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Gene: NUDT1 |
Gene summary for NUDT1 |
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Gene information | Species | Human | Gene symbol | NUDT1 | Gene ID | 4521 |
Gene name | nudix hydrolase 1 | |
Gene Alias | MTH1 | |
Cytomap | 7p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R819 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4521 | NUDT1 | GSM4909282 | Human | Breast | IDC | 1.33e-06 | 3.57e-01 | -0.0288 |
4521 | NUDT1 | GSM4909311 | Human | Breast | IDC | 3.50e-06 | -9.78e-02 | 0.1534 |
4521 | NUDT1 | GSM4909312 | Human | Breast | IDC | 3.60e-03 | -5.51e-02 | 0.1552 |
4521 | NUDT1 | GSM4909315 | Human | Breast | IDC | 5.65e-17 | 5.94e-01 | 0.21 |
4521 | NUDT1 | GSM4909316 | Human | Breast | IDC | 4.15e-05 | 5.02e-01 | 0.21 |
4521 | NUDT1 | GSM4909319 | Human | Breast | IDC | 3.29e-18 | 7.71e-02 | 0.1563 |
4521 | NUDT1 | GSM4909321 | Human | Breast | IDC | 1.91e-04 | 7.76e-02 | 0.1559 |
4521 | NUDT1 | NCCBC3 | Human | Breast | DCIS | 1.22e-02 | 7.81e-02 | 0.1198 |
4521 | NUDT1 | NCCBC5 | Human | Breast | DCIS | 2.29e-02 | 1.92e-01 | 0.2046 |
4521 | NUDT1 | P1 | Human | Breast | IDC | 3.22e-04 | -4.50e-02 | 0.1527 |
4521 | NUDT1 | DCIS2 | Human | Breast | DCIS | 1.05e-19 | 4.37e-02 | 0.0085 |
4521 | NUDT1 | LZE2D | Human | Esophagus | HGIN | 1.97e-04 | 4.91e-01 | 0.0642 |
4521 | NUDT1 | LZE2T | Human | Esophagus | ESCC | 6.36e-05 | 1.02e+00 | 0.082 |
4521 | NUDT1 | LZE4T | Human | Esophagus | ESCC | 1.12e-11 | 4.20e-01 | 0.0811 |
4521 | NUDT1 | LZE7T | Human | Esophagus | ESCC | 2.77e-15 | 8.12e-01 | 0.0667 |
4521 | NUDT1 | LZE8T | Human | Esophagus | ESCC | 6.49e-04 | 3.60e-01 | 0.067 |
4521 | NUDT1 | LZE20T | Human | Esophagus | ESCC | 9.98e-06 | 3.73e-01 | 0.0662 |
4521 | NUDT1 | LZE22D1 | Human | Esophagus | HGIN | 1.64e-03 | 2.63e-01 | 0.0595 |
4521 | NUDT1 | LZE22T | Human | Esophagus | ESCC | 5.73e-11 | 1.07e+00 | 0.068 |
4521 | NUDT1 | LZE24T | Human | Esophagus | ESCC | 1.02e-13 | 5.37e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697914 | Breast | IDC | response to oxidative stress | 83/1434 | 446/18723 | 2.36e-14 | 7.06e-12 | 83 |
GO:001003814 | Breast | IDC | response to metal ion | 65/1434 | 373/18723 | 2.95e-10 | 3.42e-08 | 65 |
GO:004668613 | Breast | IDC | response to cadmium ion | 19/1434 | 68/18723 | 4.97e-07 | 2.45e-05 | 19 |
GO:000756813 | Breast | IDC | aging | 52/1434 | 339/18723 | 1.14e-06 | 5.10e-05 | 52 |
GO:004860812 | Breast | IDC | reproductive structure development | 60/1434 | 424/18723 | 2.71e-06 | 1.03e-04 | 60 |
GO:006145813 | Breast | IDC | reproductive system development | 60/1434 | 427/18723 | 3.41e-06 | 1.24e-04 | 60 |
GO:007252114 | Breast | IDC | purine-containing compound metabolic process | 57/1434 | 416/18723 | 1.28e-05 | 3.31e-04 | 57 |
GO:007149614 | Breast | IDC | cellular response to external stimulus | 45/1434 | 320/18723 | 5.40e-05 | 1.15e-03 | 45 |
GO:003166814 | Breast | IDC | cellular response to extracellular stimulus | 35/1434 | 246/18723 | 2.79e-04 | 4.26e-03 | 35 |
GO:0008406 | Breast | IDC | gonad development | 32/1434 | 221/18723 | 3.64e-04 | 5.23e-03 | 32 |
GO:0045137 | Breast | IDC | development of primary sexual characteristics | 32/1434 | 227/18723 | 5.85e-04 | 7.44e-03 | 32 |
