![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NFAM1 |
Gene summary for NFAM1 |
![]() |
Gene information | Species | Human | Gene symbol | NFAM1 | Gene ID | 150372 |
Gene name | NFAT activating protein with ITAM motif 1 | |
Gene Alias | CNAIP | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q8NET5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
150372 | NFAM1 | HCC1 | Human | Liver | HCC | 1.11e-05 | 1.06e+00 | 0.5336 |
150372 | NFAM1 | HCC2 | Human | Liver | HCC | 1.04e-18 | 1.57e+00 | 0.5341 |
150372 | NFAM1 | HCC5 | Human | Liver | HCC | 1.18e-06 | 7.05e-01 | 0.4932 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510902 | Liver | HCC | regulation of DNA-binding transcription factor activity | 220/7958 | 440/18723 | 8.04e-04 | 4.82e-03 | 220 |
GO:00510913 | Liver | HCC | positive regulation of DNA-binding transcription factor activity | 131/7958 | 260/18723 | 5.98e-03 | 2.45e-02 | 131 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFAM1 | SNV | Missense_Mutation | c.702C>G | p.Ile234Met | p.I234M | Q8NET5 | protein_coding | tolerated(0.12) | benign(0.111) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NFAM1 | SNV | Missense_Mutation | c.272N>A | p.Arg91Lys | p.R91K | Q8NET5 | protein_coding | tolerated(0.51) | benign(0.001) | TCGA-55-7227-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | SD | |
NFAM1 | SNV | Missense_Mutation | rs778608277 | c.434N>T | p.Thr145Ile | p.T145I | Q8NET5 | protein_coding | tolerated(0.22) | benign(0.135) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
NFAM1 | SNV | Missense_Mutation | c.536N>A | p.Val179Glu | p.V179E | Q8NET5 | protein_coding | deleterious(0) | possibly_damaging(0.461) | TCGA-64-5778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | tarceva | PD | |
NFAM1 | SNV | Missense_Mutation | c.578N>A | p.Gly193Asp | p.G193D | Q8NET5 | protein_coding | deleterious(0.04) | benign(0.047) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
NFAM1 | SNV | Missense_Mutation | novel | c.422G>A | p.Arg141Lys | p.R141K | Q8NET5 | protein_coding | tolerated(1) | benign(0) | TCGA-MP-A4TI-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NFAM1 | SNV | Missense_Mutation | novel | c.509N>G | p.Thr170Ser | p.T170S | Q8NET5 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-21-1075-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NFAM1 | SNV | Missense_Mutation | c.600N>T | p.Arg200Ser | p.R200S | Q8NET5 | protein_coding | tolerated(0.14) | benign(0.055) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
NFAM1 | SNV | Missense_Mutation | novel | c.220N>A | p.Gln74Lys | p.Q74K | Q8NET5 | protein_coding | tolerated(0.88) | benign(0) | TCGA-ZG-A9NI-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
NFAM1 | SNV | Missense_Mutation | c.241A>G | p.Ser81Gly | p.S81G | Q8NET5 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |