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Gene: MUC13 |
Gene summary for MUC13 |
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Gene information | Species | Human | Gene symbol | MUC13 | Gene ID | 56667 |
Gene name | mucin 13, cell surface associated | |
Gene Alias | DRCC1 | |
Cytomap | 3q21.2 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | Q9H3R2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56667 | MUC13 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.71e-21 | 1.59e+00 | -0.1808 |
56667 | MUC13 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.63e-16 | 1.03e+00 | -0.0811 |
56667 | MUC13 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.23e-04 | 5.73e-01 | -0.1088 |
56667 | MUC13 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.41e-40 | 1.49e+00 | -0.1954 |
56667 | MUC13 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.41e-14 | 2.87e+00 | -0.2602 |
56667 | MUC13 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.46e-14 | 2.26e+00 | -0.2196 |
56667 | MUC13 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.88e-10 | 8.11e-01 | -0.1207 |
56667 | MUC13 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.06e-09 | 8.65e-01 | -0.1526 |
56667 | MUC13 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.83e-27 | 1.23e+00 | -0.1464 |
56667 | MUC13 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.84e-10 | 8.36e-01 | -0.1001 |
56667 | MUC13 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.61e-33 | 1.69e+00 | -0.059 |
56667 | MUC13 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.59e-05 | 9.83e-01 | -0.1706 |
56667 | MUC13 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.35e-13 | 1.82e+00 | -0.2061 |
56667 | MUC13 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.09e-04 | 1.00e+00 | -0.1462 |
56667 | MUC13 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.75e-07 | 6.84e-01 | -0.0842 |
56667 | MUC13 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.89e-03 | 4.56e-01 | -0.0179 |
56667 | MUC13 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.06e-21 | 8.89e-01 | 0.096 |
56667 | MUC13 | HTA11_7663_2000001011 | Human | Colorectum | SER | 8.14e-05 | 8.28e-01 | 0.0131 |
56667 | MUC13 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.04e-03 | 4.45e-01 | 0.0338 |
56667 | MUC13 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.02e-06 | 5.66e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
GO:0030277 | Colorectum | AD | maintenance of gastrointestinal epithelium | 10/3918 | 22/18723 | 8.52e-03 | 4.97e-02 | 10 |
GO:00018941 | Colorectum | SER | tissue homeostasis | 66/2897 | 268/18723 | 5.87e-05 | 1.37e-03 | 66 |
GO:00602491 | Colorectum | SER | anatomical structure homeostasis | 74/2897 | 314/18723 | 1.01e-04 | 2.13e-03 | 74 |
GO:0022600 | Colorectum | SER | digestive system process | 29/2897 | 104/18723 | 8.57e-04 | 1.05e-02 | 29 |
GO:00602492 | Colorectum | MSS | anatomical structure homeostasis | 84/3467 | 314/18723 | 1.87e-04 | 2.64e-03 | 84 |
GO:00018942 | Colorectum | MSS | tissue homeostasis | 72/3467 | 268/18723 | 4.53e-04 | 5.40e-03 | 72 |
GO:00226001 | Colorectum | MSS | digestive system process | 31/3467 | 104/18723 | 3.46e-03 | 2.59e-02 | 31 |
GO:00602493 | Colorectum | MSI-H | anatomical structure homeostasis | 38/1319 | 314/18723 | 7.73e-04 | 1.44e-02 | 38 |
GO:00018943 | Colorectum | MSI-H | tissue homeostasis | 33/1319 | 268/18723 | 1.24e-03 | 2.00e-02 | 33 |
GO:00302771 | Colorectum | MSI-H | maintenance of gastrointestinal epithelium | 6/1319 | 22/18723 | 3.38e-03 | 4.07e-02 | 6 |
GO:00018944 | Colorectum | FAP | tissue homeostasis | 61/2622 | 268/18723 | 6.71e-05 | 1.28e-03 | 61 |
GO:00602494 | Colorectum | FAP | anatomical structure homeostasis | 69/2622 | 314/18723 | 7.51e-05 | 1.37e-03 | 69 |
GO:0010669 | Colorectum | FAP | epithelial structure maintenance | 10/2622 | 30/18723 | 5.90e-03 | 3.75e-02 | 10 |
GO:00302772 | Colorectum | FAP | maintenance of gastrointestinal epithelium | 8/2622 | 22/18723 | 7.51e-03 | 4.47e-02 | 8 |
GO:00226002 | Colorectum | FAP | digestive system process | 24/2622 | 104/18723 | 8.41e-03 | 4.89e-02 | 24 |
GO:00602495 | Colorectum | CRC | anatomical structure homeostasis | 57/2078 | 314/18723 | 1.24e-04 | 2.41e-03 | 57 |
GO:00018945 | Colorectum | CRC | tissue homeostasis | 48/2078 | 268/18723 | 5.56e-04 | 7.70e-03 | 48 |
GO:00226003 | Colorectum | CRC | digestive system process | 21/2078 | 104/18723 | 4.67e-03 | 3.62e-02 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUC13 | SNV | Missense_Mutation | novel | c.952N>G | p.Leu318Val | p.L318V | Q9H3R2 | protein_coding | tolerated(0.29) | benign(0.037) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
MUC13 | SNV | Missense_Mutation | novel | c.550N>C | p.Asp184His | p.D184H | Q9H3R2 | protein_coding | tolerated(0.09) | probably_damaging(0.96) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MUC13 | SNV | Missense_Mutation | novel | c.944N>A | p.Ser315Asn | p.S315N | Q9H3R2 | protein_coding | tolerated(0.42) | benign(0.022) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MUC13 | SNV | Missense_Mutation | rs758163036 | c.973N>T | p.Arg325Trp | p.R325W | Q9H3R2 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MUC13 | SNV | Missense_Mutation | rs777698206 | c.1240G>A | p.Asp414Asn | p.D414N | Q9H3R2 | protein_coding | tolerated(0.79) | benign(0.038) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
MUC13 | SNV | Missense_Mutation | rs142060793 | c.1288N>A | p.Ala430Thr | p.A430T | Q9H3R2 | protein_coding | deleterious(0.02) | probably_damaging(0.948) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
MUC13 | SNV | Missense_Mutation | novel | c.1400N>G | p.Leu467Arg | p.L467R | Q9H3R2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A01V-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MUC13 | SNV | Missense_Mutation | rs368207084 | c.829N>T | p.Arg277Cys | p.R277C | Q9H3R2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MUC13 | SNV | Missense_Mutation | novel | c.113N>A | p.Pro38His | p.P38H | Q9H3R2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.736) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MUC13 | deletion | Frame_Shift_Del | novel | c.264delC | p.Ile89Ter | p.I89* | Q9H3R2 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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