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Gene: NXPE1 |
Gene summary for NXPE1 |
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Gene information | Species | Human | Gene symbol | NXPE1 | Gene ID | 120400 |
Gene name | neurexophilin and PC-esterase domain family member 1 | |
Gene Alias | FAM55A | |
Cytomap | 11q23.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8N323 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
120400 | NXPE1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.04e-05 | -4.93e-01 | 0.0155 |
120400 | NXPE1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.38e-03 | -3.04e-01 | -0.1808 |
120400 | NXPE1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.88e-17 | -1.33e+00 | 0.0216 |
120400 | NXPE1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.43e-25 | 1.39e+00 | -0.1954 |
120400 | NXPE1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.08e-19 | 8.18e-01 | -0.2602 |
120400 | NXPE1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.63e-05 | -5.81e-01 | -0.1207 |
120400 | NXPE1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.20e-06 | 2.31e-01 | -0.1464 |
120400 | NXPE1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.82e-09 | 4.53e-01 | -0.1001 |
120400 | NXPE1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.84e-11 | -6.74e-01 | -0.059 |
120400 | NXPE1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.19e-03 | 4.52e-01 | -0.0842 |
120400 | NXPE1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.66e-07 | 8.34e-01 | -0.0179 |
120400 | NXPE1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.55e-31 | -1.07e+00 | 0.096 |
120400 | NXPE1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.79e-02 | -2.78e-01 | 0.0446 |
120400 | NXPE1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.21e-12 | -1.47e+00 | 0.0451 |
120400 | NXPE1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.46e-02 | -6.84e-01 | 0.0528 |
120400 | NXPE1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.30e-05 | 5.91e-01 | -0.0177 |
120400 | NXPE1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.16e-07 | -1.05e+00 | 0.0171 |
120400 | NXPE1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.66e-21 | -1.02e+00 | 0.0338 |
120400 | NXPE1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.48e-26 | -7.11e-01 | 0.0674 |
120400 | NXPE1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.85e-13 | -8.91e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NXPE1 | SNV | Missense_Mutation | novel | c.787T>C | p.Phe263Leu | p.F263L | Q8N323 | protein_coding | tolerated(0.45) | benign(0.107) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NXPE1 | SNV | Missense_Mutation | c.497N>G | p.Gln166Arg | p.Q166R | Q8N323 | protein_coding | tolerated(0.33) | benign(0.005) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NXPE1 | SNV | Missense_Mutation | c.451G>A | p.Asp151Asn | p.D151N | Q8N323 | protein_coding | tolerated(0.5) | benign(0) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
NXPE1 | SNV | Missense_Mutation | novel | c.1032G>T | p.Glu344Asp | p.E344D | Q8N323 | protein_coding | tolerated(1) | benign(0) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NXPE1 | SNV | Missense_Mutation | c.512N>T | p.Pro171Leu | p.P171L | Q8N323 | protein_coding | tolerated(0.65) | benign(0.007) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NXPE1 | SNV | Missense_Mutation | novel | c.700N>A | p.Leu234Ile | p.L234I | Q8N323 | protein_coding | tolerated(0.11) | possibly_damaging(0.612) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NXPE1 | SNV | Missense_Mutation | novel | c.1066N>A | p.His356Asn | p.H356N | Q8N323 | protein_coding | deleterious(0.02) | benign(0.005) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
NXPE1 | SNV | Missense_Mutation | novel | c.145N>T | p.Ala49Ser | p.A49S | Q8N323 | protein_coding | deleterious(0.05) | probably_damaging(0.923) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
NXPE1 | SNV | Missense_Mutation | rs115946153 | c.847C>T | p.Arg283Trp | p.R283W | Q8N323 | protein_coding | tolerated(0.15) | benign(0.077) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NXPE1 | SNV | Missense_Mutation | c.1196T>C | p.Met399Thr | p.M399T | Q8N323 | protein_coding | deleterious(0.01) | possibly_damaging(0.876) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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