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Gene: NKIRAS2 |
Gene summary for NKIRAS2 |
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Gene information | Species | Human | Gene symbol | NKIRAS2 | Gene ID | 28511 |
Gene name | NFKB inhibitor interacting Ras like 2 | |
Gene Alias | KBRAS2 | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A0A024R1Z4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28511 | NKIRAS2 | LZE4T | Human | Esophagus | ESCC | 1.37e-08 | 3.35e-01 | 0.0811 |
28511 | NKIRAS2 | LZE5T | Human | Esophagus | ESCC | 1.53e-03 | 2.64e-01 | 0.0514 |
28511 | NKIRAS2 | LZE7T | Human | Esophagus | ESCC | 2.98e-07 | 5.06e-01 | 0.0667 |
28511 | NKIRAS2 | LZE8T | Human | Esophagus | ESCC | 1.16e-05 | 2.25e-01 | 0.067 |
28511 | NKIRAS2 | LZE24T | Human | Esophagus | ESCC | 5.23e-21 | 6.42e-01 | 0.0596 |
28511 | NKIRAS2 | LZE6T | Human | Esophagus | ESCC | 1.21e-04 | 3.39e-01 | 0.0845 |
28511 | NKIRAS2 | P1T-E | Human | Esophagus | ESCC | 1.38e-07 | 5.28e-01 | 0.0875 |
28511 | NKIRAS2 | P2T-E | Human | Esophagus | ESCC | 2.25e-36 | 6.95e-01 | 0.1177 |
28511 | NKIRAS2 | P4T-E | Human | Esophagus | ESCC | 8.26e-30 | 7.70e-01 | 0.1323 |
28511 | NKIRAS2 | P5T-E | Human | Esophagus | ESCC | 6.21e-24 | 5.12e-01 | 0.1327 |
28511 | NKIRAS2 | P8T-E | Human | Esophagus | ESCC | 1.30e-23 | 3.61e-01 | 0.0889 |
28511 | NKIRAS2 | P9T-E | Human | Esophagus | ESCC | 1.85e-15 | 3.58e-01 | 0.1131 |
28511 | NKIRAS2 | P10T-E | Human | Esophagus | ESCC | 4.36e-21 | 4.50e-01 | 0.116 |
28511 | NKIRAS2 | P11T-E | Human | Esophagus | ESCC | 5.99e-18 | 7.06e-01 | 0.1426 |
28511 | NKIRAS2 | P12T-E | Human | Esophagus | ESCC | 6.67e-34 | 7.26e-01 | 0.1122 |
28511 | NKIRAS2 | P15T-E | Human | Esophagus | ESCC | 2.65e-23 | 5.94e-01 | 0.1149 |
28511 | NKIRAS2 | P16T-E | Human | Esophagus | ESCC | 9.34e-38 | 7.29e-01 | 0.1153 |
28511 | NKIRAS2 | P17T-E | Human | Esophagus | ESCC | 5.01e-04 | 3.30e-01 | 0.1278 |
28511 | NKIRAS2 | P19T-E | Human | Esophagus | ESCC | 9.74e-05 | 4.74e-01 | 0.1662 |
28511 | NKIRAS2 | P20T-E | Human | Esophagus | ESCC | 2.20e-22 | 4.66e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000724919 | Esophagus | ESCC | I-kappaB kinase/NF-kappaB signaling | 183/8552 | 281/18723 | 3.02e-11 | 1.01e-09 | 183 |
GO:00072494 | Liver | Cirrhotic | I-kappaB kinase/NF-kappaB signaling | 108/4634 | 281/18723 | 2.21e-07 | 5.64e-06 | 108 |
GO:000724912 | Liver | HCC | I-kappaB kinase/NF-kappaB signaling | 156/7958 | 281/18723 | 6.66e-06 | 8.00e-05 | 156 |
GO:000724910 | Oral cavity | OSCC | I-kappaB kinase/NF-kappaB signaling | 169/7305 | 281/18723 | 4.69e-13 | 2.25e-11 | 169 |
GO:000724925 | Skin | cSCC | I-kappaB kinase/NF-kappaB signaling | 116/4864 | 281/18723 | 1.33e-08 | 4.08e-07 | 116 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NKIRAS2 | SNV | Missense_Mutation | c.275A>G | p.Glu92Gly | p.E92G | Q9NYR9 | protein_coding | deleterious(0.01) | possibly_damaging(0.772) | TCGA-CC-A5UE-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
NKIRAS2 | SNV | Missense_Mutation | novel | c.182N>G | p.Asp61Gly | p.D61G | Q9NYR9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-44-7662-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NKIRAS2 | SNV | Missense_Mutation | c.133G>T | p.Gly45Cys | p.G45C | Q9NYR9 | protein_coding | tolerated(0.07) | benign(0.076) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
NKIRAS2 | SNV | Missense_Mutation | novel | c.145N>G | p.Thr49Ala | p.T49A | Q9NYR9 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-CR-7365-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD |
NKIRAS2 | SNV | Missense_Mutation | c.500A>G | p.Lys167Arg | p.K167R | Q9NYR9 | protein_coding | tolerated(0.4) | benign(0.028) | TCGA-EJ-7331-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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