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Gene: NUAK2 |
Gene summary for NUAK2 |
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Gene information | Species | Human | Gene symbol | NUAK2 | Gene ID | 81788 |
Gene name | NUAK family kinase 2 | |
Gene Alias | ANPH2 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B4E0Y5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81788 | NUAK2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.14e-07 | 2.39e-01 | -0.1954 |
81788 | NUAK2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.73e-08 | 3.75e-01 | -0.059 |
81788 | NUAK2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.61e-04 | 3.31e-01 | -0.0842 |
81788 | NUAK2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.76e-08 | 3.23e-01 | 0.096 |
81788 | NUAK2 | LZE4T | Human | Esophagus | ESCC | 6.92e-10 | 4.40e-01 | 0.0811 |
81788 | NUAK2 | LZE20T | Human | Esophagus | ESCC | 2.06e-08 | 3.64e-01 | 0.0662 |
81788 | NUAK2 | LZE22T | Human | Esophagus | ESCC | 1.01e-03 | 4.64e-01 | 0.068 |
81788 | NUAK2 | LZE21T | Human | Esophagus | ESCC | 5.75e-05 | 3.18e-01 | 0.0655 |
81788 | NUAK2 | P1T-E | Human | Esophagus | ESCC | 1.65e-19 | 9.96e-01 | 0.0875 |
81788 | NUAK2 | P2T-E | Human | Esophagus | ESCC | 5.75e-13 | 3.39e-01 | 0.1177 |
81788 | NUAK2 | P4T-E | Human | Esophagus | ESCC | 8.21e-20 | 5.29e-01 | 0.1323 |
81788 | NUAK2 | P5T-E | Human | Esophagus | ESCC | 2.41e-34 | 8.13e-01 | 0.1327 |
81788 | NUAK2 | P8T-E | Human | Esophagus | ESCC | 4.40e-10 | 2.37e-01 | 0.0889 |
81788 | NUAK2 | P9T-E | Human | Esophagus | ESCC | 6.69e-05 | 1.76e-01 | 0.1131 |
81788 | NUAK2 | P10T-E | Human | Esophagus | ESCC | 7.96e-03 | 6.94e-02 | 0.116 |
81788 | NUAK2 | P11T-E | Human | Esophagus | ESCC | 1.98e-18 | 8.58e-01 | 0.1426 |
81788 | NUAK2 | P12T-E | Human | Esophagus | ESCC | 2.74e-11 | 1.95e-01 | 0.1122 |
81788 | NUAK2 | P15T-E | Human | Esophagus | ESCC | 3.87e-09 | 2.69e-01 | 0.1149 |
81788 | NUAK2 | P16T-E | Human | Esophagus | ESCC | 1.21e-07 | 1.55e-01 | 0.1153 |
81788 | NUAK2 | P21T-E | Human | Esophagus | ESCC | 9.02e-16 | 3.28e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0042594 | Colorectum | AD | response to starvation | 63/3918 | 197/18723 | 1.77e-04 | 2.38e-03 | 63 |
GO:0071496 | Colorectum | AD | cellular response to external stimulus | 94/3918 | 320/18723 | 1.98e-04 | 2.64e-03 | 94 |
GO:0009267 | Colorectum | AD | cellular response to starvation | 51/3918 | 156/18723 | 3.90e-04 | 4.44e-03 | 51 |
GO:0031668 | Colorectum | AD | cellular response to extracellular stimulus | 71/3918 | 246/18723 | 1.86e-03 | 1.52e-02 | 71 |
GO:0031669 | Colorectum | AD | cellular response to nutrient levels | 63/3918 | 215/18723 | 2.19e-03 | 1.73e-02 | 63 |
GO:0071496111 | Esophagus | ESCC | cellular response to external stimulus | 215/8552 | 320/18723 | 4.29e-15 | 2.43e-13 | 215 |
GO:0031668111 | Esophagus | ESCC | cellular response to extracellular stimulus | 168/8552 | 246/18723 | 4.93e-13 | 2.23e-11 | 168 |
GO:0031669110 | Esophagus | ESCC | cellular response to nutrient levels | 148/8552 | 215/18723 | 4.58e-12 | 1.76e-10 | 148 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:0009267110 | Esophagus | ESCC | cellular response to starvation | 110/8552 | 156/18723 | 2.63e-10 | 7.37e-09 | 110 |
GO:004259419 | Esophagus | ESCC | response to starvation | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:00421492 | Esophagus | ESCC | cellular response to glucose starvation | 36/8552 | 48/18723 | 3.43e-05 | 2.80e-04 | 36 |
GO:007149620 | Oral cavity | OSCC | cellular response to external stimulus | 186/7305 | 320/18723 | 2.56e-12 | 1.05e-10 | 186 |
GO:003166819 | Oral cavity | OSCC | cellular response to extracellular stimulus | 141/7305 | 246/18723 | 3.99e-09 | 8.95e-08 | 141 |
GO:003166720 | Oral cavity | OSCC | response to nutrient levels | 245/7305 | 474/18723 | 1.02e-08 | 2.10e-07 | 245 |
GO:003166918 | Oral cavity | OSCC | cellular response to nutrient levels | 121/7305 | 215/18723 | 1.96e-07 | 3.17e-06 | 121 |
GO:004259416 | Oral cavity | OSCC | response to starvation | 111/7305 | 197/18723 | 5.68e-07 | 8.19e-06 | 111 |
GO:000926717 | Oral cavity | OSCC | cellular response to starvation | 91/7305 | 156/18723 | 7.55e-07 | 1.06e-05 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUAK2 | deletion | Frame_Shift_Del | novel | c.1111delT | p.Ser371LeufsTer153 | p.S371Lfs*153 | Q9H093 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
NUAK2 | deletion | In_Frame_Del | novel | c.1107_1109delTGA | p.Asp370del | p.D370del | Q9H093 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
NUAK2 | SNV | Missense_Mutation | rs561905076 | c.1837N>T | p.Arg613Trp | p.R613W | Q9H093 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUAK2 | SNV | Missense_Mutation | c.407N>G | p.Gln136Arg | p.Q136R | Q9H093 | protein_coding | deleterious(0.05) | probably_damaging(0.984) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NUAK2 | SNV | Missense_Mutation | rs558886995 | c.581N>A | p.Arg194His | p.R194H | Q9H093 | protein_coding | deleterious(0.05) | benign(0.027) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUAK2 | SNV | Missense_Mutation | novel | c.599N>C | p.Phe200Ser | p.F200S | Q9H093 | protein_coding | deleterious(0.01) | possibly_damaging(0.765) | TCGA-CK-4947-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Other, specify in notes | folinic | SD |
NUAK2 | deletion | Frame_Shift_Del | c.507_510delNNNN | p.Val170SerfsTer132 | p.V170Sfs*132 | Q9H093 | protein_coding | TCGA-AG-3731-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PR | |||
NUAK2 | SNV | Missense_Mutation | novel | c.1471N>A | p.Gly491Ser | p.G491S | Q9H093 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUAK2 | SNV | Missense_Mutation | novel | c.1652N>C | p.Lys551Thr | p.K551T | Q9H093 | protein_coding | deleterious(0) | possibly_damaging(0.78) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NUAK2 | SNV | Missense_Mutation | novel | c.658N>A | p.Leu220Ile | p.L220I | Q9H093 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
81788 | NUAK2 | KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 249565727 |
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