0155 |
4946 | OAZ1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.74e-77 | 2.12e+00 | -0.1808 |
4946 | OAZ1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.92e-31 | 1.39e+00 | 0.0216 |
4946 | OAZ1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.91e-65 | 1.90e+00 | -0.0811 |
4946 | OAZ1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.98e-63 | 1.41e+00 | -0.1088 |
4946 | OAZ1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.79e-111 | 1.89e+00 | -0.1954 |
4946 | OAZ1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.57e-38 | 2.68e+00 | -0.2602 |
4946 | OAZ1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.93e-37 | 2.15e+00 | -0.2196 |
4946 | OAZ1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.75e-64 | 1.73e+00 | -0.1207 |
4946 | OAZ1 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.72e-62 | 1.77e+00 | -0.1526 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:004573210 | Cervix | CC | positive regulation of protein catabolic process | 65/2311 | 231/18723 | 7.44e-11 | 1.39e-08 | 65 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:005122210 | Cervix | CC | positive regulation of protein transport | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:190495110 | Cervix | CC | positive regulation of establishment of protein localization | 73/2311 | 319/18723 | 9.69e-08 | 5.25e-06 | 73 |
GO:00903167 | Cervix | CC | positive regulation of intracellular protein transport | 41/2311 | 160/18723 | 3.24e-06 | 8.80e-05 | 41 |
GO:00323868 | Cervix | CC | regulation of intracellular transport | 71/2311 | 337/18723 | 3.70e-06 | 9.74e-05 | 71 |
GO:00331579 | Cervix | CC | regulation of intracellular protein transport | 52/2311 | 229/18723 | 8.16e-06 | 1.88e-04 | 52 |
GO:00323889 | Cervix | CC | positive regulation of intracellular transport | 46/2311 | 202/18723 | 2.45e-05 | 4.24e-04 | 46 |
GO:004217615 | Cervix | HSIL_HPV | regulation of protein catabolic process | 34/737 | 391/18723 | 1.41e-05 | 4.41e-04 | 34 |
GO:004573215 | Cervix | HSIL_HPV | positive regulation of protein catabolic process | 22/737 | 231/18723 | 1.24e-04 | 2.49e-03 | 22 |
GO:005122214 | Cervix | HSIL_HPV | positive regulation of protein transport | 23/737 | 303/18723 | 2.11e-03 | 2.17e-02 | 23 |
GO:190495114 | Cervix | HSIL_HPV | positive regulation of establishment of protein localization | 23/737 | 319/18723 | 4.01e-03 | 3.45e-02 | 23 |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:0045732 | Colorectum | AD | positive regulation of protein catabolic process | 92/3918 | 231/18723 | 3.85e-11 | 4.47e-09 | 92 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0090316 | Colorectum | AD | positive regulation of intracellular protein transport | 62/3918 | 160/18723 | 1.82e-07 | 7.79e-06 | 62 |
GO:0032388 | Colorectum | AD | positive regulation of intracellular transport | 74/3918 | 202/18723 | 1.83e-07 | 7.80e-06 | 74 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OAZ1 | SNV | Missense_Mutation | c.484T>A | p.Phe162Ile | p.F162I | P54368 | protein_coding | deleterious(0) | benign(0.293) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
OAZ1 | SNV | Missense_Mutation | novel | c.455G>A | p.Ser152Asn | p.S152N | P54368 | protein_coding | tolerated(0.15) | possibly_damaging(0.446) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
OAZ1 | deletion | Frame_Shift_Del | novel | c.280delN | p.Leu94TyrfsTer8 | p.L94Yfs*8 | P54368 | protein_coding | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
OAZ1 | SNV | Missense_Mutation | novel | c.602G>T | p.Gly201Val | p.G201V | P54368 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
OAZ1 | SNV | Missense_Mutation | novel | c.214C>G | p.His72Asp | p.H72D | P54368 | protein_coding | deleterious(0.01) | possibly_damaging(0.856) | TCGA-56-8503-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OAZ1 | SNV | Missense_Mutation | novel | c.255G>T | p.Gln85His | p.Q85H | P54368 | protein_coding | deleterious(0.04) | possibly_damaging(0.825) | TCGA-58-8386-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
OAZ1 | SNV | Missense_Mutation | novel | c.563N>A | p.Arg188Gln | p.R188Q | P54368 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-63-A5MR-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OAZ1 | SNV | Missense_Mutation | novel | c.661N>A | p.Glu221Lys | p.E221K | P54368 | protein_coding | deleterious(0.02) | benign(0.025) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OAZ1 | SNV | Missense_Mutation | rs770513984 | c.436N>A | p.Gly146Ser | p.G146S | P54368 | protein_coding | deleterious(0.05) | possibly_damaging(0.836) | TCGA-HU-A4GD-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD |
OAZ1 | SNV | Missense_Mutation | novel | c.280T>G | p.Leu94Val | p.L94V | P54368 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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