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Gene: NPAS3 |
Gene summary for NPAS3 |
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Gene information | Species | Human | Gene symbol | NPAS3 | Gene ID | 64067 |
Gene name | neuronal PAS domain protein 3 | |
Gene Alias | MOP6 | |
Cytomap | 14q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8IXF0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64067 | NPAS3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.43e-12 | 1.66e-01 | 0.0155 |
64067 | NPAS3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.41e-05 | 1.44e-01 | -0.1808 |
64067 | NPAS3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.79e-07 | 1.74e-01 | -0.0811 |
64067 | NPAS3 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.23e-07 | 1.76e-01 | -0.1088 |
64067 | NPAS3 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.94e-04 | 1.42e-01 | -0.1954 |
64067 | NPAS3 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.95e-07 | 1.89e-01 | -0.1464 |
64067 | NPAS3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.51e-03 | 1.27e-01 | -0.059 |
64067 | NPAS3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.38e-02 | 1.59e-01 | -0.1706 |
64067 | NPAS3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.99e-03 | 2.56e-01 | -0.1462 |
64067 | NPAS3 | HTA11_546_2000001011 | Human | Colorectum | AD | 5.84e-06 | 1.95e-01 | -0.0842 |
64067 | NPAS3 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.00e-04 | 5.05e-02 | 0.096 |
64067 | NPAS3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.22e-04 | 1.62e-01 | 0.294 |
64067 | NPAS3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.87e-05 | 5.52e-01 | 0.3487 |
64067 | NPAS3 | AEH-subject1 | Human | Endometrium | AEH | 1.59e-53 | 1.12e+00 | -0.3059 |
64067 | NPAS3 | AEH-subject2 | Human | Endometrium | AEH | 8.73e-19 | 8.25e-01 | -0.2525 |
64067 | NPAS3 | AEH-subject3 | Human | Endometrium | AEH | 1.17e-116 | 1.80e+00 | -0.2576 |
64067 | NPAS3 | AEH-subject4 | Human | Endometrium | AEH | 4.81e-26 | 1.10e+00 | -0.2657 |
64067 | NPAS3 | AEH-subject5 | Human | Endometrium | AEH | 6.35e-76 | 1.46e+00 | -0.2953 |
64067 | NPAS3 | EEC-subject1 | Human | Endometrium | EEC | 6.36e-88 | 1.48e+00 | -0.2682 |
64067 | NPAS3 | EEC-subject2 | Human | Endometrium | EEC | 2.76e-56 | 1.17e+00 | -0.2607 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPAS3 | insertion | Nonsense_Mutation | novel | c.799_800insAAAACATTTAAAAAT | p.Met267delinsLysAsnIleTerLysLeu | p.M267delinsKNI*KL | Q8IXF0 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
NPAS3 | insertion | Frame_Shift_Ins | novel | c.1007_1008insCCATA | p.Val337HisfsTer3 | p.V337Hfs*3 | Q8IXF0 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
NPAS3 | insertion | Frame_Shift_Ins | novel | c.1009_1010insAATGCTGCCTTGAGGAACGCCTGGAATGTAATAATAC | p.Val337GlufsTer23 | p.V337Efs*23 | Q8IXF0 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
NPAS3 | SNV | Missense_Mutation | rs745486995 | c.1922N>G | p.Asn641Ser | p.N641S | Q8IXF0 | protein_coding | tolerated_low_confidence(0.34) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NPAS3 | SNV | Missense_Mutation | c.437T>G | p.Phe146Cys | p.F146C | Q8IXF0 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NPAS3 | SNV | Missense_Mutation | c.2164N>A | p.Asp722Asn | p.D722N | Q8IXF0 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NPAS3 | SNV | Missense_Mutation | novel | c.1033N>G | p.Tyr345Asp | p.Y345D | Q8IXF0 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-VS-A9UM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NPAS3 | SNV | Missense_Mutation | rs763025424 | c.1858G>A | p.Ala620Thr | p.A620T | Q8IXF0 | protein_coding | tolerated_low_confidence(0.55) | benign(0) | TCGA-5M-AAT4-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
NPAS3 | SNV | Missense_Mutation | rs758344166 | c.1549N>A | p.Gly517Ser | p.G517S | Q8IXF0 | protein_coding | tolerated(0.28) | benign(0.313) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
NPAS3 | SNV | Missense_Mutation | rs777443078 | c.350G>A | p.Arg117Gln | p.R117Q | Q8IXF0 | protein_coding | deleterious(0.03) | possibly_damaging(0.538) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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