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Gene: NOSTRIN |
Gene summary for NOSTRIN |
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Gene information | Species | Human | Gene symbol | NOSTRIN | Gene ID | 115677 |
Gene name | nitric oxide synthase trafficking | |
Gene Alias | DaIP2 | |
Cytomap | 2q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8IVI9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115677 | NOSTRIN | GSM4909308 | Human | Breast | IDC | 1.20e-03 | 1.59e-01 | 0.158 |
115677 | NOSTRIN | GSM4909315 | Human | Breast | IDC | 1.78e-08 | 2.84e-01 | 0.21 |
115677 | NOSTRIN | M5 | Human | Breast | IDC | 3.86e-18 | 9.47e-01 | 0.1598 |
115677 | NOSTRIN | P3 | Human | Breast | IDC | 1.32e-05 | 4.39e-01 | 0.1542 |
115677 | NOSTRIN | DCIS2 | Human | Breast | DCIS | 4.86e-02 | -1.19e-02 | 0.0085 |
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Tissue | Expression Dynamics | Abbreviation |
Breast | ![]() | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ | ||
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOSTRIN | deletion | Frame_Shift_Del | c.572delA | p.Asn191ThrfsTer9 | p.N191Tfs*9 | Q8IVI9 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
NOSTRIN | deletion | Frame_Shift_Del | novel | c.1553delA | p.Lys518ArgfsTer5 | p.K518Rfs*5 | Q8IVI9 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NOSTRIN | insertion | Frame_Shift_Ins | novel | c.565_566insA | p.Asn191LysfsTer42 | p.N191Kfs*42 | Q8IVI9 | protein_coding | TCGA-CA-6716-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | CR | ||
NOSTRIN | SNV | Missense_Mutation | novel | c.1059N>T | p.Glu353Asp | p.E353D | Q8IVI9 | protein_coding | tolerated(0.37) | benign(0.065) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOSTRIN | SNV | Missense_Mutation | rs780279739 | c.541N>A | p.Glu181Lys | p.E181K | Q8IVI9 | protein_coding | tolerated(0.48) | benign(0.05) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NOSTRIN | SNV | Missense_Mutation | novel | c.730C>A | p.Leu244Ile | p.L244I | Q8IVI9 | protein_coding | tolerated_low_confidence(0.58) | benign(0.041) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOSTRIN | SNV | Missense_Mutation | novel | c.1163C>T | p.Ser388Phe | p.S388F | Q8IVI9 | protein_coding | deleterious(0.01) | benign(0.445) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOSTRIN | SNV | Missense_Mutation | novel | c.1678G>T | p.Ala560Ser | p.A560S | Q8IVI9 | protein_coding | tolerated_low_confidence(0.36) | benign(0.018) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOSTRIN | SNV | Missense_Mutation | novel | c.183N>T | p.Gln61His | p.Q61H | Q8IVI9 | protein_coding | deleterious(0.02) | probably_damaging(0.971) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOSTRIN | SNV | Missense_Mutation | rs746763481 | c.827N>T | p.Arg276Ile | p.R276I | Q8IVI9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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