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Gene: NEDD4 |
Gene summary for NEDD4 |
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Gene information | Species | Human | Gene symbol | NEDD4 | Gene ID | 4734 |
Gene name | NEDD4 E3 ubiquitin protein ligase | |
Gene Alias | NEDD4-1 | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P46934 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4734 | NEDD4 | CCI_1 | Human | Cervix | CC | 5.18e-05 | 1.37e+00 | 0.528 |
4734 | NEDD4 | CCI_2 | Human | Cervix | CC | 5.82e-04 | 5.82e-01 | 0.5249 |
4734 | NEDD4 | LZE4T | Human | Esophagus | ESCC | 7.88e-07 | 2.72e-01 | 0.0811 |
4734 | NEDD4 | LZE24T | Human | Esophagus | ESCC | 6.05e-03 | 5.58e-02 | 0.0596 |
4734 | NEDD4 | LZE6T | Human | Esophagus | ESCC | 4.38e-03 | 1.68e-01 | 0.0845 |
4734 | NEDD4 | P1T-E | Human | Esophagus | ESCC | 3.22e-02 | 1.68e-01 | 0.0875 |
4734 | NEDD4 | P2T-E | Human | Esophagus | ESCC | 2.31e-10 | 2.39e-01 | 0.1177 |
4734 | NEDD4 | P4T-E | Human | Esophagus | ESCC | 1.57e-10 | 2.50e-01 | 0.1323 |
4734 | NEDD4 | P5T-E | Human | Esophagus | ESCC | 4.55e-11 | 1.55e-01 | 0.1327 |
4734 | NEDD4 | P8T-E | Human | Esophagus | ESCC | 5.39e-10 | 1.52e-01 | 0.0889 |
4734 | NEDD4 | P9T-E | Human | Esophagus | ESCC | 2.15e-06 | 1.66e-01 | 0.1131 |
4734 | NEDD4 | P10T-E | Human | Esophagus | ESCC | 3.92e-07 | 1.20e-01 | 0.116 |
4734 | NEDD4 | P11T-E | Human | Esophagus | ESCC | 3.64e-03 | 2.58e-01 | 0.1426 |
4734 | NEDD4 | P12T-E | Human | Esophagus | ESCC | 4.86e-11 | 1.67e-01 | 0.1122 |
4734 | NEDD4 | P15T-E | Human | Esophagus | ESCC | 2.32e-09 | 1.95e-01 | 0.1149 |
4734 | NEDD4 | P16T-E | Human | Esophagus | ESCC | 3.00e-09 | 1.65e-01 | 0.1153 |
4734 | NEDD4 | P17T-E | Human | Esophagus | ESCC | 1.58e-02 | 1.54e-01 | 0.1278 |
4734 | NEDD4 | P19T-E | Human | Esophagus | ESCC | 1.97e-04 | 3.99e-01 | 0.1662 |
4734 | NEDD4 | P20T-E | Human | Esophagus | ESCC | 1.30e-06 | 1.72e-01 | 0.1124 |
4734 | NEDD4 | P21T-E | Human | Esophagus | ESCC | 6.46e-08 | 1.13e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:001905810 | Cervix | CC | viral life cycle | 87/2311 | 317/18723 | 2.20e-13 | 1.20e-10 | 87 |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:004573210 | Cervix | CC | positive regulation of protein catabolic process | 65/2311 | 231/18723 | 7.44e-11 | 1.39e-08 | 65 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:004361810 | Cervix | CC | regulation of transcription from RNA polymerase II promoter in response to stress | 21/2311 | 47/18723 | 3.85e-08 | 2.53e-06 | 21 |
GO:00069139 | Cervix | CC | nucleocytoplasmic transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00511699 | Cervix | CC | nuclear transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:004362010 | Cervix | CC | regulation of DNA-templated transcription in response to stress | 22/2311 | 53/18723 | 9.29e-08 | 5.19e-06 | 22 |
GO:00002097 | Cervix | CC | protein polyubiquitination | 58/2311 | 236/18723 | 1.57e-07 | 7.41e-06 | 58 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:004854510 | Cervix | CC | response to steroid hormone | 74/2311 | 339/18723 | 5.71e-07 | 2.09e-05 | 74 |
GO:00305229 | Cervix | CC | intracellular receptor signaling pathway | 60/2311 | 265/18723 | 1.89e-06 | 5.97e-05 | 60 |
GO:000660510 | Cervix | CC | protein targeting | 68/2311 | 314/18723 | 2.17e-06 | 6.55e-05 | 68 |
GO:00468229 | Cervix | CC | regulation of nucleocytoplasmic transport | 31/2311 | 106/18723 | 2.68e-06 | 7.87e-05 | 31 |
GO:00323868 | Cervix | CC | regulation of intracellular transport | 71/2311 | 337/18723 | 3.70e-06 | 9.74e-05 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0516920 | Cervix | CC | Epstein-Barr virus infection | 57/1267 | 202/8465 | 7.30e-07 | 7.39e-06 | 4.37e-06 | 57 |
hsa0453020 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa05169110 | Cervix | CC | Epstein-Barr virus infection | 57/1267 | 202/8465 | 7.30e-07 | 7.39e-06 | 4.37e-06 | 57 |
hsa04530110 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa05169210 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa04530211 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0516937 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa04530310 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa0412010 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0453014 | Liver | NAFLD | Tight junction | 33/1043 | 169/8465 | 4.52e-03 | 4.12e-02 | 3.32e-02 | 33 |
hsa0412011 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0453015 | Liver | NAFLD | Tight junction | 33/1043 | 169/8465 | 4.52e-03 | 4.12e-02 | 3.32e-02 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NEDD4 | SNV | Missense_Mutation | c.1834N>G | p.Leu612Val | p.L612V | P46934 | protein_coding | deleterious(0) | possibly_damaging(0.842) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
NEDD4 | SNV | Missense_Mutation | novel | c.1341N>A | p.Asn447Lys | p.N447K | P46934 | protein_coding | deleterious_low_confidence(0.03) | benign(0.039) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
NEDD4 | SNV | Missense_Mutation | novel | c.2917G>C | p.Glu973Gln | p.E973Q | P46934 | protein_coding | deleterious(0.01) | possibly_damaging(0.892) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NEDD4 | SNV | Missense_Mutation | c.3372N>C | p.Glu1124Asp | p.E1124D | P46934 | protein_coding | tolerated(0.18) | benign(0.051) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NEDD4 | SNV | Missense_Mutation | c.2152N>A | p.Glu718Lys | p.E718K | P46934 | protein_coding | deleterious(0.01) | benign(0.146) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NEDD4 | SNV | Missense_Mutation | novel | c.1553N>C | p.Arg518Thr | p.R518T | P46934 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
NEDD4 | SNV | Missense_Mutation | c.2392N>G | p.Pro798Ala | p.P798A | P46934 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NEDD4 | SNV | Missense_Mutation | rs781704268 | c.3827C>T | p.Thr1276Ile | p.T1276I | P46934 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-A6-4107-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5 | SD |
NEDD4 | SNV | Missense_Mutation | rs550537760 | c.2194N>A | p.Val732Met | p.V732M | P46934 | protein_coding | tolerated(0.09) | benign(0.11) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NEDD4 | SNV | Missense_Mutation | rs184505235 | c.56G>A | p.Arg19Gln | p.R19Q | P46934 | protein_coding | tolerated(0.05) | probably_damaging(0.92) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4734 | NEDD4 | ENZYME | warfarin | WARFARIN | 27488176 |
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