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Gene: METTL10 |
Gene summary for METTL10 |
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Gene information | Species | Human | Gene symbol | METTL10 | Gene ID | 399818 |
Gene name | EEF1A lysine methyltransferase 2 | |
Gene Alias | C10orf138 | |
Cytomap | 10q26.13 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q5JPI9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
399818 | METTL10 | P1T-E | Human | Esophagus | ESCC | 1.01e-02 | 1.58e-01 | 0.0875 |
399818 | METTL10 | P2T-E | Human | Esophagus | ESCC | 8.18e-34 | 6.11e-01 | 0.1177 |
399818 | METTL10 | P4T-E | Human | Esophagus | ESCC | 3.53e-21 | 5.31e-01 | 0.1323 |
399818 | METTL10 | P5T-E | Human | Esophagus | ESCC | 9.90e-37 | 7.11e-01 | 0.1327 |
399818 | METTL10 | P8T-E | Human | Esophagus | ESCC | 9.25e-17 | 1.98e-01 | 0.0889 |
399818 | METTL10 | P9T-E | Human | Esophagus | ESCC | 3.42e-10 | 1.12e-01 | 0.1131 |
399818 | METTL10 | P10T-E | Human | Esophagus | ESCC | 5.18e-14 | 2.20e-01 | 0.116 |
399818 | METTL10 | P11T-E | Human | Esophagus | ESCC | 1.64e-14 | 3.57e-01 | 0.1426 |
399818 | METTL10 | P12T-E | Human | Esophagus | ESCC | 4.60e-17 | 4.30e-01 | 0.1122 |
399818 | METTL10 | P15T-E | Human | Esophagus | ESCC | 1.28e-08 | 1.90e-01 | 0.1149 |
399818 | METTL10 | P16T-E | Human | Esophagus | ESCC | 2.33e-26 | 5.18e-01 | 0.1153 |
399818 | METTL10 | P17T-E | Human | Esophagus | ESCC | 3.20e-08 | 3.18e-01 | 0.1278 |
399818 | METTL10 | P19T-E | Human | Esophagus | ESCC | 2.28e-05 | 4.89e-01 | 0.1662 |
399818 | METTL10 | P20T-E | Human | Esophagus | ESCC | 9.24e-14 | 2.02e-01 | 0.1124 |
399818 | METTL10 | P21T-E | Human | Esophagus | ESCC | 1.08e-18 | 3.00e-01 | 0.1617 |
399818 | METTL10 | P22T-E | Human | Esophagus | ESCC | 2.40e-11 | 1.50e-01 | 0.1236 |
399818 | METTL10 | P23T-E | Human | Esophagus | ESCC | 1.30e-20 | 4.14e-01 | 0.108 |
399818 | METTL10 | P24T-E | Human | Esophagus | ESCC | 1.03e-22 | 5.31e-01 | 0.1287 |
399818 | METTL10 | P26T-E | Human | Esophagus | ESCC | 1.15e-27 | 5.34e-01 | 0.1276 |
399818 | METTL10 | P27T-E | Human | Esophagus | ESCC | 1.35e-17 | 4.15e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
METTL10 | SNV | Missense_Mutation | c.863N>T | p.Ser288Leu | p.S288L | Q5JPI9 | protein_coding | tolerated_low_confidence(0.25) | benign(0) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
METTL10 | SNV | Missense_Mutation | rs780294019 | c.479N>A | p.Ser160Asn | p.S160N | Q5JPI9 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
METTL10 | SNV | Missense_Mutation | c.216G>A | p.Met72Ile | p.M72I | Q5JPI9 | protein_coding | tolerated(0.72) | benign(0.007) | TCGA-35-4122-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
METTL10 | SNV | Missense_Mutation | c.253N>C | p.Asp85His | p.D85H | Q5JPI9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-A4DF-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
METTL10 | SNV | Missense_Mutation | novel | c.607N>A | p.Phe203Ile | p.F203I | Q5JPI9 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-85-8351-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
METTL10 | SNV | Missense_Mutation | rs765714970 | c.341N>T | p.Ala114Val | p.A114V | Q5JPI9 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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