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Gene: NOP58 |
Gene summary for NOP58 |
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Gene information | Species | Human | Gene symbol | NOP58 | Gene ID | 51602 |
Gene name | NOP58 ribonucleoprotein | |
Gene Alias | HSPC120 | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9Y2X3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51602 | NOP58 | LZE2D | Human | Esophagus | HGIN | 2.33e-04 | -2.45e-01 | 0.0642 |
51602 | NOP58 | LZE3D | Human | Esophagus | HGIN | 1.16e-05 | 5.41e-02 | 0.0668 |
51602 | NOP58 | LZE4T | Human | Esophagus | ESCC | 1.22e-05 | 5.69e-01 | 0.0811 |
51602 | NOP58 | LZE7T | Human | Esophagus | ESCC | 1.47e-05 | 6.51e-01 | 0.0667 |
51602 | NOP58 | LZE8T | Human | Esophagus | ESCC | 1.40e-05 | -1.90e-01 | 0.067 |
51602 | NOP58 | LZE21D1 | Human | Esophagus | HGIN | 1.00e-04 | -2.94e-01 | 0.0632 |
51602 | NOP58 | LZE22D1 | Human | Esophagus | HGIN | 1.59e-09 | -3.32e-01 | 0.0595 |
51602 | NOP58 | LZE22T | Human | Esophagus | ESCC | 5.72e-07 | 2.88e-01 | 0.068 |
51602 | NOP58 | LZE24T | Human | Esophagus | ESCC | 4.95e-04 | 2.53e-01 | 0.0596 |
51602 | NOP58 | LZE22D3 | Human | Esophagus | HGIN | 4.94e-02 | -2.61e-01 | 0.0653 |
51602 | NOP58 | LZE6T | Human | Esophagus | ESCC | 2.15e-05 | -3.29e-02 | 0.0845 |
51602 | NOP58 | P1T-E | Human | Esophagus | ESCC | 8.57e-05 | 5.70e-01 | 0.0875 |
51602 | NOP58 | P2T-E | Human | Esophagus | ESCC | 7.17e-30 | 8.11e-01 | 0.1177 |
51602 | NOP58 | P4T-E | Human | Esophagus | ESCC | 7.78e-40 | 1.60e+00 | 0.1323 |
51602 | NOP58 | P5T-E | Human | Esophagus | ESCC | 1.50e-48 | 1.35e+00 | 0.1327 |
51602 | NOP58 | P8T-E | Human | Esophagus | ESCC | 4.18e-14 | 3.72e-01 | 0.0889 |
51602 | NOP58 | P9T-E | Human | Esophagus | ESCC | 4.03e-11 | 5.65e-01 | 0.1131 |
51602 | NOP58 | P10T-E | Human | Esophagus | ESCC | 1.30e-25 | 5.98e-01 | 0.116 |
51602 | NOP58 | P11T-E | Human | Esophagus | ESCC | 1.55e-10 | 1.01e+00 | 0.1426 |
51602 | NOP58 | P12T-E | Human | Esophagus | ESCC | 1.61e-45 | 1.20e+00 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
GO:000640320 | Esophagus | HGIN | RNA localization | 66/2587 | 201/18723 | 4.06e-12 | 5.41e-10 | 66 |
GO:001607219 | Esophagus | HGIN | rRNA metabolic process | 72/2587 | 236/18723 | 2.26e-11 | 2.56e-09 | 72 |
GO:000636419 | Esophagus | HGIN | rRNA processing | 69/2587 | 225/18723 | 4.53e-11 | 5.04e-09 | 69 |
GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:00226137 | Liver | NAFLD | ribonucleoprotein complex biogenesis | 76/1882 | 463/18723 | 1.19e-05 | 3.67e-04 | 76 |
GO:00422547 | Liver | NAFLD | ribosome biogenesis | 52/1882 | 299/18723 | 6.03e-05 | 1.32e-03 | 52 |
GO:00344704 | Liver | NAFLD | ncRNA processing | 57/1882 | 395/18723 | 3.34e-03 | 2.93e-02 | 57 |
GO:00064037 | Liver | NAFLD | RNA localization | 32/1882 | 201/18723 | 5.96e-03 | 4.48e-02 | 32 |
GO:00063644 | Liver | NAFLD | rRNA processing | 35/1882 | 225/18723 | 6.04e-03 | 4.54e-02 | 35 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOP58 | SNV | Missense_Mutation | c.200N>C | p.Lys67Thr | p.K67T | Q9Y2X3 | protein_coding | deleterious(0.03) | benign(0.074) | TCGA-AF-A56K-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
NOP58 | insertion | Frame_Shift_Ins | rs769985110 | c.1563_1564insA | p.Arg525GlufsTer35 | p.R525Efs*35 | Q9Y2X3 | protein_coding | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | ||
NOP58 | SNV | Missense_Mutation | novel | c.311N>C | p.Leu104Pro | p.L104P | Q9Y2X3 | protein_coding | deleterious(0) | possibly_damaging(0.702) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NOP58 | SNV | Missense_Mutation | rs34523815 | c.1522N>G | p.Thr508Ala | p.T508A | Q9Y2X3 | protein_coding | tolerated(0.49) | benign(0.007) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOP58 | SNV | Missense_Mutation | novel | c.590N>A | p.Ile197Asn | p.I197N | Q9Y2X3 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOP58 | SNV | Missense_Mutation | c.1111N>T | p.Arg371Cys | p.R371C | Q9Y2X3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOP58 | SNV | Missense_Mutation | c.446N>C | p.Tyr149Ser | p.Y149S | Q9Y2X3 | protein_coding | deleterious(0) | benign(0.038) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NOP58 | SNV | Missense_Mutation | novel | c.60N>T | p.Lys20Asn | p.K20N | Q9Y2X3 | protein_coding | tolerated(0.27) | benign(0.055) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOP58 | SNV | Missense_Mutation | c.1025A>G | p.Tyr342Cys | p.Y342C | Q9Y2X3 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
NOP58 | SNV | Missense_Mutation | rs759580885 | c.1327C>T | p.Arg443Cys | p.R443C | Q9Y2X3 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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