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Gene: MEPCE |
Gene summary for MEPCE |
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Gene information | Species | Human | Gene symbol | MEPCE | Gene ID | 56257 |
Gene name | methylphosphate capping enzyme | |
Gene Alias | BCDIN3 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q7L2J0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56257 | MEPCE | LZE4T | Human | Esophagus | ESCC | 7.05e-03 | -2.72e-02 | 0.0811 |
56257 | MEPCE | LZE7T | Human | Esophagus | ESCC | 7.17e-04 | 1.53e-01 | 0.0667 |
56257 | MEPCE | LZE20T | Human | Esophagus | ESCC | 5.33e-09 | 1.23e-01 | 0.0662 |
56257 | MEPCE | LZE24T | Human | Esophagus | ESCC | 7.77e-10 | 3.14e-01 | 0.0596 |
56257 | MEPCE | P1T-E | Human | Esophagus | ESCC | 4.12e-12 | 6.41e-01 | 0.0875 |
56257 | MEPCE | P2T-E | Human | Esophagus | ESCC | 2.21e-31 | 4.89e-01 | 0.1177 |
56257 | MEPCE | P4T-E | Human | Esophagus | ESCC | 5.17e-12 | 5.50e-02 | 0.1323 |
56257 | MEPCE | P5T-E | Human | Esophagus | ESCC | 4.89e-10 | -4.11e-02 | 0.1327 |
56257 | MEPCE | P8T-E | Human | Esophagus | ESCC | 1.14e-15 | 7.37e-02 | 0.0889 |
56257 | MEPCE | P9T-E | Human | Esophagus | ESCC | 3.06e-14 | 1.72e-01 | 0.1131 |
56257 | MEPCE | P10T-E | Human | Esophagus | ESCC | 6.18e-16 | 1.94e-01 | 0.116 |
56257 | MEPCE | P11T-E | Human | Esophagus | ESCC | 1.25e-05 | 3.18e-01 | 0.1426 |
56257 | MEPCE | P12T-E | Human | Esophagus | ESCC | 1.55e-16 | 2.02e-01 | 0.1122 |
56257 | MEPCE | P15T-E | Human | Esophagus | ESCC | 2.27e-16 | 2.08e-01 | 0.1149 |
56257 | MEPCE | P16T-E | Human | Esophagus | ESCC | 2.97e-14 | 1.64e-01 | 0.1153 |
56257 | MEPCE | P17T-E | Human | Esophagus | ESCC | 1.20e-06 | 3.21e-01 | 0.1278 |
56257 | MEPCE | P20T-E | Human | Esophagus | ESCC | 2.60e-12 | 1.82e-01 | 0.1124 |
56257 | MEPCE | P21T-E | Human | Esophagus | ESCC | 2.22e-17 | 7.79e-02 | 0.1617 |
56257 | MEPCE | P22T-E | Human | Esophagus | ESCC | 5.63e-12 | -3.29e-02 | 0.1236 |
56257 | MEPCE | P23T-E | Human | Esophagus | ESCC | 4.02e-13 | 4.01e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:1903829111 | Esophagus | ESCC | positive regulation of cellular protein localization | 199/8552 | 276/18723 | 2.99e-19 | 3.45e-17 | 199 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:190018018 | Esophagus | ESCC | regulation of protein localization to nucleus | 102/8552 | 136/18723 | 2.84e-12 | 1.13e-10 | 102 |
GO:190018217 | Esophagus | ESCC | positive regulation of protein localization to nucleus | 70/8552 | 87/18723 | 2.63e-11 | 8.99e-10 | 70 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:0051100111 | Esophagus | ESCC | negative regulation of binding | 109/8552 | 162/18723 | 2.10e-08 | 4.03e-07 | 109 |
GO:00987812 | Esophagus | ESCC | ncRNA transcription | 45/8552 | 56/18723 | 1.05e-07 | 1.72e-06 | 45 |
GO:004593116 | Esophagus | ESCC | positive regulation of mitotic cell cycle | 83/8552 | 121/18723 | 2.78e-07 | 4.08e-06 | 83 |
GO:000008214 | Esophagus | ESCC | G1/S transition of mitotic cell cycle | 134/8552 | 214/18723 | 4.04e-07 | 5.55e-06 | 134 |
GO:004484314 | Esophagus | ESCC | cell cycle G1/S phase transition | 148/8552 | 241/18723 | 5.68e-07 | 7.48e-06 | 148 |
GO:19019896 | Esophagus | ESCC | positive regulation of cell cycle phase transition | 77/8552 | 115/18723 | 3.20e-06 | 3.58e-05 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MEPCE | SNV | Missense_Mutation | c.607N>A | p.Glu203Lys | p.E203K | Q7L2J0 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MEPCE | SNV | Missense_Mutation | rs760815358 | c.1184N>G | p.His395Arg | p.H395R | Q7L2J0 | protein_coding | tolerated(0.6) | benign(0.011) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MEPCE | SNV | Missense_Mutation | novel | c.1792C>T | p.Arg598Cys | p.R598C | Q7L2J0 | protein_coding | deleterious(0.03) | benign(0.29) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MEPCE | SNV | Missense_Mutation | c.1693N>A | p.Asp565Asn | p.D565N | Q7L2J0 | protein_coding | deleterious(0) | possibly_damaging(0.563) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MEPCE | SNV | Missense_Mutation | c.1486N>T | p.Arg496Cys | p.R496C | Q7L2J0 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MEPCE | SNV | Missense_Mutation | c.1097N>A | p.Arg366His | p.R366H | Q7L2J0 | protein_coding | deleterious(0.01) | benign(0.168) | TCGA-D5-6931-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MEPCE | SNV | Missense_Mutation | c.1926N>T | p.Leu642Phe | p.L642F | Q7L2J0 | protein_coding | tolerated(0.18) | probably_damaging(0.99) | TCGA-D5-6931-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MEPCE | SNV | Missense_Mutation | rs745881376 | c.551A>C | p.Asn184Thr | p.N184T | Q7L2J0 | protein_coding | tolerated(0.08) | possibly_damaging(0.868) | TCGA-NH-A50U-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | PD |
MEPCE | SNV | Missense_Mutation | c.1553G>A | p.Arg518Gln | p.R518Q | Q7L2J0 | protein_coding | tolerated(0.25) | benign(0.024) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MEPCE | SNV | Missense_Mutation | c.1877G>T | p.Arg626Ile | p.R626I | Q7L2J0 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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