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Gene: MYO5C |
Gene summary for MYO5C |
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Gene information | Species | Human | Gene symbol | MYO5C | Gene ID | 55930 |
Gene name | myosin VC | |
Gene Alias | MYO5C | |
Cytomap | 15q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NQX4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55930 | MYO5C | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.63e-03 | -2.85e-01 | 0.0155 |
55930 | MYO5C | HTA11_347_2000001011 | Human | Colorectum | AD | 2.08e-04 | 4.90e-01 | -0.1954 |
55930 | MYO5C | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.38e-10 | -4.29e-01 | 0.3859 |
55930 | MYO5C | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.56e-09 | -4.07e-01 | 0.3005 |
55930 | MYO5C | F007 | Human | Colorectum | FAP | 1.16e-05 | -3.64e-01 | 0.1176 |
55930 | MYO5C | A001-C-207 | Human | Colorectum | FAP | 2.61e-06 | -2.00e-01 | 0.1278 |
55930 | MYO5C | A015-C-203 | Human | Colorectum | FAP | 3.06e-33 | -4.58e-01 | -0.1294 |
55930 | MYO5C | A015-C-204 | Human | Colorectum | FAP | 1.05e-07 | -2.63e-01 | -0.0228 |
55930 | MYO5C | A014-C-040 | Human | Colorectum | FAP | 5.49e-08 | -4.68e-01 | -0.1184 |
55930 | MYO5C | A002-C-201 | Human | Colorectum | FAP | 2.16e-17 | -2.65e-01 | 0.0324 |
55930 | MYO5C | A002-C-203 | Human | Colorectum | FAP | 9.55e-09 | -1.91e-01 | 0.2786 |
55930 | MYO5C | A001-C-119 | Human | Colorectum | FAP | 1.46e-06 | -5.02e-03 | -0.1557 |
55930 | MYO5C | A001-C-108 | Human | Colorectum | FAP | 6.20e-20 | -1.57e-01 | -0.0272 |
55930 | MYO5C | A002-C-205 | Human | Colorectum | FAP | 6.41e-27 | -1.55e-01 | -0.1236 |
55930 | MYO5C | A001-C-104 | Human | Colorectum | FAP | 4.49e-03 | -9.50e-02 | 0.0184 |
55930 | MYO5C | A015-C-005 | Human | Colorectum | FAP | 4.20e-03 | 6.24e-03 | -0.0336 |
55930 | MYO5C | A015-C-006 | Human | Colorectum | FAP | 7.58e-18 | -2.73e-01 | -0.0994 |
55930 | MYO5C | A015-C-106 | Human | Colorectum | FAP | 5.76e-17 | -1.64e-01 | -0.0511 |
55930 | MYO5C | A002-C-114 | Human | Colorectum | FAP | 6.53e-22 | -2.16e-01 | -0.1561 |
55930 | MYO5C | A015-C-104 | Human | Colorectum | FAP | 1.56e-36 | -2.44e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0051650 | Colorectum | AD | establishment of vesicle localization | 57/3918 | 161/18723 | 1.47e-05 | 3.15e-04 | 57 |
GO:0051648 | Colorectum | AD | vesicle localization | 59/3918 | 177/18723 | 7.83e-05 | 1.25e-03 | 59 |
GO:0030048 | Colorectum | AD | actin filament-based movement | 44/3918 | 127/18723 | 2.31e-04 | 2.99e-03 | 44 |
GO:0099515 | Colorectum | AD | actin filament-based transport | 12/3918 | 21/18723 | 3.02e-04 | 3.62e-03 | 12 |
GO:0030050 | Colorectum | AD | vesicle transport along actin filament | 11/3918 | 19/18723 | 4.66e-04 | 5.15e-03 | 11 |
GO:0030705 | Colorectum | AD | cytoskeleton-dependent intracellular transport | 60/3918 | 195/18723 | 7.56e-04 | 7.59e-03 | 60 |
GO:00070152 | Colorectum | MSS | actin filament organization | 146/3467 | 442/18723 | 1.16e-13 | 2.67e-11 | 146 |
GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
GO:00300482 | Colorectum | MSS | actin filament-based movement | 44/3467 | 127/18723 | 1.11e-05 | 2.64e-04 | 44 |
GO:00516502 | Colorectum | MSS | establishment of vesicle localization | 51/3467 | 161/18723 | 3.92e-05 | 7.45e-04 | 51 |
GO:00516482 | Colorectum | MSS | vesicle localization | 53/3467 | 177/18723 | 1.47e-04 | 2.16e-03 | 53 |
GO:00995152 | Colorectum | MSS | actin filament-based transport | 11/3467 | 21/18723 | 4.85e-04 | 5.65e-03 | 11 |
GO:00300502 | Colorectum | MSS | vesicle transport along actin filament | 10/3467 | 19/18723 | 8.39e-04 | 8.68e-03 | 10 |
GO:00307052 | Colorectum | MSS | cytoskeleton-dependent intracellular transport | 52/3467 | 195/18723 | 3.07e-03 | 2.34e-02 | 52 |
GO:00070154 | Colorectum | FAP | actin filament organization | 125/2622 | 442/18723 | 1.97e-15 | 3.03e-12 | 125 |
GO:00300483 | Colorectum | FAP | actin filament-based movement | 44/2622 | 127/18723 | 3.48e-09 | 5.93e-07 | 44 |
