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Gene: NARF |
Gene summary for NARF |
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Gene information | Species | Human | Gene symbol | NARF | Gene ID | 26502 |
Gene name | nuclear prelamin A recognition factor | |
Gene Alias | IOP2 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9UHQ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26502 | NARF | LZE4T | Human | Esophagus | ESCC | 1.61e-21 | 5.27e-01 | 0.0811 |
26502 | NARF | LZE5T | Human | Esophagus | ESCC | 1.00e-07 | 2.18e-01 | 0.0514 |
26502 | NARF | LZE7T | Human | Esophagus | ESCC | 4.01e-18 | 9.24e-01 | 0.0667 |
26502 | NARF | LZE8T | Human | Esophagus | ESCC | 9.71e-24 | 5.65e-01 | 0.067 |
26502 | NARF | LZE20T | Human | Esophagus | ESCC | 5.46e-12 | 2.44e-01 | 0.0662 |
26502 | NARF | LZE21D1 | Human | Esophagus | HGIN | 1.16e-04 | 4.26e-01 | 0.0632 |
26502 | NARF | LZE22D1 | Human | Esophagus | HGIN | 9.36e-04 | 2.76e-01 | 0.0595 |
26502 | NARF | LZE22T | Human | Esophagus | ESCC | 2.29e-08 | 9.66e-01 | 0.068 |
26502 | NARF | LZE24T | Human | Esophagus | ESCC | 1.33e-37 | 1.03e+00 | 0.0596 |
26502 | NARF | LZE22D3 | Human | Esophagus | HGIN | 1.90e-08 | 9.82e-01 | 0.0653 |
26502 | NARF | LZE21T | Human | Esophagus | ESCC | 1.35e-12 | 6.09e-01 | 0.0655 |
26502 | NARF | LZE6T | Human | Esophagus | ESCC | 4.50e-11 | 3.20e-01 | 0.0845 |
26502 | NARF | P1T-E | Human | Esophagus | ESCC | 1.19e-15 | 7.57e-01 | 0.0875 |
26502 | NARF | P2T-E | Human | Esophagus | ESCC | 1.69e-22 | 4.42e-01 | 0.1177 |
26502 | NARF | P4T-E | Human | Esophagus | ESCC | 1.81e-32 | 6.20e-01 | 0.1323 |
26502 | NARF | P5T-E | Human | Esophagus | ESCC | 1.42e-21 | 3.93e-01 | 0.1327 |
26502 | NARF | P8T-E | Human | Esophagus | ESCC | 3.14e-31 | 5.82e-01 | 0.0889 |
26502 | NARF | P9T-E | Human | Esophagus | ESCC | 2.88e-20 | 4.65e-01 | 0.1131 |
26502 | NARF | P10T-E | Human | Esophagus | ESCC | 5.44e-51 | 8.17e-01 | 0.116 |
26502 | NARF | P11T-E | Human | Esophagus | ESCC | 3.19e-33 | 1.42e+00 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NARF | SNV | Missense_Mutation | c.251N>C | p.Lys84Thr | p.K84T | Q9UHQ1 | protein_coding | deleterious(0.02) | benign(0.424) | TCGA-4N-A93T-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | SD | |
NARF | SNV | Missense_Mutation | c.414N>G | p.Ile138Met | p.I138M | Q9UHQ1 | protein_coding | deleterious(0.03) | possibly_damaging(0.734) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NARF | SNV | Missense_Mutation | novel | c.1324T>C | p.Tyr442His | p.Y442H | Q9UHQ1 | protein_coding | deleterious(0.03) | benign(0.144) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NARF | SNV | Missense_Mutation | novel | c.247N>G | p.Asn83Asp | p.N83D | Q9UHQ1 | protein_coding | deleterious(0) | benign(0.193) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NARF | SNV | Missense_Mutation | novel | c.355N>G | p.Arg119Gly | p.R119G | Q9UHQ1 | protein_coding | deleterious(0.01) | possibly_damaging(0.756) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NARF | SNV | Missense_Mutation | novel | c.76N>T | p.Asp26Tyr | p.D26Y | Q9UHQ1 | protein_coding | deleterious(0) | benign(0.187) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NARF | SNV | Missense_Mutation | c.1340G>A | p.Arg447His | p.R447H | Q9UHQ1 | protein_coding | tolerated(0.1) | benign(0) | TCGA-AF-5654-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NARF | SNV | Missense_Mutation | novel | c.214N>C | p.Asn72His | p.N72H | Q9UHQ1 | protein_coding | deleterious(0) | possibly_damaging(0.8) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NARF | deletion | Frame_Shift_Del | c.721delN | p.Pro242LeufsTer13 | p.P242Lfs*13 | Q9UHQ1 | protein_coding | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | |||
NARF | SNV | Missense_Mutation | novel | c.839N>A | p.Gly280Glu | p.G280E | Q9UHQ1 | protein_coding | tolerated(0.08) | possibly_damaging(0.492) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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