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Gene: MTO1 |
Gene summary for MTO1 |
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Gene information | Species | Human | Gene symbol | MTO1 | Gene ID | 25821 |
Gene name | mitochondrial tRNA translation optimization 1 | |
Gene Alias | CGI-02 | |
Cytomap | 6q13 | |
Gene Type | protein-coding | GO ID | GO:0000959 | UniProtAcc | Q9Y2Z2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25821 | MTO1 | LZE4T | Human | Esophagus | ESCC | 1.78e-08 | 2.16e-01 | 0.0811 |
25821 | MTO1 | LZE7T | Human | Esophagus | ESCC | 3.31e-02 | 1.32e-01 | 0.0667 |
25821 | MTO1 | LZE24T | Human | Esophagus | ESCC | 1.88e-12 | 2.27e-01 | 0.0596 |
25821 | MTO1 | P1T-E | Human | Esophagus | ESCC | 2.06e-04 | 2.15e-01 | 0.0875 |
25821 | MTO1 | P2T-E | Human | Esophagus | ESCC | 3.56e-09 | 2.47e-01 | 0.1177 |
25821 | MTO1 | P4T-E | Human | Esophagus | ESCC | 2.55e-11 | 1.90e-01 | 0.1323 |
25821 | MTO1 | P5T-E | Human | Esophagus | ESCC | 2.34e-14 | 1.71e-01 | 0.1327 |
25821 | MTO1 | P8T-E | Human | Esophagus | ESCC | 4.66e-06 | 1.28e-01 | 0.0889 |
25821 | MTO1 | P9T-E | Human | Esophagus | ESCC | 1.97e-05 | 1.70e-01 | 0.1131 |
25821 | MTO1 | P10T-E | Human | Esophagus | ESCC | 7.49e-08 | 1.28e-01 | 0.116 |
25821 | MTO1 | P11T-E | Human | Esophagus | ESCC | 1.58e-06 | 3.18e-01 | 0.1426 |
25821 | MTO1 | P12T-E | Human | Esophagus | ESCC | 6.36e-18 | 2.73e-01 | 0.1122 |
25821 | MTO1 | P15T-E | Human | Esophagus | ESCC | 2.52e-09 | 2.02e-01 | 0.1149 |
25821 | MTO1 | P16T-E | Human | Esophagus | ESCC | 3.53e-16 | 2.23e-01 | 0.1153 |
25821 | MTO1 | P19T-E | Human | Esophagus | ESCC | 8.10e-10 | 5.01e-01 | 0.1662 |
25821 | MTO1 | P20T-E | Human | Esophagus | ESCC | 5.76e-05 | 9.53e-02 | 0.1124 |
25821 | MTO1 | P21T-E | Human | Esophagus | ESCC | 1.81e-18 | 2.81e-01 | 0.1617 |
25821 | MTO1 | P22T-E | Human | Esophagus | ESCC | 3.05e-11 | 1.37e-01 | 0.1236 |
25821 | MTO1 | P23T-E | Human | Esophagus | ESCC | 1.72e-15 | 3.05e-01 | 0.108 |
25821 | MTO1 | P24T-E | Human | Esophagus | ESCC | 1.93e-14 | 1.50e-01 | 0.1287 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00009592 | Esophagus | ESCC | mitochondrial RNA metabolic process | 39/8552 | 49/18723 | 1.20e-06 | 1.49e-05 | 39 |
GO:00009631 | Esophagus | ESCC | mitochondrial RNA processing | 19/8552 | 20/18723 | 3.83e-06 | 4.14e-05 | 19 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
GO:0090646 | Esophagus | ESCC | mitochondrial tRNA processing | 11/8552 | 12/18723 | 1.26e-03 | 6.06e-03 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTO1 | SNV | Missense_Mutation | novel | c.1827N>C | p.Leu609Phe | p.L609F | Q9Y2Z2 | protein_coding | tolerated(0.19) | benign(0.113) | TCGA-VS-A8EI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MTO1 | SNV | Missense_Mutation | c.1993N>C | p.Ser665Pro | p.S665P | Q9Y2Z2 | protein_coding | deleterious(0.02) | possibly_damaging(0.601) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTO1 | SNV | Missense_Mutation | c.701N>T | p.Arg234Met | p.R234M | Q9Y2Z2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTO1 | SNV | Missense_Mutation | rs764063598 | c.725N>A | p.Arg242Gln | p.R242Q | Q9Y2Z2 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTO1 | SNV | Missense_Mutation | rs763571382 | c.350N>A | p.Arg117His | p.R117H | Q9Y2Z2 | protein_coding | deleterious(0.01) | possibly_damaging(0.88) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MTO1 | SNV | Missense_Mutation | novel | c.1041N>T | p.Gln347His | p.Q347H | Q9Y2Z2 | protein_coding | deleterious(0.01) | probably_damaging(0.974) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTO1 | SNV | Missense_Mutation | c.1956N>T | p.Lys652Asn | p.K652N | Q9Y2Z2 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MTO1 | SNV | Missense_Mutation | rs370046018 | c.514N>T | p.Arg172Cys | p.R172C | Q9Y2Z2 | protein_coding | tolerated(0.13) | benign(0.048) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTO1 | SNV | Missense_Mutation | c.1214N>T | p.Ala405Val | p.A405V | Q9Y2Z2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MTO1 | SNV | Missense_Mutation | rs754116708 | c.1765N>A | p.Asp589Asn | p.D589N | Q9Y2Z2 | protein_coding | deleterious(0.02) | possibly_damaging(0.479) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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