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Gene: NUDT8 |
Gene summary for NUDT8 |
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Gene information | Species | Human | Gene symbol | NUDT8 | Gene ID | 254552 |
Gene name | nudix hydrolase 8 | |
Gene Alias | NUDT8 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q8WV74 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
254552 | NUDT8 | GSM4909282 | Human | Breast | IDC | 2.77e-07 | 4.14e-01 | -0.0288 |
254552 | NUDT8 | GSM4909290 | Human | Breast | IDC | 5.31e-43 | 1.03e+00 | 0.2096 |
254552 | NUDT8 | GSM4909294 | Human | Breast | IDC | 7.39e-17 | 7.04e-01 | 0.2022 |
254552 | NUDT8 | GSM4909296 | Human | Breast | IDC | 2.05e-02 | -6.05e-02 | 0.1524 |
254552 | NUDT8 | GSM4909297 | Human | Breast | IDC | 2.25e-03 | -9.53e-02 | 0.1517 |
254552 | NUDT8 | GSM4909311 | Human | Breast | IDC | 1.38e-04 | -9.11e-02 | 0.1534 |
254552 | NUDT8 | GSM4909312 | Human | Breast | IDC | 1.69e-02 | -2.53e-02 | 0.1552 |
254552 | NUDT8 | GSM4909315 | Human | Breast | IDC | 6.96e-19 | 6.61e-01 | 0.21 |
254552 | NUDT8 | GSM4909316 | Human | Breast | IDC | 7.65e-05 | 4.49e-01 | 0.21 |
254552 | NUDT8 | GSM4909319 | Human | Breast | IDC | 6.19e-10 | -3.63e-02 | 0.1563 |
254552 | NUDT8 | GSM4909321 | Human | Breast | IDC | 1.89e-03 | -3.68e-02 | 0.1559 |
254552 | NUDT8 | NCCBC6 | Human | Breast | DCIS | 1.48e-24 | 1.30e+00 | 0.2095 |
254552 | NUDT8 | DCIS2 | Human | Breast | DCIS | 1.16e-14 | 5.65e-02 | 0.0085 |
254552 | NUDT8 | LZE4T | Human | Esophagus | ESCC | 4.06e-06 | 1.13e-01 | 0.0811 |
254552 | NUDT8 | LZE20T | Human | Esophagus | ESCC | 7.57e-24 | 7.62e-01 | 0.0662 |
254552 | NUDT8 | LZE22D1 | Human | Esophagus | HGIN | 1.39e-07 | 4.50e-01 | 0.0595 |
254552 | NUDT8 | LZE22T | Human | Esophagus | ESCC | 3.60e-08 | 6.14e-01 | 0.068 |
254552 | NUDT8 | LZE24T | Human | Esophagus | ESCC | 2.76e-13 | 4.40e-01 | 0.0596 |
254552 | NUDT8 | LZE21T | Human | Esophagus | ESCC | 8.25e-07 | 3.48e-01 | 0.0655 |
254552 | NUDT8 | P1T-E | Human | Esophagus | ESCC | 5.18e-16 | 7.63e-01 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000915014 | Breast | IDC | purine ribonucleotide metabolic process | 55/1434 | 368/18723 | 1.30e-06 | 5.72e-05 | 55 |
GO:001969314 | Breast | IDC | ribose phosphate metabolic process | 58/1434 | 396/18723 | 1.31e-06 | 5.73e-05 | 58 |
GO:000675313 | Breast | IDC | nucleoside phosphate metabolic process | 68/1434 | 497/18723 | 2.01e-06 | 8.23e-05 | 68 |
GO:000911713 | Breast | IDC | nucleotide metabolic process | 67/1434 | 489/18723 | 2.28e-06 | 9.05e-05 | 67 |
GO:000925914 | Breast | IDC | ribonucleotide metabolic process | 56/1434 | 385/18723 | 2.47e-06 | 9.63e-05 | 56 |
GO:000616314 | Breast | IDC | purine nucleotide metabolic process | 56/1434 | 396/18723 | 5.90e-06 | 1.90e-04 | 56 |
GO:007252114 | Breast | IDC | purine-containing compound metabolic process | 57/1434 | 416/18723 | 1.28e-05 | 3.31e-04 | 57 |
GO:190136112 | Breast | IDC | organic cyclic compound catabolic process | 56/1434 | 495/18723 | 2.12e-03 | 1.99e-02 | 56 |
GO:004670012 | Breast | IDC | heterocycle catabolic process | 51/1434 | 445/18723 | 2.51e-03 | 2.25e-02 | 51 |
GO:003465513 | Breast | IDC | nucleobase-containing compound catabolic process | 47/1434 | 407/18723 | 3.12e-03 | 2.63e-02 | 47 |
GO:004427012 | Breast | IDC | cellular nitrogen compound catabolic process | 50/1434 | 451/18723 | 5.29e-03 | 3.93e-02 | 50 |
GO:001943912 | Breast | IDC | aromatic compound catabolic process | 51/1434 | 467/18723 | 6.54e-03 | 4.59e-02 | 51 |
GO:001969324 | Breast | DCIS | ribose phosphate metabolic process | 58/1390 | 396/18723 | 4.80e-07 | 2.11e-05 | 58 |
GO:000915024 | Breast | DCIS | purine ribonucleotide metabolic process | 55/1390 | 368/18723 | 4.92e-07 | 2.14e-05 | 55 |
GO:000925924 | Breast | DCIS | ribonucleotide metabolic process | 56/1390 | 385/18723 | 9.44e-07 | 3.79e-05 | 56 |
GO:000616324 | Breast | DCIS | purine nucleotide metabolic process | 56/1390 | 396/18723 | 2.31e-06 | 8.29e-05 | 56 |
GO:000911723 | Breast | DCIS | nucleotide metabolic process | 65/1390 | 489/18723 | 3.19e-06 | 1.03e-04 | 65 |
GO:007252124 | Breast | DCIS | purine-containing compound metabolic process | 57/1390 | 416/18723 | 5.07e-06 | 1.48e-04 | 57 |
GO:000675323 | Breast | DCIS | nucleoside phosphate metabolic process | 65/1390 | 497/18723 | 5.51e-06 | 1.59e-04 | 65 |
GO:003465522 | Breast | DCIS | nucleobase-containing compound catabolic process | 47/1390 | 407/18723 | 1.69e-03 | 1.68e-02 | 47 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUDT8 | SNV | Missense_Mutation | novel | c.514N>A | p.Leu172Met | p.L172M | Q8WV74 | protein_coding | deleterious(0.02) | probably_damaging(0.928) | TCGA-CN-4735-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | vectibix | SD |
NUDT8 | SNV | Missense_Mutation | novel | c.199N>A | p.Pro67Thr | p.P67T | Q8WV74 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-G9-6351-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
NUDT8 | SNV | Missense_Mutation | novel | c.382N>C | p.Ser128Arg | p.S128R | Q8WV74 | protein_coding | tolerated(0.14) | benign(0.147) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NUDT8 | SNV | Missense_Mutation | c.559N>C | p.Glu187Gln | p.E187Q | Q8WV74 | protein_coding | deleterious(0.03) | possibly_damaging(0.696) | TCGA-EM-A22M-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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