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Gene: MTFR1L |
Gene summary for MTFR1L |
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Gene information | Species | Human | Gene symbol | MTFR1L | Gene ID | 56181 |
Gene name | mitochondrial fission regulator 1 like | |
Gene Alias | FAM54B | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0000266 | UniProtAcc | A0A0S2Z5H6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56181 | MTFR1L | LZE7T | Human | Esophagus | ESCC | 1.27e-03 | 2.65e-01 | 0.0667 |
56181 | MTFR1L | LZE8T | Human | Esophagus | ESCC | 4.87e-04 | 2.07e-01 | 0.067 |
56181 | MTFR1L | LZE24T | Human | Esophagus | ESCC | 1.40e-09 | 2.73e-01 | 0.0596 |
56181 | MTFR1L | P1T-E | Human | Esophagus | ESCC | 2.28e-04 | 2.62e-01 | 0.0875 |
56181 | MTFR1L | P2T-E | Human | Esophagus | ESCC | 3.34e-26 | 4.30e-01 | 0.1177 |
56181 | MTFR1L | P4T-E | Human | Esophagus | ESCC | 8.75e-09 | 2.04e-01 | 0.1323 |
56181 | MTFR1L | P5T-E | Human | Esophagus | ESCC | 1.68e-03 | 8.37e-02 | 0.1327 |
56181 | MTFR1L | P8T-E | Human | Esophagus | ESCC | 2.91e-15 | 2.04e-01 | 0.0889 |
56181 | MTFR1L | P9T-E | Human | Esophagus | ESCC | 3.61e-08 | 2.51e-01 | 0.1131 |
56181 | MTFR1L | P10T-E | Human | Esophagus | ESCC | 4.65e-36 | 5.42e-01 | 0.116 |
56181 | MTFR1L | P11T-E | Human | Esophagus | ESCC | 1.76e-06 | 4.57e-01 | 0.1426 |
56181 | MTFR1L | P12T-E | Human | Esophagus | ESCC | 2.35e-23 | 3.22e-01 | 0.1122 |
56181 | MTFR1L | P15T-E | Human | Esophagus | ESCC | 1.28e-17 | 2.97e-01 | 0.1149 |
56181 | MTFR1L | P16T-E | Human | Esophagus | ESCC | 1.67e-21 | 2.61e-01 | 0.1153 |
56181 | MTFR1L | P17T-E | Human | Esophagus | ESCC | 4.12e-04 | 3.04e-01 | 0.1278 |
56181 | MTFR1L | P20T-E | Human | Esophagus | ESCC | 2.00e-12 | 2.89e-01 | 0.1124 |
56181 | MTFR1L | P21T-E | Human | Esophagus | ESCC | 3.39e-20 | 3.60e-01 | 0.1617 |
56181 | MTFR1L | P22T-E | Human | Esophagus | ESCC | 1.52e-11 | 1.37e-01 | 0.1236 |
56181 | MTFR1L | P23T-E | Human | Esophagus | ESCC | 5.35e-16 | 3.00e-01 | 0.108 |
56181 | MTFR1L | P24T-E | Human | Esophagus | ESCC | 1.68e-11 | 1.29e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0045333110 | Esophagus | ESCC | cellular respiration | 173/8552 | 230/18723 | 4.53e-20 | 5.99e-18 | 173 |
GO:0009060110 | Esophagus | ESCC | aerobic respiration | 145/8552 | 189/18723 | 2.16e-18 | 2.21e-16 | 145 |
GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00002662 | Esophagus | ESCC | mitochondrial fission | 28/8552 | 42/18723 | 4.90e-03 | 1.89e-02 | 28 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:000906012 | Liver | HCC | aerobic respiration | 147/7958 | 189/18723 | 3.13e-23 | 6.61e-21 | 147 |
GO:004533312 | Liver | HCC | cellular respiration | 171/7958 | 230/18723 | 6.35e-23 | 1.26e-20 | 171 |
GO:001598022 | Liver | HCC | energy derivation by oxidation of organic compounds | 221/7958 | 318/18723 | 1.02e-22 | 1.86e-20 | 221 |
GO:0048285 | Liver | HCC | organelle fission | 254/7958 | 488/18723 | 1.07e-05 | 1.23e-04 | 254 |
GO:0000266 | Liver | HCC | mitochondrial fission | 28/7958 | 42/18723 | 1.35e-03 | 7.26e-03 | 28 |
GO:000609118 | Oral cavity | OSCC | generation of precursor metabolites and energy | 286/7305 | 490/18723 | 1.45e-18 | 1.71e-16 | 286 |
GO:000906018 | Oral cavity | OSCC | aerobic respiration | 133/7305 | 189/18723 | 1.79e-18 | 2.02e-16 | 133 |
GO:004533318 | Oral cavity | OSCC | cellular respiration | 153/7305 | 230/18723 | 2.07e-17 | 1.87e-15 | 153 |
GO:001598018 | Oral cavity | OSCC | energy derivation by oxidation of organic compounds | 190/7305 | 318/18723 | 4.10e-14 | 2.26e-12 | 190 |
GO:00482852 | Oral cavity | OSCC | organelle fission | 265/7305 | 488/18723 | 3.22e-12 | 1.27e-10 | 265 |
GO:00002661 | Oral cavity | OSCC | mitochondrial fission | 24/7305 | 42/18723 | 1.30e-02 | 4.34e-02 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTFR1L | SNV | Missense_Mutation | rs781356037 | c.671C>T | p.Ser224Leu | p.S224L | Q9H019 | protein_coding | tolerated(0.28) | benign(0) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
MTFR1L | SNV | Missense_Mutation | c.400G>A | p.Glu134Lys | p.E134K | Q9H019 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTFR1L | SNV | Missense_Mutation | rs765430944 | c.250N>T | p.Arg84Cys | p.R84C | Q9H019 | protein_coding | deleterious(0.04) | benign(0.011) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTFR1L | SNV | Missense_Mutation | rs770267388 | c.415C>T | p.Arg139Cys | p.R139C | Q9H019 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-D1-A163-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
MTFR1L | SNV | Missense_Mutation | c.814A>G | p.Ile272Val | p.I272V | Q9H019 | protein_coding | deleterious(0.05) | possibly_damaging(0.898) | TCGA-ED-A459-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Ancillary | alvesin | CR | |
MTFR1L | SNV | Missense_Mutation | c.502N>C | p.Ser168Pro | p.S168P | Q9H019 | protein_coding | deleterious(0.02) | possibly_damaging(0.829) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MTFR1L | SNV | Missense_Mutation | c.772C>G | p.Leu258Val | p.L258V | Q9H019 | protein_coding | tolerated(0.5) | benign(0.191) | TCGA-86-8279-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR | |
MTFR1L | SNV | Missense_Mutation | novel | c.638N>A | p.Cys213Tyr | p.C213Y | Q9H019 | protein_coding | tolerated(1) | possibly_damaging(0.762) | TCGA-CV-A45P-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MTFR1L | SNV | Missense_Mutation | c.227N>G | p.Tyr76Cys | p.Y76C | Q9H019 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
MTFR1L | SNV | Missense_Mutation | c.628N>G | p.Ser210Gly | p.S210G | Q9H019 | protein_coding | deleterious(0.02) | benign(0.026) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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