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Gene: MRM2 |
Gene summary for MRM2 |
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Gene information | Species | Human | Gene symbol | MRM2 | Gene ID | 29960 |
Gene name | mitochondrial rRNA methyltransferase 2 | |
Gene Alias | FJH1 | |
Cytomap | 7p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000154 | UniProtAcc | Q9UI43 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29960 | MRM2 | HCC2 | Human | Liver | HCC | 1.12e-11 | 3.46e+00 | 0.5341 |
29960 | MRM2 | S014 | Human | Liver | HCC | 3.19e-29 | 8.00e-01 | 0.2254 |
29960 | MRM2 | S015 | Human | Liver | HCC | 9.10e-29 | 8.63e-01 | 0.2375 |
29960 | MRM2 | S016 | Human | Liver | HCC | 1.64e-36 | 9.00e-01 | 0.2243 |
29960 | MRM2 | S027 | Human | Liver | HCC | 2.79e-08 | 5.25e-01 | 0.2446 |
29960 | MRM2 | S028 | Human | Liver | HCC | 1.20e-28 | 8.07e-01 | 0.2503 |
29960 | MRM2 | S029 | Human | Liver | HCC | 2.19e-23 | 6.89e-01 | 0.2581 |
29960 | MRM2 | PTC01 | Human | Thyroid | PTC | 7.91e-06 | 1.06e-01 | 0.1899 |
29960 | MRM2 | PTC05 | Human | Thyroid | PTC | 2.73e-08 | 2.36e-01 | 0.2065 |
29960 | MRM2 | PTC06 | Human | Thyroid | PTC | 5.12e-18 | 2.83e-01 | 0.2057 |
29960 | MRM2 | PTC07 | Human | Thyroid | PTC | 6.64e-16 | 2.73e-01 | 0.2044 |
29960 | MRM2 | ATC12 | Human | Thyroid | ATC | 2.10e-13 | 2.45e-01 | 0.34 |
29960 | MRM2 | ATC13 | Human | Thyroid | ATC | 1.06e-16 | 3.62e-01 | 0.34 |
29960 | MRM2 | ATC2 | Human | Thyroid | ATC | 2.25e-14 | 8.38e-01 | 0.34 |
29960 | MRM2 | ATC4 | Human | Thyroid | ATC | 1.31e-18 | 3.61e-01 | 0.34 |
29960 | MRM2 | ATC5 | Human | Thyroid | ATC | 2.39e-21 | 4.06e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0001510 | Liver | HCC | RNA methylation | 53/7958 | 83/18723 | 6.96e-05 | 6.29e-04 | 53 |
GO:0022613113 | Thyroid | PTC | ribonucleoprotein complex biogenesis | 292/5968 | 463/18723 | 3.24e-44 | 2.05e-40 | 292 |
GO:0042254113 | Thyroid | PTC | ribosome biogenesis | 202/5968 | 299/18723 | 3.47e-37 | 5.47e-34 | 202 |
GO:0006364112 | Thyroid | PTC | rRNA processing | 156/5968 | 225/18723 | 5.58e-31 | 5.03e-28 | 156 |
GO:0016072112 | Thyroid | PTC | rRNA metabolic process | 160/5968 | 236/18723 | 5.68e-30 | 3.58e-27 | 160 |
GO:003447018 | Thyroid | PTC | ncRNA processing | 215/5968 | 395/18723 | 7.14e-21 | 1.22e-18 | 215 |
GO:00346608 | Thyroid | PTC | ncRNA metabolic process | 239/5968 | 485/18723 | 5.54e-16 | 4.26e-14 | 239 |
GO:00322594 | Thyroid | PTC | methylation | 146/5968 | 364/18723 | 4.99e-04 | 3.26e-03 | 146 |
GO:00434145 | Thyroid | PTC | macromolecule methylation | 127/5968 | 316/18723 | 1.02e-03 | 6.07e-03 | 127 |
GO:002261334 | Thyroid | ATC | ribonucleoprotein complex biogenesis | 292/6293 | 463/18723 | 3.05e-39 | 9.63e-36 | 292 |
GO:004225434 | Thyroid | ATC | ribosome biogenesis | 203/6293 | 299/18723 | 3.63e-34 | 4.59e-31 | 203 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRM2 | SNV | Missense_Mutation | c.411G>C | p.Gln137His | p.Q137H | Q9UI43 | protein_coding | deleterious(0.03) | possibly_damaging(0.516) | TCGA-97-A4M0-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MRM2 | SNV | Missense_Mutation | c.328G>A | p.Gly110Arg | p.G110R | Q9UI43 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MRM2 | SNV | Missense_Mutation | c.5N>T | p.Ala2Val | p.A2V | Q9UI43 | protein_coding | deleterious_low_confidence(0.01) | benign(0.059) | TCGA-22-5473-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
MRM2 | SNV | Missense_Mutation | novel | c.239N>T | p.Gly80Val | p.G80V | Q9UI43 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-43-8116-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MRM2 | SNV | Missense_Mutation | novel | c.707N>T | p.Gln236Leu | p.Q236L | Q9UI43 | protein_coding | tolerated(0.36) | benign(0.006) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD |
MRM2 | SNV | Missense_Mutation | novel | c.340C>G | p.Leu114Val | p.L114V | Q9UI43 | protein_coding | deleterious(0.01) | probably_damaging(0.95) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
MRM2 | SNV | Missense_Mutation | c.596G>A | p.Ser199Asn | p.S199N | Q9UI43 | protein_coding | tolerated(0.41) | benign(0.006) | TCGA-BR-8289-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
MRM2 | SNV | Missense_Mutation | c.668N>A | p.Ser223Asn | p.S223N | Q9UI43 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | |
MRM2 | SNV | Missense_Mutation | rs759079801 | c.299N>G | p.Asp100Gly | p.D100G | Q9UI43 | protein_coding | deleterious(0.03) | benign(0.116) | TCGA-BR-8486-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRM2 | SNV | Missense_Mutation | rs138187457 | c.67N>T | p.Arg23Cys | p.R23C | Q9UI43 | protein_coding | tolerated(0.28) | benign(0.001) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
29960 | MRM2 | NA | Plazomicin | PLAZOMICIN |
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