![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NIPSNAP1 |
Gene summary for NIPSNAP1 |
![]() |
Gene information | Species | Human | Gene symbol | NIPSNAP1 | Gene ID | 8508 |
Gene name | nipsnap homolog 1 | |
Gene Alias | NIPSNAP1 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | B4DQI7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8508 | NIPSNAP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.73e-03 | 2.10e-01 | 0.0155 |
8508 | NIPSNAP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.50e-13 | 4.84e-01 | -0.1954 |
8508 | NIPSNAP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.44e-06 | 3.77e-01 | -0.1464 |
8508 | NIPSNAP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.42e-08 | 3.85e-01 | -0.1001 |
8508 | NIPSNAP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.51e-21 | 7.87e-01 | -0.059 |
8508 | NIPSNAP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.62e-02 | 3.72e-01 | -0.0842 |
8508 | NIPSNAP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.35e-04 | 3.05e-01 | 0.096 |
8508 | NIPSNAP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.72e-05 | 3.22e-01 | 0.0674 |
8508 | NIPSNAP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.42e-05 | 3.70e-01 | 0.294 |
8508 | NIPSNAP1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.62e-04 | 7.29e-01 | 0.3487 |
8508 | NIPSNAP1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.98e-06 | 4.05e-01 | 0.281 |
8508 | NIPSNAP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.50e-06 | 4.09e-01 | 0.3859 |
8508 | NIPSNAP1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.47e-04 | 4.91e-01 | 0.2585 |
8508 | NIPSNAP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.30e-06 | 3.08e-01 | 0.3005 |
8508 | NIPSNAP1 | A015-C-104 | Human | Colorectum | FAP | 2.43e-02 | -1.46e-01 | -0.1899 |
8508 | NIPSNAP1 | LZE2T | Human | Esophagus | ESCC | 7.35e-07 | 4.22e-01 | 0.082 |
8508 | NIPSNAP1 | LZE4T | Human | Esophagus | ESCC | 4.61e-10 | 2.70e-01 | 0.0811 |
8508 | NIPSNAP1 | LZE7T | Human | Esophagus | ESCC | 1.08e-08 | 7.65e-01 | 0.0667 |
8508 | NIPSNAP1 | LZE8T | Human | Esophagus | ESCC | 1.35e-07 | 2.54e-01 | 0.067 |
8508 | NIPSNAP1 | LZE20T | Human | Esophagus | ESCC | 4.30e-05 | 1.48e-01 | 0.0662 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NIPSNAP1 | SNV | Missense_Mutation | novel | c.217N>C | p.Lys73Gln | p.K73Q | Q9BPW8 | protein_coding | deleterious(0.05) | probably_damaging(0.916) | TCGA-NC-A5HH-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NIPSNAP1 | SNV | Missense_Mutation | novel | c.239N>T | p.Lys80Met | p.K80M | Q9BPW8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-A63U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NIPSNAP1 | SNV | Missense_Mutation | novel | c.161N>T | p.Pro54Leu | p.P54L | Q9BPW8 | protein_coding | deleterious(0) | possibly_damaging(0.703) | TCGA-CR-6487-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NIPSNAP1 | SNV | Missense_Mutation | novel | c.464N>T | p.Arg155Leu | p.R155L | Q9BPW8 | protein_coding | deleterious(0) | benign(0.119) | TCGA-BR-4187-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NIPSNAP1 | SNV | Missense_Mutation | novel | c.453C>G | p.Phe151Leu | p.F151L | Q9BPW8 | protein_coding | tolerated(0.52) | benign(0.04) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NIPSNAP1 | SNV | Missense_Mutation | novel | c.616C>T | p.Arg206Trp | p.R206W | Q9BPW8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |