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Gene: NECAB1 |
Gene summary for NECAB1 |
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Gene information | Species | Human | Gene symbol | NECAB1 | Gene ID | 64168 |
Gene name | N-terminal EF-hand calcium binding protein 1 | |
Gene Alias | EFCBP1 | |
Cytomap | 8q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | Q8N987 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64168 | NECAB1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.13e-08 | 6.38e-01 | -0.2116 |
64168 | NECAB1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.53e-05 | 7.47e-01 | -0.1941 |
64168 | NECAB1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 4.56e-04 | 6.58e-01 | -0.2107 |
64168 | NECAB1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.53e-11 | 7.50e-01 | -0.2119 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000170112 | Lung | AIS | in utero embryonic development | 59/1849 | 367/18723 | 1.20e-04 | 2.75e-03 | 59 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NECAB1 | SNV | Missense_Mutation | c.207N>A | p.Phe69Leu | p.F69L | Q8N987 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NECAB1 | SNV | Missense_Mutation | c.645G>T | p.Met215Ile | p.M215I | Q8N987 | protein_coding | tolerated(0.34) | benign(0) | TCGA-AA-3866-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NECAB1 | SNV | Missense_Mutation | c.913N>C | p.Trp305Arg | p.W305R | Q8N987 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NECAB1 | SNV | Missense_Mutation | novel | c.265N>G | p.Phe89Val | p.F89V | Q8N987 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NECAB1 | SNV | Missense_Mutation | c.860N>T | p.Arg287Leu | p.R287L | Q8N987 | protein_coding | deleterious(0.03) | benign(0.096) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NECAB1 | SNV | Missense_Mutation | novel | c.787N>A | p.Glu263Lys | p.E263K | Q8N987 | protein_coding | tolerated(0.4) | probably_damaging(0.925) | TCGA-CM-6679-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NECAB1 | SNV | Missense_Mutation | novel | c.566N>T | p.Arg189Ile | p.R189I | Q8N987 | protein_coding | deleterious(0) | possibly_damaging(0.497) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NECAB1 | SNV | Missense_Mutation | novel | c.766C>T | p.Arg256Trp | p.R256W | Q8N987 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NECAB1 | SNV | Missense_Mutation | novel | c.915N>T | p.Trp305Cys | p.W305C | Q8N987 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NECAB1 | SNV | Missense_Mutation | c.590G>A | p.Ser197Asn | p.S197N | Q8N987 | protein_coding | tolerated(0.35) | benign(0) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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