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Gene: MOB3A |
Gene summary for MOB3A |
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Gene information | Species | Human | Gene symbol | MOB3A | Gene ID | 126308 |
Gene name | MOB kinase activator 3A | |
Gene Alias | MOB-LAK | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q96BX8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126308 | MOB3A | LZE4T | Human | Esophagus | ESCC | 1.87e-07 | 2.13e-01 | 0.0811 |
126308 | MOB3A | LZE7T | Human | Esophagus | ESCC | 3.68e-02 | 9.16e-02 | 0.0667 |
126308 | MOB3A | LZE8T | Human | Esophagus | ESCC | 4.04e-07 | 1.53e-01 | 0.067 |
126308 | MOB3A | LZE20T | Human | Esophagus | ESCC | 1.22e-02 | 6.00e-02 | 0.0662 |
126308 | MOB3A | LZE24T | Human | Esophagus | ESCC | 9.92e-14 | 1.58e-01 | 0.0596 |
126308 | MOB3A | LZE6T | Human | Esophagus | ESCC | 5.39e-11 | 4.69e-01 | 0.0845 |
126308 | MOB3A | P1T-E | Human | Esophagus | ESCC | 4.78e-03 | 1.75e-01 | 0.0875 |
126308 | MOB3A | P2T-E | Human | Esophagus | ESCC | 5.27e-12 | 2.03e-01 | 0.1177 |
126308 | MOB3A | P4T-E | Human | Esophagus | ESCC | 3.10e-23 | 3.45e-01 | 0.1323 |
126308 | MOB3A | P5T-E | Human | Esophagus | ESCC | 5.26e-06 | 4.91e-02 | 0.1327 |
126308 | MOB3A | P8T-E | Human | Esophagus | ESCC | 1.84e-03 | 5.14e-02 | 0.0889 |
126308 | MOB3A | P9T-E | Human | Esophagus | ESCC | 1.90e-10 | 2.12e-01 | 0.1131 |
126308 | MOB3A | P10T-E | Human | Esophagus | ESCC | 1.87e-12 | 1.83e-01 | 0.116 |
126308 | MOB3A | P11T-E | Human | Esophagus | ESCC | 2.96e-17 | 3.28e-01 | 0.1426 |
126308 | MOB3A | P12T-E | Human | Esophagus | ESCC | 5.54e-12 | 2.61e-01 | 0.1122 |
126308 | MOB3A | P15T-E | Human | Esophagus | ESCC | 4.95e-16 | 3.28e-01 | 0.1149 |
126308 | MOB3A | P16T-E | Human | Esophagus | ESCC | 2.15e-07 | 9.19e-02 | 0.1153 |
126308 | MOB3A | P17T-E | Human | Esophagus | ESCC | 4.03e-15 | 4.35e-01 | 0.1278 |
126308 | MOB3A | P19T-E | Human | Esophagus | ESCC | 7.11e-07 | 4.43e-01 | 0.1662 |
126308 | MOB3A | P20T-E | Human | Esophagus | ESCC | 2.75e-16 | 2.54e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MOB3A | SNV | Missense_Mutation | rs772988384 | c.298N>T | p.Arg100Cys | p.R100C | Q96BX8 | protein_coding | tolerated(0.16) | probably_damaging(0.93) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MOB3A | SNV | Missense_Mutation | rs772099363 | c.244G>A | p.Gly82Ser | p.G82S | Q96BX8 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MOB3A | SNV | Missense_Mutation | novel | c.470C>T | p.Ser157Leu | p.S157L | Q96BX8 | protein_coding | deleterious(0.01) | benign(0.244) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MOB3A | SNV | Missense_Mutation | novel | c.121G>A | p.Ala41Thr | p.A41T | Q96BX8 | protein_coding | deleterious(0.04) | benign(0.212) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MOB3A | SNV | Missense_Mutation | rs772988384 | c.298C>T | p.Arg100Cys | p.R100C | Q96BX8 | protein_coding | tolerated(0.16) | probably_damaging(0.93) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
MOB3A | SNV | Missense_Mutation | rs200952352 | c.322N>T | p.Arg108Trp | p.R108W | Q96BX8 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MOB3A | SNV | Missense_Mutation | rs201880293 | c.163G>A | p.Glu55Lys | p.E55K | Q96BX8 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
MOB3A | SNV | Missense_Mutation | rs142028177 | c.637G>A | p.Ala213Thr | p.A213T | Q96BX8 | protein_coding | tolerated(0.13) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MOB3A | SNV | Missense_Mutation | novel | c.403C>A | p.Leu135Ile | p.L135I | Q96BX8 | protein_coding | tolerated(1) | benign(0.005) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
MOB3A | SNV | Missense_Mutation | rs142102227 | c.523N>A | p.Ala175Thr | p.A175T | Q96BX8 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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