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Gene: MUC5B |
Gene summary for MUC5B |
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Gene information | Species | Human | Gene symbol | MUC5B | Gene ID | 727897 |
Gene name | mucin 5B, oligomeric mucus/gel-forming | |
Gene Alias | MG1 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9HC84 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
727897 | MUC5B | CA_HPV_1 | Human | Cervix | CC | 1.81e-35 | -9.75e-01 | 0.0264 |
727897 | MUC5B | CA_HPV_2 | Human | Cervix | CC | 2.07e-26 | -9.50e-01 | 0.0391 |
727897 | MUC5B | CA_HPV_3 | Human | Cervix | CC | 2.34e-23 | -9.25e-01 | 0.0414 |
727897 | MUC5B | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 3.87e-06 | -5.97e-01 | 0.0116 |
727897 | MUC5B | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 3.52e-05 | -1.91e-01 | 0.0208 |
727897 | MUC5B | N_HPV_1 | Human | Cervix | N_HPV | 2.88e-09 | -6.64e-01 | 0.0079 |
727897 | MUC5B | N_HPV_2 | Human | Cervix | N_HPV | 1.75e-08 | -6.64e-01 | -0.0131 |
727897 | MUC5B | CCI_1 | Human | Cervix | CC | 4.44e-10 | -9.75e-01 | 0.528 |
727897 | MUC5B | CCI_2 | Human | Cervix | CC | 3.15e-09 | -9.75e-01 | 0.5249 |
727897 | MUC5B | CCI_3 | Human | Cervix | CC | 1.68e-13 | -9.75e-01 | 0.516 |
727897 | MUC5B | CCII_1 | Human | Cervix | CC | 1.00e-18 | -9.75e-01 | 0.3249 |
727897 | MUC5B | Tumor | Human | Cervix | CC | 7.90e-34 | -9.75e-01 | 0.1241 |
727897 | MUC5B | sample1 | Human | Cervix | CC | 1.18e-15 | -9.75e-01 | 0.0959 |
727897 | MUC5B | sample3 | Human | Cervix | CC | 2.01e-33 | -9.75e-01 | 0.1387 |
727897 | MUC5B | H2 | Human | Cervix | HSIL_HPV | 2.62e-38 | 9.26e-01 | 0.0632 |
727897 | MUC5B | L1 | Human | Cervix | CC | 1.55e-20 | -9.75e-01 | 0.0802 |
727897 | MUC5B | T1 | Human | Cervix | CC | 6.11e-31 | -9.69e-01 | 0.0918 |
727897 | MUC5B | T3 | Human | Cervix | CC | 4.67e-35 | -9.75e-01 | 0.1389 |
727897 | MUC5B | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.69e-09 | -5.26e-01 | 0.0155 |
727897 | MUC5B | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.86e-06 | -6.05e-01 | -0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0465718 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0465719 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0465722 | Cervix | HSIL_HPV | IL-17 signaling pathway | 15/459 | 94/8465 | 1.45e-04 | 1.74e-03 | 1.40e-03 | 15 |
hsa0465732 | Cervix | HSIL_HPV | IL-17 signaling pathway | 15/459 | 94/8465 | 1.45e-04 | 1.74e-03 | 1.40e-03 | 15 |
hsa0465742 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa0465752 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa04970 | Colorectum | FAP | Salivary secretion | 24/1404 | 93/8465 | 1.52e-02 | 4.99e-02 | 3.03e-02 | 24 |
hsa049701 | Colorectum | FAP | Salivary secretion | 24/1404 | 93/8465 | 1.52e-02 | 4.99e-02 | 3.03e-02 | 24 |
hsa049702 | Colorectum | CRC | Salivary secretion | 22/1091 | 93/8465 | 3.03e-03 | 1.91e-02 | 1.29e-02 | 22 |
hsa049703 | Colorectum | CRC | Salivary secretion | 22/1091 | 93/8465 | 3.03e-03 | 1.91e-02 | 1.29e-02 | 22 |
hsa0465720 | Endometrium | EEC | IL-17 signaling pathway | 23/1237 | 94/8465 | 7.61e-03 | 3.63e-02 | 2.71e-02 | 23 |
hsa04657110 | Endometrium | EEC | IL-17 signaling pathway | 23/1237 | 94/8465 | 7.61e-03 | 3.63e-02 | 2.71e-02 | 23 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUC5B | SNV | Missense_Mutation | rs200708304 | c.10075N>C | p.Ala3359Pro | p.A3359P | Q9HC84 | protein_coding | tolerated(0.27) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
MUC5B | SNV | Missense_Mutation | novel | c.8787G>C | p.Glu2929Asp | p.E2929D | Q9HC84 | protein_coding | tolerated(0.26) | benign(0.026) | TCGA-AQ-A54N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MUC5B | SNV | Missense_Mutation | rs779700720 | c.1399N>T | p.Arg467Trp | p.R467W | Q9HC84 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AR-A24X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
MUC5B | SNV | Missense_Mutation | c.1780N>G | p.Gln594Glu | p.Q594E | Q9HC84 | protein_coding | deleterious(0.04) | possibly_damaging(0.622) | TCGA-BH-A0BL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
MUC5B | SNV | Missense_Mutation | rs375100525 | c.10475N>T | p.Ser3492Phe | p.S3492F | Q9HC84 | protein_coding | tolerated(0.1) | benign(0.007) | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
MUC5B | SNV | Missense_Mutation | rs748784024 | c.2207N>T | p.Ala736Val | p.A736V | Q9HC84 | protein_coding | tolerated(0.26) | benign(0.015) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MUC5B | SNV | Missense_Mutation | rs569128267 | c.15583N>A | p.Val5195Met | p.V5195M | Q9HC84 | protein_coding | deleterious(0.01) | possibly_damaging(0.46) | TCGA-BH-A1FM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MUC5B | SNV | Missense_Mutation | c.10731N>C | p.Trp3577Cys | p.W3577C | Q9HC84 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BH-A208-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MUC5B | SNV | Missense_Mutation | rs542178907 | c.11621C>A | p.Thr3874Lys | p.T3874K | Q9HC84 | protein_coding | tolerated(0.16) | benign(0.334) | TCGA-BH-A42V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MUC5B | SNV | Missense_Mutation | rs377582994 | c.14752G>A | p.Val4918Met | p.V4918M | Q9HC84 | protein_coding | tolerated(0.56) | benign(0.012) | TCGA-C8-A12O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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