GO:200102013 | Breast | IDC | regulation of response to DNA damage stimulus | 30/1434 | 219/18723 | 1.36e-03 | 1.40e-02 | 30 |
GO:190136112 | Breast | IDC | organic cyclic compound catabolic process | 56/1434 | 495/18723 | 2.12e-03 | 1.99e-02 | 56 |
GO:0007548 | Breast | IDC | sex differentiation | 35/1434 | 276/18723 | 2.23e-03 | 2.07e-02 | 35 |
GO:00085841 | Breast | IDC | male gonad development | 21/1434 | 141/18723 | 2.46e-03 | 2.22e-02 | 21 |
GO:004670012 | Breast | IDC | heterocycle catabolic process | 51/1434 | 445/18723 | 2.51e-03 | 2.25e-02 | 51 |
GO:00465461 | Breast | IDC | development of primary male sexual characteristics | 21/1434 | 142/18723 | 2.69e-03 | 2.39e-02 | 21 |
GO:003465513 | Breast | IDC | nucleobase-containing compound catabolic process | 47/1434 | 407/18723 | 3.12e-03 | 2.63e-02 | 47 |
GO:00466611 | Breast | IDC | male sex differentiation | 23/1434 | 165/18723 | 3.74e-03 | 3.07e-02 | 23 |
GO:004427012 | Breast | IDC | cellular nitrogen compound catabolic process | 50/1434 | 451/18723 | 5.29e-03 | 3.93e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUDT1 | SNV | Missense_Mutation | c.271G>A | p.Gly91Ser | p.G91S | P36639 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-55-7283-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PR | |
NUDT1 | SNV | Missense_Mutation | rs200613809 | c.143G>A | p.Arg48Gln | p.R48Q | P36639 | protein_coding | deleterious(0.04) | probably_damaging(0.942) | TCGA-86-8056-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NUDT1 | SNV | Missense_Mutation | rs746490760 | c.533N>T | p.Thr178Met | p.T178M | P36639 | protein_coding | tolerated(0.08) | benign(0.188) | TCGA-39-5016-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NUDT1 | SNV | Missense_Mutation | c.74N>C | p.Gly25Ala | p.G25A | P36639 | protein_coding | tolerated(0.53) | benign(0) | TCGA-46-3769-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
NUDT1 | SNV | Missense_Mutation | rs139296148 | c.76G>A | p.Ala26Thr | p.A26T | P36639 | protein_coding | tolerated(1) | benign(0) | TCGA-58-8391-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
NUDT1 | SNV | Missense_Mutation | rs746490760 | c.533N>T | p.Thr178Met | p.T178M | P36639 | protein_coding | tolerated(0.08) | benign(0.188) | TCGA-BA-6872-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | PD | |
NUDT1 | SNV | Missense_Mutation | c.459N>C | p.Lys153Asn | p.K153N | P36639 | protein_coding | tolerated(0.22) | benign(0.057) | TCGA-CN-A6V1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Immunotherapy | erbitux | CR | |
NUDT1 | SNV | Missense_Mutation | novel | c.404C>T | p.Pro135Leu | p.P135L | P36639 | protein_coding | deleterious(0.02) | possibly_damaging(0.847) | TCGA-D6-8568-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NUDT1 | SNV | Missense_Mutation | c.320A>G | p.His107Arg | p.H107R | P36639 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NUDT1 | insertion | Frame_Shift_Ins | novel | c.140dupA | p.Arg48AlafsTer26 | p.R48Afs*26 | P36639 | protein_coding | TCGA-VQ-A91K-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4521 | NUDT1 | DNA REPAIR, ENZYME | 8-oxo-dgtp | 26238318 |
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