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Gene: NOL12 |
Gene summary for NOL12 |
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Gene information | Species | Human | Gene symbol | NOL12 | Gene ID | 79159 |
Gene name | nucleolar protein 12 | |
Gene Alias | Nop25 | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R1M6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79159 | NOL12 | LZE4T | Human | Esophagus | ESCC | 5.47e-11 | 2.73e-01 | 0.0811 |
79159 | NOL12 | LZE5T | Human | Esophagus | ESCC | 2.43e-03 | 2.83e-01 | 0.0514 |
79159 | NOL12 | LZE7T | Human | Esophagus | ESCC | 9.18e-12 | 4.66e-01 | 0.0667 |
79159 | NOL12 | LZE8T | Human | Esophagus | ESCC | 1.24e-06 | 2.08e-01 | 0.067 |
79159 | NOL12 | LZE20T | Human | Esophagus | ESCC | 1.46e-08 | 2.25e-01 | 0.0662 |
79159 | NOL12 | LZE22T | Human | Esophagus | ESCC | 2.36e-02 | 2.55e-01 | 0.068 |
79159 | NOL12 | LZE24T | Human | Esophagus | ESCC | 3.25e-19 | 3.89e-01 | 0.0596 |
79159 | NOL12 | LZE21T | Human | Esophagus | ESCC | 2.16e-09 | 5.22e-01 | 0.0655 |
79159 | NOL12 | LZE6T | Human | Esophagus | ESCC | 5.18e-09 | 3.29e-01 | 0.0845 |
79159 | NOL12 | P1T-E | Human | Esophagus | ESCC | 1.26e-13 | 6.02e-01 | 0.0875 |
79159 | NOL12 | P2T-E | Human | Esophagus | ESCC | 2.74e-23 | 4.51e-01 | 0.1177 |
79159 | NOL12 | P4T-E | Human | Esophagus | ESCC | 3.34e-20 | 4.39e-01 | 0.1323 |
79159 | NOL12 | P5T-E | Human | Esophagus | ESCC | 6.18e-19 | 4.23e-01 | 0.1327 |
79159 | NOL12 | P8T-E | Human | Esophagus | ESCC | 8.78e-20 | 3.77e-01 | 0.0889 |
79159 | NOL12 | P9T-E | Human | Esophagus | ESCC | 1.86e-17 | 3.54e-01 | 0.1131 |
79159 | NOL12 | P10T-E | Human | Esophagus | ESCC | 1.01e-33 | 5.50e-01 | 0.116 |
79159 | NOL12 | P11T-E | Human | Esophagus | ESCC | 3.53e-13 | 4.15e-01 | 0.1426 |
79159 | NOL12 | P12T-E | Human | Esophagus | ESCC | 4.63e-19 | 3.21e-01 | 0.1122 |
79159 | NOL12 | P15T-E | Human | Esophagus | ESCC | 3.03e-21 | 4.51e-01 | 0.1149 |
79159 | NOL12 | P16T-E | Human | Esophagus | ESCC | 5.53e-28 | 5.28e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOL12 | SNV | Missense_Mutation | novel | c.505N>A | p.His169Asn | p.H169N | Q9UGY1 | protein_coding | tolerated(0.07) | possibly_damaging(0.758) | TCGA-AJ-A2QL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
NOL12 | SNV | Missense_Mutation | c.21G>T | p.Lys7Asn | p.K7N | Q9UGY1 | protein_coding | deleterious(0.01) | possibly_damaging(0.66) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
NOL12 | SNV | Missense_Mutation | rs371438425 | c.548G>A | p.Arg183Gln | p.R183Q | Q9UGY1 | protein_coding | tolerated(0.36) | benign(0.001) | TCGA-BS-A0TJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOL12 | SNV | Missense_Mutation | c.413N>T | p.Ala138Val | p.A138V | Q9UGY1 | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOL12 | SNV | Missense_Mutation | rs573370291 | c.122G>A | p.Arg41Gln | p.R41Q | Q9UGY1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOL12 | SNV | Missense_Mutation | rs767390432 | c.571C>T | p.Pro191Ser | p.P191S | Q9UGY1 | protein_coding | tolerated(0.51) | possibly_damaging(0.478) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOL12 | SNV | Missense_Mutation | c.295N>A | p.Asp99Asn | p.D99N | Q9UGY1 | protein_coding | deleterious(0) | benign(0.343) | TCGA-78-7153-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOL12 | SNV | Missense_Mutation | rs752018030 | c.364N>T | p.Gly122Trp | p.G122W | Q9UGY1 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-18-3416-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NOL12 | SNV | Missense_Mutation | novel | c.388N>T | p.Ala130Ser | p.A130S | Q9UGY1 | protein_coding | tolerated(0.49) | benign(0.015) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
NOL12 | SNV | Missense_Mutation | c.335N>G | p.Asp112Gly | p.D112G | Q9UGY1 | protein_coding | deleterious(0.01) | possibly_damaging(0.492) | TCGA-CN-6011-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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