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Gene: MSRB3 |
Gene summary for MSRB3 |
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Gene information | Species | Human | Gene symbol | MSRB3 | Gene ID | 253827 |
Gene name | methionine sulfoxide reductase B3 | |
Gene Alias | DFNB74 | |
Cytomap | 12q14.3 | |
Gene Type | protein-coding | GO ID | GO:0006807 | UniProtAcc | Q8IXL7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
253827 | MSRB3 | LZE7T | Human | Esophagus | ESCC | 1.18e-06 | 2.80e-01 | 0.0667 |
253827 | MSRB3 | P2T-E | Human | Esophagus | ESCC | 1.63e-22 | 4.58e-01 | 0.1177 |
253827 | MSRB3 | P4T-E | Human | Esophagus | ESCC | 5.05e-06 | 2.33e-01 | 0.1323 |
253827 | MSRB3 | P5T-E | Human | Esophagus | ESCC | 7.03e-03 | 1.67e-01 | 0.1327 |
253827 | MSRB3 | P8T-E | Human | Esophagus | ESCC | 7.30e-10 | 2.96e-01 | 0.0889 |
253827 | MSRB3 | P9T-E | Human | Esophagus | ESCC | 4.07e-08 | 2.94e-01 | 0.1131 |
253827 | MSRB3 | P10T-E | Human | Esophagus | ESCC | 7.31e-19 | 3.59e-01 | 0.116 |
253827 | MSRB3 | P12T-E | Human | Esophagus | ESCC | 4.12e-06 | 2.04e-01 | 0.1122 |
253827 | MSRB3 | P15T-E | Human | Esophagus | ESCC | 3.32e-13 | 3.60e-01 | 0.1149 |
253827 | MSRB3 | P16T-E | Human | Esophagus | ESCC | 5.19e-04 | 1.59e-01 | 0.1153 |
253827 | MSRB3 | P19T-E | Human | Esophagus | ESCC | 4.38e-04 | 6.28e-01 | 0.1662 |
253827 | MSRB3 | P22T-E | Human | Esophagus | ESCC | 9.93e-07 | 1.77e-01 | 0.1236 |
253827 | MSRB3 | P23T-E | Human | Esophagus | ESCC | 4.68e-10 | 3.16e-01 | 0.108 |
253827 | MSRB3 | P24T-E | Human | Esophagus | ESCC | 1.13e-07 | 2.34e-01 | 0.1287 |
253827 | MSRB3 | P26T-E | Human | Esophagus | ESCC | 1.37e-32 | 6.12e-01 | 0.1276 |
253827 | MSRB3 | P27T-E | Human | Esophagus | ESCC | 4.03e-04 | 1.16e-01 | 0.1055 |
253827 | MSRB3 | P30T-E | Human | Esophagus | ESCC | 2.38e-02 | 1.95e-01 | 0.137 |
253827 | MSRB3 | P32T-E | Human | Esophagus | ESCC | 1.32e-32 | 6.27e-01 | 0.1666 |
253827 | MSRB3 | P36T-E | Human | Esophagus | ESCC | 3.38e-08 | 1.87e-01 | 0.1187 |
253827 | MSRB3 | P37T-E | Human | Esophagus | ESCC | 6.69e-21 | 5.13e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:000697922 | Liver | HCC | response to oxidative stress | 281/7958 | 446/18723 | 9.75e-19 | 1.24e-16 | 281 |
GO:000697918 | Prostate | BPH | response to oxidative stress | 142/3107 | 446/18723 | 8.11e-16 | 1.36e-13 | 142 |
GO:000697934 | Thyroid | ATC | response to oxidative stress | 246/6293 | 446/18723 | 2.98e-21 | 6.09e-19 | 246 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MSRB3 | SNV | Missense_Mutation | novel | c.466N>G | p.Arg156Gly | p.R156G | Q8IXL7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MSRB3 | SNV | Missense_Mutation | rs568898551 | c.157C>T | p.Arg53Trp | p.R53W | Q8IXL7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-6678-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
MSRB3 | SNV | Missense_Mutation | c.211T>A | p.Phe71Ile | p.F71I | Q8IXL7 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AG-3883-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MSRB3 | SNV | Missense_Mutation | c.229C>G | p.His77Asp | p.H77D | Q8IXL7 | protein_coding | tolerated(0.74) | benign(0.003) | TCGA-EI-6884-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5 | SD | |
MSRB3 | insertion | Frame_Shift_Ins | novel | c.569_570insA | p.Glu191GlyfsTer5 | p.E191Gfs*5 | Q8IXL7 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MSRB3 | insertion | Frame_Shift_Ins | novel | c.570_571insGCTTT | p.Glu191AlafsTer29 | p.E191Afs*29 | Q8IXL7 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MSRB3 | SNV | Missense_Mutation | novel | c.179A>G | p.His60Arg | p.H60R | Q8IXL7 | protein_coding | tolerated(0.18) | benign(0.037) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MSRB3 | SNV | Missense_Mutation | rs370812570 | c.101C>T | p.Ser34Leu | p.S34L | Q8IXL7 | protein_coding | deleterious(0) | benign(0.407) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MSRB3 | SNV | Missense_Mutation | rs776973896 | c.202G>A | p.Glu68Lys | p.E68K | Q8IXL7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MSRB3 | SNV | Missense_Mutation | rs199788089 | c.569N>T | p.Ala190Val | p.A190V | Q8IXL7 | protein_coding | deleterious_low_confidence(0.01) | benign(0.017) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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