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Gene: MRGPRF |
Gene summary for MRGPRF |
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Gene information | Species | Human | Gene symbol | MRGPRF | Gene ID | 116535 |
Gene name | MAS related GPR family member F | |
Gene Alias | GPR140 | |
Cytomap | 11q13.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A0A024R5F0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116535 | MRGPRF | S014 | Human | Liver | HCC | 4.71e-09 | 5.79e-01 | 0.2254 |
116535 | MRGPRF | S015 | Human | Liver | HCC | 1.78e-23 | 1.06e+00 | 0.2375 |
116535 | MRGPRF | S016 | Human | Liver | HCC | 3.70e-26 | 9.30e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRGPRF | SNV | Missense_Mutation | novel | c.41N>T | p.Arg14Met | p.R14M | Q96AM1 | protein_coding | deleterious_low_confidence(0.01) | benign(0.094) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
MRGPRF | SNV | Missense_Mutation | c.337G>A | p.Asp113Asn | p.D113N | Q96AM1 | protein_coding | tolerated(0.46) | benign(0.142) | TCGA-D1-A17B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRGPRF | SNV | Missense_Mutation | novel | c.719N>C | p.Val240Ala | p.V240A | Q96AM1 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
MRGPRF | SNV | Missense_Mutation | rs755456887 | c.944N>A | p.Arg315Gln | p.R315Q | Q96AM1 | protein_coding | tolerated(0.4) | probably_damaging(0.988) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MRGPRF | SNV | Missense_Mutation | c.691N>T | p.Arg231Cys | p.R231C | Q96AM1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-86-8054-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | CR | |
MRGPRF | SNV | Missense_Mutation | c.28C>T | p.His10Tyr | p.H10Y | Q96AM1 | protein_coding | tolerated_low_confidence(0.09) | benign(0.069) | TCGA-MP-A4TK-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MRGPRF | SNV | Missense_Mutation | novel | c.22N>A | p.Glu8Lys | p.E8K | Q96AM1 | protein_coding | deleterious_low_confidence(0.02) | benign(0.023) | TCGA-33-4589-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRGPRF | SNV | Missense_Mutation | c.313G>T | p.Gly105Trp | p.G105W | Q96AM1 | protein_coding | tolerated(0.09) | probably_damaging(0.998) | TCGA-37-4141-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRGPRF | deletion | Frame_Shift_Del | c.33delN | p.Gly12AlafsTer10 | p.G12Afs*10 | Q96AM1 | protein_coding | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |||
MRGPRF | SNV | Missense_Mutation | rs143408398 | c.34G>A | p.Gly12Ser | p.G12S | Q96AM1 | protein_coding | tolerated_low_confidence(0.73) | benign(0) | TCGA-CV-5978-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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