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Gene: N4BP2 |
Gene summary for N4BP2 |
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Gene information | Species | Human | Gene symbol | N4BP2 | Gene ID | 55728 |
Gene name | NEDD4 binding protein 2 | |
Gene Alias | B3BP | |
Cytomap | 4p14 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B2ZZ87 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55728 | N4BP2 | EEC-subject3 | Human | Endometrium | EEC | 6.73e-03 | -5.07e-02 | -0.2525 |
55728 | N4BP2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 5.90e-11 | -1.41e-02 | -0.1869 |
55728 | N4BP2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.21e-14 | -2.99e-02 | -0.1875 |
55728 | N4BP2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.96e-11 | -8.39e-02 | -0.1883 |
55728 | N4BP2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.93e-06 | -4.73e-02 | -0.1934 |
55728 | N4BP2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.20e-07 | -1.22e-01 | -0.1917 |
55728 | N4BP2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 3.69e-14 | -3.20e-02 | -0.1916 |
55728 | N4BP2 | NAFLD1 | Human | Liver | NAFLD | 5.33e-07 | 6.82e-01 | -0.04 |
55728 | N4BP2 | HCC1_Meng | Human | Liver | HCC | 2.78e-60 | 1.58e-01 | 0.0246 |
55728 | N4BP2 | HCC2_Meng | Human | Liver | HCC | 1.14e-10 | 6.00e-02 | 0.0107 |
55728 | N4BP2 | HCC1 | Human | Liver | HCC | 6.25e-12 | 4.20e+00 | 0.5336 |
55728 | N4BP2 | HCC2 | Human | Liver | HCC | 1.68e-22 | 3.73e+00 | 0.5341 |
55728 | N4BP2 | HCC5 | Human | Liver | HCC | 1.96e-06 | 1.79e+00 | 0.4932 |
55728 | N4BP2 | S015 | Human | Liver | HCC | 7.25e-03 | 2.81e-01 | 0.2375 |
55728 | N4BP2 | male-WTA | Human | Thyroid | PTC | 1.29e-06 | 6.71e-02 | 0.1037 |
55728 | N4BP2 | PTC01 | Human | Thyroid | PTC | 3.08e-02 | 1.10e-01 | 0.1899 |
55728 | N4BP2 | PTC04 | Human | Thyroid | PTC | 2.22e-08 | 2.28e-01 | 0.1927 |
55728 | N4BP2 | PTC05 | Human | Thyroid | PTC | 5.68e-07 | 3.55e-01 | 0.2065 |
55728 | N4BP2 | PTC06 | Human | Thyroid | PTC | 1.23e-24 | 5.37e-01 | 0.2057 |
55728 | N4BP2 | PTC07 | Human | Thyroid | PTC | 1.54e-23 | 3.53e-01 | 0.2044 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00017017 | Breast | Precancer | in utero embryonic development | 35/1080 | 367/18723 | 2.47e-03 | 2.27e-02 | 35 |
GO:000170113 | Breast | IDC | in utero embryonic development | 42/1434 | 367/18723 | 5.85e-03 | 4.24e-02 | 42 |
GO:000170122 | Breast | DCIS | in utero embryonic development | 41/1390 | 367/18723 | 5.74e-03 | 4.13e-02 | 41 |
GO:20007362 | Cervix | CC | regulation of stem cell differentiation | 19/2311 | 58/18723 | 4.01e-05 | 6.21e-04 | 19 |
GO:00488634 | Cervix | CC | stem cell differentiation | 46/2311 | 206/18723 | 4.11e-05 | 6.36e-04 | 46 |
GO:00017018 | Cervix | CC | in utero embryonic development | 71/2311 | 367/18723 | 7.21e-05 | 1.00e-03 | 71 |
GO:20007372 | Cervix | CC | negative regulation of stem cell differentiation | 10/2311 | 23/18723 | 2.00e-04 | 2.29e-03 | 10 |
GO:00022443 | Cervix | CC | hematopoietic progenitor cell differentiation | 26/2311 | 114/18723 | 1.30e-03 | 1.03e-02 | 26 |
GO:0060218 | Cervix | CC | hematopoietic stem cell differentiation | 10/2311 | 30/18723 | 2.33e-03 | 1.66e-02 | 10 |
