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Gene: MFSD6 |
Gene summary for MFSD6 |
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Gene information | Species | Human | Gene symbol | MFSD6 | Gene ID | 54842 |
Gene name | major facilitator superfamily domain containing 6 | |
Gene Alias | MMR2 | |
Cytomap | 2q32.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q6ZSS7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54842 | MFSD6 | LZE4T | Human | Esophagus | ESCC | 2.46e-03 | 6.50e-02 | 0.0811 |
54842 | MFSD6 | LZE24T | Human | Esophagus | ESCC | 1.31e-10 | 1.05e-01 | 0.0596 |
54842 | MFSD6 | P2T-E | Human | Esophagus | ESCC | 2.21e-11 | 5.16e-02 | 0.1177 |
54842 | MFSD6 | P4T-E | Human | Esophagus | ESCC | 6.82e-12 | 2.32e-01 | 0.1323 |
54842 | MFSD6 | P5T-E | Human | Esophagus | ESCC | 1.33e-10 | 1.92e-02 | 0.1327 |
54842 | MFSD6 | P8T-E | Human | Esophagus | ESCC | 6.03e-14 | 1.31e-01 | 0.0889 |
54842 | MFSD6 | P9T-E | Human | Esophagus | ESCC | 4.44e-09 | 2.19e-01 | 0.1131 |
54842 | MFSD6 | P10T-E | Human | Esophagus | ESCC | 5.09e-11 | 1.83e-01 | 0.116 |
54842 | MFSD6 | P11T-E | Human | Esophagus | ESCC | 3.45e-05 | 8.51e-02 | 0.1426 |
54842 | MFSD6 | P12T-E | Human | Esophagus | ESCC | 2.01e-17 | 2.05e-01 | 0.1122 |
54842 | MFSD6 | P15T-E | Human | Esophagus | ESCC | 1.64e-17 | 2.88e-01 | 0.1149 |
54842 | MFSD6 | P16T-E | Human | Esophagus | ESCC | 3.75e-07 | 3.46e-02 | 0.1153 |
54842 | MFSD6 | P17T-E | Human | Esophagus | ESCC | 2.47e-02 | 1.46e-01 | 0.1278 |
54842 | MFSD6 | P20T-E | Human | Esophagus | ESCC | 8.09e-18 | 2.93e-01 | 0.1124 |
54842 | MFSD6 | P21T-E | Human | Esophagus | ESCC | 5.27e-18 | 4.03e-01 | 0.1617 |
54842 | MFSD6 | P22T-E | Human | Esophagus | ESCC | 3.77e-09 | 1.26e-01 | 0.1236 |
54842 | MFSD6 | P23T-E | Human | Esophagus | ESCC | 9.42e-40 | 1.12e+00 | 0.108 |
54842 | MFSD6 | P24T-E | Human | Esophagus | ESCC | 2.10e-11 | 1.16e-01 | 0.1287 |
54842 | MFSD6 | P26T-E | Human | Esophagus | ESCC | 2.19e-06 | 9.37e-02 | 0.1276 |
54842 | MFSD6 | P27T-E | Human | Esophagus | ESCC | 6.06e-10 | 6.30e-02 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004800220 | Esophagus | ESCC | antigen processing and presentation of peptide antigen | 44/8552 | 62/18723 | 4.81e-05 | 3.78e-04 | 44 |
GO:000247820 | Esophagus | ESCC | antigen processing and presentation of exogenous peptide antigen | 29/8552 | 38/18723 | 1.18e-04 | 8.13e-04 | 29 |
GO:001988225 | Esophagus | ESCC | antigen processing and presentation | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
GO:000247418 | Esophagus | ESCC | antigen processing and presentation of peptide antigen via MHC class I | 22/8552 | 28/18723 | 3.95e-04 | 2.26e-03 | 22 |
GO:001988420 | Esophagus | ESCC | antigen processing and presentation of exogenous antigen | 33/8552 | 47/18723 | 5.77e-04 | 3.14e-03 | 33 |
GO:001988220 | Oral cavity | OSCC | antigen processing and presentation | 65/7305 | 106/18723 | 2.69e-06 | 3.32e-05 | 65 |
GO:004800219 | Oral cavity | OSCC | antigen processing and presentation of peptide antigen | 40/7305 | 62/18723 | 4.20e-05 | 3.63e-04 | 40 |
GO:000247416 | Oral cavity | OSCC | antigen processing and presentation of peptide antigen via MHC class I | 21/7305 | 28/18723 | 1.19e-04 | 8.54e-04 | 21 |
GO:000247819 | Oral cavity | OSCC | antigen processing and presentation of exogenous peptide antigen | 26/7305 | 38/18723 | 2.29e-04 | 1.49e-03 | 26 |