GO:00516563 | Colorectum | FAP | establishment of organelle localization | 97/2622 | 390/18723 | 5.91e-09 | 9.48e-07 | 97 |
GO:00516503 | Colorectum | FAP | establishment of vesicle localization | 48/2622 | 161/18723 | 1.56e-07 | 9.64e-06 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05130 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa051301 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa051304 | Colorectum | MSS | Pathogenic Escherichia coli infection | 73/1875 | 197/8465 | 1.10e-06 | 1.48e-05 | 9.06e-06 | 73 |
hsa051305 | Colorectum | MSS | Pathogenic Escherichia coli infection | 73/1875 | 197/8465 | 1.10e-06 | 1.48e-05 | 9.06e-06 | 73 |
hsa051308 | Colorectum | FAP | Pathogenic Escherichia coli infection | 62/1404 | 197/8465 | 1.37e-07 | 3.08e-06 | 1.87e-06 | 62 |
hsa051309 | Colorectum | FAP | Pathogenic Escherichia coli infection | 62/1404 | 197/8465 | 1.37e-07 | 3.08e-06 | 1.87e-06 | 62 |
hsa0513010 | Colorectum | CRC | Pathogenic Escherichia coli infection | 47/1091 | 197/8465 | 1.49e-05 | 3.84e-04 | 2.60e-04 | 47 |
hsa0513011 | Colorectum | CRC | Pathogenic Escherichia coli infection | 47/1091 | 197/8465 | 1.49e-05 | 3.84e-04 | 2.60e-04 | 47 |
hsa05130211 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa05130310 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa0513016 | Lung | IAC | Pathogenic Escherichia coli infection | 45/1053 | 197/8465 | 2.93e-05 | 6.14e-04 | 4.08e-04 | 45 |
hsa0513017 | Lung | IAC | Pathogenic Escherichia coli infection | 45/1053 | 197/8465 | 2.93e-05 | 6.14e-04 | 4.08e-04 | 45 |
hsa0513023 | Lung | AIS | Pathogenic Escherichia coli infection | 42/961 | 197/8465 | 3.43e-05 | 5.62e-04 | 3.59e-04 | 42 |
hsa0513033 | Lung | AIS | Pathogenic Escherichia coli infection | 42/961 | 197/8465 | 3.43e-05 | 5.62e-04 | 3.59e-04 | 42 |
hsa04814 | Lung | MIAC | Motor proteins | 21/507 | 193/8465 | 5.64e-03 | 3.82e-02 | 2.76e-02 | 21 |
hsa048141 | Lung | MIAC | Motor proteins | 21/507 | 193/8465 | 5.64e-03 | 3.82e-02 | 2.76e-02 | 21 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYO5C | SNV | Missense_Mutation | c.1609G>C | p.Glu537Gln | p.E537Q | Q9NQX4 | protein_coding | tolerated(0.56) | benign(0.173) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
MYO5C | SNV | Missense_Mutation | c.3711N>C | p.Glu1237Asp | p.E1237D | Q9NQX4 | protein_coding | tolerated(0.4) | benign(0) | TCGA-LP-A4AX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MYO5C | SNV | Missense_Mutation | rs766392804 | c.2599N>T | p.Arg867Trp | p.R867W | Q9NQX4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A8QM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
MYO5C | SNV | Missense_Mutation | rs370937670 | c.2617N>T | p.Arg873Cys | p.R873C | Q9NQX4 | protein_coding | deleterious(0.01) | possibly_damaging(0.616) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MYO5C | SNV | Missense_Mutation | rs762003225 | c.1448N>T | p.Thr483Met | p.T483M | Q9NQX4 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
MYO5C | SNV | Missense_Mutation | rs547849749 | c.3593N>A | p.Arg1198His | p.R1198H | Q9NQX4 | protein_coding | tolerated(0.08) | possibly_damaging(0.629) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYO5C | SNV | Missense_Mutation | c.2596N>A | p.Ala866Thr | p.A866T | Q9NQX4 | protein_coding | tolerated(0.14) | possibly_damaging(0.739) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYO5C | SNV | Missense_Mutation | c.944N>C | p.Phe315Ser | p.F315S | Q9NQX4 | protein_coding | deleterious(0) | possibly_damaging(0.511) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
MYO5C | SNV | Missense_Mutation | rs375271766 | c.2603C>T | p.Ala868Val | p.A868V | Q9NQX4 | protein_coding | deleterious(0) | benign(0.36) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MYO5C | SNV | Missense_Mutation | c.3116N>G | p.Glu1039Gly | p.E1039G | Q9NQX4 | protein_coding | deleterious(0.01) | possibly_damaging(0.754) | TCGA-AA-3867-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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