GO:1901532 | Cervix | CC | regulation of hematopoietic progenitor cell differentiation | 10/2311 | 32/18723 | 3.96e-03 | 2.48e-02 | 10 |
GO:1902036 | Cervix | CC | regulation of hematopoietic stem cell differentiation | 6/2311 | 14/18723 | 4.36e-03 | 2.67e-02 | 6 |
GO:004886313 | Cervix | N_HPV | stem cell differentiation | 14/534 | 206/18723 | 2.43e-03 | 2.20e-02 | 14 |
GO:200073711 | Cervix | N_HPV | negative regulation of stem cell differentiation | 4/534 | 23/18723 | 3.76e-03 | 3.00e-02 | 4 |
GO:200073611 | Cervix | N_HPV | regulation of stem cell differentiation | 6/534 | 58/18723 | 6.04e-03 | 4.17e-02 | 6 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:00017012 | Colorectum | MSS | in utero embryonic development | 99/3467 | 367/18723 | 3.71e-05 | 7.10e-04 | 99 |
GO:0002244 | Colorectum | MSS | hematopoietic progenitor cell differentiation | 32/3467 | 114/18723 | 8.07e-03 | 4.91e-02 | 32 |
GO:00017013 | Colorectum | FAP | in utero embryonic development | 81/2622 | 367/18723 | 1.58e-05 | 4.10e-04 | 81 |
GO:00022441 | Colorectum | FAP | hematopoietic progenitor cell differentiation | 29/2622 | 114/18723 | 8.35e-04 | 8.71e-03 | 29 |
GO:0048863 | Colorectum | FAP | stem cell differentiation | 44/2622 | 206/18723 | 2.48e-03 | 1.96e-02 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
N4BP2 | SNV | Missense_Mutation | c.3085N>C | p.Glu1029Gln | p.E1029Q | Q86UW6 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
N4BP2 | SNV | Missense_Mutation | novel | c.2583N>T | p.Glu861Asp | p.E861D | Q86UW6 | protein_coding | deleterious(0.04) | possibly_damaging(0.757) | TCGA-VS-A952-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
N4BP2 | SNV | Missense_Mutation | novel | c.4204C>G | p.Leu1402Val | p.L1402V | Q86UW6 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-VS-A9UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
N4BP2 | SNV | Missense_Mutation | c.359N>A | p.Arg120His | p.R120H | Q86UW6 | protein_coding | tolerated(0.55) | benign(0) | TCGA-AA-3819-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
N4BP2 | SNV | Missense_Mutation | novel | c.4039N>C | p.Ser1347Arg | p.S1347R | Q86UW6 | protein_coding | tolerated(0.08) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
N4BP2 | SNV | Missense_Mutation | novel | c.2743N>C | p.Asn915His | p.N915H | Q86UW6 | protein_coding | deleterious(0.05) | benign(0.275) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
N4BP2 | SNV | Missense_Mutation | c.446N>T | p.Ala149Val | p.A149V | Q86UW6 | protein_coding | deleterious(0) | possibly_damaging(0.861) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
N4BP2 | SNV | Missense_Mutation | novel | c.902N>G | p.Asp301Gly | p.D301G | Q86UW6 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
N4BP2 | SNV | Missense_Mutation | c.551N>T | p.Ser184Leu | p.S184L | Q86UW6 | protein_coding | deleterious(0.03) | benign(0.063) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
N4BP2 | SNV | Missense_Mutation | rs765712814 | c.2921N>T | p.Ser974Leu | p.S974L | Q86UW6 | protein_coding | deleterious(0.05) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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