GO:001988419 | Oral cavity | OSCC | antigen processing and presentation of exogenous antigen | 30/7305 | 47/18723 | 4.96e-04 | 2.92e-03 | 30 |
GO:0019882110 | Oral cavity | LP | antigen processing and presentation | 48/4623 | 106/18723 | 2.96e-06 | 6.44e-05 | 48 |
GO:0048002110 | Oral cavity | LP | antigen processing and presentation of peptide antigen | 30/4623 | 62/18723 | 4.46e-05 | 6.35e-04 | 30 |
GO:0002478110 | Oral cavity | LP | antigen processing and presentation of exogenous peptide antigen | 20/4623 | 38/18723 | 1.95e-04 | 2.15e-03 | 20 |
GO:000247417 | Oral cavity | LP | antigen processing and presentation of peptide antigen via MHC class I | 16/4623 | 28/18723 | 2.46e-04 | 2.60e-03 | 16 |
GO:0019884110 | Oral cavity | LP | antigen processing and presentation of exogenous antigen | 22/4623 | 47/18723 | 8.02e-04 | 7.05e-03 | 22 |
GO:0019882112 | Thyroid | PTC | antigen processing and presentation | 57/5968 | 106/18723 | 2.40e-06 | 3.17e-05 | 57 |
GO:0002478112 | Thyroid | PTC | antigen processing and presentation of exogenous peptide antigen | 25/5968 | 38/18723 | 1.80e-05 | 1.86e-04 | 25 |
GO:0048002112 | Thyroid | PTC | antigen processing and presentation of peptide antigen | 36/5968 | 62/18723 | 1.84e-05 | 1.89e-04 | 36 |
GO:0019884112 | Thyroid | PTC | antigen processing and presentation of exogenous antigen | 29/5968 | 47/18723 | 2.44e-05 | 2.40e-04 | 29 |
GO:0002474110 | Thyroid | PTC | antigen processing and presentation of peptide antigen via MHC class I | 19/5968 | 28/18723 | 9.95e-05 | 8.15e-04 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MFSD6 | SNV | Missense_Mutation | novel | c.1294N>C | p.Ala432Pro | p.A432P | Q6ZSS7 | protein_coding | tolerated(0.31) | benign(0.082) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MFSD6 | deletion | Frame_Shift_Del | c.1497delT | p.Phe499LeufsTer8 | p.F499Lfs*8 | Q6ZSS7 | protein_coding | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
MFSD6 | deletion | Frame_Shift_Del | c.1497delT | p.Phe499LeufsTer8 | p.F499Lfs*8 | Q6ZSS7 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
MFSD6 | deletion | Frame_Shift_Del | c.1507_1526delNNNNNNNNNNNNNNNNNNNN | p.Leu503HisfsTer56 | p.L503Hfs*56 | Q6ZSS7 | protein_coding | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |||
MFSD6 | insertion | Frame_Shift_Ins | novel | c.508_509insAAAGGGGG | p.Thr170LysfsTer10 | p.T170Kfs*10 | Q6ZSS7 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MFSD6 | SNV | Missense_Mutation | novel | c.1768N>A | p.Gly590Arg | p.G590R | Q6ZSS7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MFSD6 | SNV | Missense_Mutation | rs779381360 | c.380N>A | p.Arg127His | p.R127H | Q6ZSS7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MFSD6 | SNV | Missense_Mutation | c.586N>T | p.Arg196Cys | p.R196C | Q6ZSS7 | protein_coding | deleterious(0.01) | possibly_damaging(0.614) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MFSD6 | SNV | Missense_Mutation | novel | c.1604N>T | p.Thr535Ile | p.T535I | Q6ZSS7 | protein_coding | tolerated(0.57) | benign(0.058) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MFSD6 | SNV | Missense_Mutation | rs371311716 | c.1066N>A | p.Asp356Asn | p.D356N | Q6ZSS7 | protein_coding | tolerated(0.34) | benign(0.023) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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